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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:MFS40622_1271
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002189 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987391 – 2272-phospho-L-lactate guanylyltransferaseAdd BLAST227

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi644281.MFS40622_1271.

Structurei

3D structure databases

ProteinModelPortaliD3S534.
SMRiD3S534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiFRVDYHG.
OrthoDBiPOG093Z0CT7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

D3S534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLIPVSPI NSLKTRLSEF LSSEERKNLL LNMLRDINKA LEGLDVVIIS
60 70 80 90 100
RDEEILEFGK NELKAETIKE KYKGLNKAIK QAFEEIEDDE VIIIPADIPL
110 120 130 140 150
IKKRHIEDIL KLSKDYDVII APSRGGGTNL LYLKSKNLIE IKYEGFSFLK
160 170 180 190 200
HLEEAKKKNL RYYIYDSFLI SVDINTPEDL GEIFIHGDST YTKNYLKGLG
210 220
IEVESKHSSA GRFVVKRGGD NEVSNPM
Length:227
Mass (Da):25,888
Last modified:April 20, 2010 - v1
Checksum:iE53D1B281964CF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA. Translation: ADC69948.1.
RefSeqiWP_012980856.1. NC_013887.1.

Genome annotation databases

EnsemblBacteriaiADC69948; ADC69948; MFS40622_1271.
GeneIDi8805130.
KEGGimfs:MFS40622_1271.

Similar proteinsi

Entry informationi

Entry nameiCOFC_METSF
AccessioniPrimary (citable) accession number: D3S534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 20, 2010
Last modified: December 20, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families