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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP644281:G1GHG-1291-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:MFS40622_1271
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002189 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987391 – 2272-phospho-L-lactate guanylyltransferaseAdd BLAST227

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi644281.MFS40622_1271

Structurei

3D structure databases

ProteinModelPortaliD3S534
SMRiD3S534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472 Archaea
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

D3S534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLIPVSPI NSLKTRLSEF LSSEERKNLL LNMLRDINKA LEGLDVVIIS
60 70 80 90 100
RDEEILEFGK NELKAETIKE KYKGLNKAIK QAFEEIEDDE VIIIPADIPL
110 120 130 140 150
IKKRHIEDIL KLSKDYDVII APSRGGGTNL LYLKSKNLIE IKYEGFSFLK
160 170 180 190 200
HLEEAKKKNL RYYIYDSFLI SVDINTPEDL GEIFIHGDST YTKNYLKGLG
210 220
IEVESKHSSA GRFVVKRGGD NEVSNPM
Length:227
Mass (Da):25,888
Last modified:April 20, 2010 - v1
Checksum:iE53D1B281964CF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA Translation: ADC69948.1
RefSeqiWP_012980856.1, NC_013887.1

Genome annotation databases

EnsemblBacteriaiADC69948; ADC69948; MFS40622_1271
GeneIDi8805130
KEGGimfs:MFS40622_1271

Similar proteinsi

Entry informationi

Entry nameiCOFC_METSF
AccessioniPrimary (citable) accession number: D3S534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 20, 2010
Last modified: February 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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