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Protein

DNA ligase

Gene

lig

Organism
Ferroglobus placidus (strain DSM 10642 / AEDII12DO)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei338ATPUniRule annotation1
Binding sitei412ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFPLA589924:G1GHF-28-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ferp_0025Imported
OrganismiFerroglobus placidus (strain DSM 10642 / AEDII12DO)Imported
Taxonomic identifieri589924 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeFerroglobus
Proteomesi
  • UP000002613 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi589924.Ferp_0025

Structurei

3D structure databases

ProteinModelPortaliD3S0Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 453DNA_LIGASE_A3InterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili228 – 248Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D3S0Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFKEFAEF CSVIEKISST LELTARIAAF IRKIEDEDDL YNVIHFLMGR
60 70 80 90 100
IFPPWDEREI GVGVGLIYEA LRQVTGVSKS RIEQLVKETG DLGLAAERLL
110 120 130 140 150
KEKKQTTLFQ EELTIKRVKE IFEEMAKLSG EGSQKRRVML LTDLYVSATP
160 170 180 190 200
IETRYLTRLI LGEMRLGVGE GIIRDAIARA FGIDSSIVER AYMLTNDYGR
210 220 230 240 250
VAVVAKKEGK DGLMRMKIQL HYPVKMMLAQ VAESVDEALR EMREAAVEWK
260 270 280 290 300
YDGSRVQVHY GNGKVTIFSR RLENVTSALP EIVDEVKKCV RENVILDGEV
310 320 330 340 350
IAVKDGKPMP FQQVLRRFRR KHEISKAMER IPLIVYFFDI LYDGEMLIDL
360 370 380 390 400
PLKERRKKLE EVIGESEIIK VAQQVITSDP KVVEEEFNRA IEAGHEGLML
410 420 430 440 450
KRLDSPYTPG KRGKLWLKLK AVMETLDLVV VGGEWGEGKR SHLLSSFELA
460 470 480 490 500
CRDENGRLLR VGKVATGFTD EDLEELTELF KPLIEYEEGK RVVFQPKYLF
510 520 530 540 550
EVAYQEIQKS PKYESGFALR FPRFVRLRDD KSVEEADTLE RIAKLYEMQF

KSKGG
Length:555
Mass (Da):63,726
Last modified:April 20, 2010 - v1
Checksum:i4479C2BC547A3420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001899 Genomic DNA Translation: ADC64217.1
RefSeqiWP_012964566.1, NC_013849.1

Genome annotation databases

EnsemblBacteriaiADC64217; ADC64217; Ferp_0025
GeneIDi8777517
KEGGifpl:Ferp_0025

Similar proteinsi

Entry informationi

Entry nameiD3S0Y1_FERPA
AccessioniPrimary (citable) accession number: D3S0Y1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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