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D3S0Y1

- D3S0Y1_FERPA

UniProt

D3S0Y1 - D3S0Y1_FERPA

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Protein
DNA ligase
Gene
lig, Ferp_0025
Organism
Ferroglobus placidus (strain DSM 10642 / AEDII12DO)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarityUniRule annotation
Active sitei250 – 2501N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei255 – 2551ATP By similarityUniRule annotation
Binding sitei270 – 2701ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei338 – 3381ATP By similarityUniRule annotation
Binding sitei412 – 4121ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFPLA589924:GHX0-27-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ferp_0025Imported
OrganismiFerroglobus placidus (strain DSM 10642 / AEDII12DO)Imported
Taxonomic identifieri589924 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeFerroglobus
ProteomesiUP000002613: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3S0Y1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S0Y1-1 [UniParc]FASTAAdd to Basket

« Hide

MLTFKEFAEF CSVIEKISST LELTARIAAF IRKIEDEDDL YNVIHFLMGR    50
IFPPWDEREI GVGVGLIYEA LRQVTGVSKS RIEQLVKETG DLGLAAERLL 100
KEKKQTTLFQ EELTIKRVKE IFEEMAKLSG EGSQKRRVML LTDLYVSATP 150
IETRYLTRLI LGEMRLGVGE GIIRDAIARA FGIDSSIVER AYMLTNDYGR 200
VAVVAKKEGK DGLMRMKIQL HYPVKMMLAQ VAESVDEALR EMREAAVEWK 250
YDGSRVQVHY GNGKVTIFSR RLENVTSALP EIVDEVKKCV RENVILDGEV 300
IAVKDGKPMP FQQVLRRFRR KHEISKAMER IPLIVYFFDI LYDGEMLIDL 350
PLKERRKKLE EVIGESEIIK VAQQVITSDP KVVEEEFNRA IEAGHEGLML 400
KRLDSPYTPG KRGKLWLKLK AVMETLDLVV VGGEWGEGKR SHLLSSFELA 450
CRDENGRLLR VGKVATGFTD EDLEELTELF KPLIEYEEGK RVVFQPKYLF 500
EVAYQEIQKS PKYESGFALR FPRFVRLRDD KSVEEADTLE RIAKLYEMQF 550
KSKGG 555
Length:555
Mass (Da):63,726
Last modified:April 20, 2010 - v1
Checksum:i4479C2BC547A3420
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001899 Genomic DNA. Translation: ADC64217.1.
RefSeqiYP_003434492.1. NC_013849.1.

Genome annotation databases

EnsemblBacteriaiADC64217; ADC64217; Ferp_0025.
GeneIDi8777517.
KEGGifpl:Ferp_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001899 Genomic DNA. Translation: ADC64217.1 .
RefSeqi YP_003434492.1. NC_013849.1.

3D structure databases

ProteinModelPortali D3S0Y1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC64217 ; ADC64217 ; Ferp_0025 .
GeneIDi 8777517.
KEGGi fpl:Ferp_0025.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci FPLA589924:GHX0-27-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10642 / AEDII12DO.

Entry informationi

Entry nameiD3S0Y1_FERPA
AccessioniPrimary (citable) accession number: D3S0Y1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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