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D3S0Y1

- D3S0Y1_FERPA

UniProt

D3S0Y1 - D3S0Y1_FERPA

Protein

DNA ligase

Gene

lig

Organism
Ferroglobus placidus (strain DSM 10642 / AEDII12DO)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPUniRule annotation
    Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
    Binding sitei255 – 2551ATPUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei338 – 3381ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFPLA589924:GHX0-27-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Ferp_0025Imported
    OrganismiFerroglobus placidus (strain DSM 10642 / AEDII12DO)Imported
    Taxonomic identifieri589924 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeFerroglobus
    ProteomesiUP000002613: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD3S0Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3S0Y1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTFKEFAEF CSVIEKISST LELTARIAAF IRKIEDEDDL YNVIHFLMGR    50
    IFPPWDEREI GVGVGLIYEA LRQVTGVSKS RIEQLVKETG DLGLAAERLL 100
    KEKKQTTLFQ EELTIKRVKE IFEEMAKLSG EGSQKRRVML LTDLYVSATP 150
    IETRYLTRLI LGEMRLGVGE GIIRDAIARA FGIDSSIVER AYMLTNDYGR 200
    VAVVAKKEGK DGLMRMKIQL HYPVKMMLAQ VAESVDEALR EMREAAVEWK 250
    YDGSRVQVHY GNGKVTIFSR RLENVTSALP EIVDEVKKCV RENVILDGEV 300
    IAVKDGKPMP FQQVLRRFRR KHEISKAMER IPLIVYFFDI LYDGEMLIDL 350
    PLKERRKKLE EVIGESEIIK VAQQVITSDP KVVEEEFNRA IEAGHEGLML 400
    KRLDSPYTPG KRGKLWLKLK AVMETLDLVV VGGEWGEGKR SHLLSSFELA 450
    CRDENGRLLR VGKVATGFTD EDLEELTELF KPLIEYEEGK RVVFQPKYLF 500
    EVAYQEIQKS PKYESGFALR FPRFVRLRDD KSVEEADTLE RIAKLYEMQF 550
    KSKGG 555
    Length:555
    Mass (Da):63,726
    Last modified:April 20, 2010 - v1
    Checksum:i4479C2BC547A3420
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001899 Genomic DNA. Translation: ADC64217.1.
    RefSeqiYP_003434492.1. NC_013849.1.

    Genome annotation databases

    EnsemblBacteriaiADC64217; ADC64217; Ferp_0025.
    GeneIDi8777517.
    KEGGifpl:Ferp_0025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001899 Genomic DNA. Translation: ADC64217.1 .
    RefSeqi YP_003434492.1. NC_013849.1.

    3D structure databases

    ProteinModelPortali D3S0Y1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC64217 ; ADC64217 ; Ferp_0025 .
    GeneIDi 8777517.
    KEGGi fpl:Ferp_0025.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci FPLA589924:GHX0-27-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10642 / AEDII12DOImported.

    Entry informationi

    Entry nameiD3S0Y1_FERPA
    AccessioniPrimary (citable) accession number: D3S0Y1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3