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D3S0Y1 (D3S0Y1_FERPA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Ferp_0025 EMBL ADC64217.1
OrganismFerroglobus placidus (strain DSM 10642 / AEDII12DO) [Complete proteome] [HAMAP] EMBL ADC64217.1
Taxonomic identifier589924 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeFerroglobus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2501N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2481ATP By similarity HAMAP-Rule MF_00407
Binding site2551ATP By similarity HAMAP-Rule MF_00407
Binding site2701ATP By similarity HAMAP-Rule MF_00407
Binding site2991ATP By similarity HAMAP-Rule MF_00407
Binding site3381ATP By similarity HAMAP-Rule MF_00407
Binding site4121ATP By similarity HAMAP-Rule MF_00407
Binding site4181ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D3S0Y1 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 4479C2BC547A3420

FASTA55563,726
        10         20         30         40         50         60 
MLTFKEFAEF CSVIEKISST LELTARIAAF IRKIEDEDDL YNVIHFLMGR IFPPWDEREI 

        70         80         90        100        110        120 
GVGVGLIYEA LRQVTGVSKS RIEQLVKETG DLGLAAERLL KEKKQTTLFQ EELTIKRVKE 

       130        140        150        160        170        180 
IFEEMAKLSG EGSQKRRVML LTDLYVSATP IETRYLTRLI LGEMRLGVGE GIIRDAIARA 

       190        200        210        220        230        240 
FGIDSSIVER AYMLTNDYGR VAVVAKKEGK DGLMRMKIQL HYPVKMMLAQ VAESVDEALR 

       250        260        270        280        290        300 
EMREAAVEWK YDGSRVQVHY GNGKVTIFSR RLENVTSALP EIVDEVKKCV RENVILDGEV 

       310        320        330        340        350        360 
IAVKDGKPMP FQQVLRRFRR KHEISKAMER IPLIVYFFDI LYDGEMLIDL PLKERRKKLE 

       370        380        390        400        410        420 
EVIGESEIIK VAQQVITSDP KVVEEEFNRA IEAGHEGLML KRLDSPYTPG KRGKLWLKLK 

       430        440        450        460        470        480 
AVMETLDLVV VGGEWGEGKR SHLLSSFELA CRDENGRLLR VGKVATGFTD EDLEELTELF 

       490        500        510        520        530        540 
KPLIEYEEGK RVVFQPKYLF EVAYQEIQKS PKYESGFALR FPRFVRLRDD KSVEEADTLE 

       550 
RIAKLYEMQF KSKGG 

« Hide

References

[1]"Complete sequence of Ferroglobus placidus DSM 10642."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Holmes D. expand/collapse author list , Lovley D., Kyrpides N., Anderson I.J., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10642 / AEDII12DO.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001899 Genomic DNA. Translation: ADC64217.1.
RefSeqYP_003434492.1. NC_013849.1.

3D structure databases

ProteinModelPortalD3S0Y1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC64217; ADC64217; Ferp_0025.
GeneID8777517.
KEGGfpl:Ferp_0025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.
OMAARVQVHK.

Enzyme and pathway databases

BioCycFPLA589924:GHX0-27-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3S0Y1_FERPA
AccessionPrimary (citable) accession number: D3S0Y1
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)