D3RYU7 (D3RYU7_FERPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
EC=6.3.5.3 HAMAP-Rule MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420

Gene names

Name:	purL HAMAP-Rule MF_00420
Ordered Locus Names:	Ferp_1509

Organism

Ferroglobus placidus (strain DSM 10642 / AEDII12DO) [Complete proteome] [HAMAP] EMBL ADC65660.1

Taxonomic identifier

589924 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Ferroglobus › Ferroglobus placidus

Protein attributes

Sequence length	755 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP-Rule MF_00420
Cellular component	Cytoplasm HAMAP-Rule MF_00420
Ligand	ATP-binding HAMAP-Rule MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_00420 EMBL ADC65660.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	125 – 136	12	ATP By similarity HAMAP-Rule MF_00420

Sequences

	Sequence		Length	Mass (Da)
	D3RYU7 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 23D93EE2DB2C41A2	FASTA	755	83,949
	10 20 30 40 50 60 MYREIYPGVY EVDILNASDE DLVKISEEMG LNLSLDEMKV IKEYFKKKGR NPRDIELQAL 70 80 90 100 110 120 GQAWSEHCCY KSSKYWLKKY LLGFKTDYVI STEYDAGVVE FDEEQAYVVA LESHNHPSAV 130 140 150 160 170 180 EPYGGAATGI GGILRDVLCM GAQPVALVDP LFFGELSTPY EKLPPGIKHP VYLLEGVVAG 190 200 210 220 230 240 IRDYGNRVGI PTVAGMVFFD ESYLTNCLVN VGCVGIAKKD RIIPSKAGGE GDIFILAGGA 250 260 270 280 290 300 TGRDGIHGVT FASAELTDTE STRSAVQLGN PIMKEPLIHA CLEIVEKGLL TGMKDLGGGG 310 320 330 340 350 360 LSCAVGEMAL AAGYGAEVWL DKVHLKEKDM KPWEIWISES QERMLLTVKP KHVDEVLYIF 370 380 390 400 410 420 RKWDVPASVI GVVKGEKVLR VYYKDWLIYE MDIEFVTKGP EYCRATAEKR EKVEVDEVKE 430 440 450 460 470 480 PEDFAKVFLK MMSHPNVASK EWVIRQYDHE VRGNTVLKPL QGRIGFETHG DAAVVKPTES 490 500 510 520 530 540 WRGLAITADV NPWMTRIDPF WGTASAFDEM VRNLVAVNSR PHSFVDCLNF GNPEKPERMW 550 560 570 580 590 600 EFVESVKALG WMSKEFGLPC VSGNVSFYNE TPYGGVAPTP TLMGIGIVED VRKAVTSNFK 610 620 630 640 650 660 KEGSEIVLVG ETKREFGGSL YSKVTGMKCN VVPKTDPKVL KNYAEAMLEA FKKFKVLSCH 670 680 690 700 710 720 DPAEGGVAVA LAEMAICGIG FEVDLSFTEL FSESNTRWIV EVKNAENFVN FFEEKGLRAR 730 740 750 VIGYTGGDKL NYGRFSVELS EVEKAWRSGF SKFLR

References

[1]

"Complete sequence of Ferroglobus placidus DSM 10642." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Holmes D. , Lovley D., Kyrpides N., Anderson I.J., Woyke T. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 10642 / AEDII12DO.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001899 Genomic DNA. Translation: ADC65660.1.
RefSeq	YP_003435935.1. NC_013849.1.
3D structure databases
ProteinModelPortal	D3RYU7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADC65660; ADC65660; Ferp_1509.
GeneID	8779029.
KEGG	fpl:Ferp_1509.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000238227.
KO	K01952.
OMA	WSEHCCY.
Enzyme and pathway databases
BioCyc	FPLA589924:GHX0-1540-MONOMER.
UniPathway	UPA00074; UER00128.
Family and domain databases
HAMAP	MF_00420. PurL_2.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D3RYU7_FERPA

Accession

Primary (citable) accession number: D3RYU7

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)