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D3RX66

- PSB_FERPA

UniProt

D3RX66 - PSB_FERPA

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Protein

Proteasome subunit beta

Gene

psmB

Organism
Ferroglobus placidus (strain DSM 10642 / AEDII12DO)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101NucleophileUniRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciFPLA589924:GHX0-931-MONOMER.

Protein family/group databases

MEROPSiT01.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PsmBUniRule annotation
Gene namesi
Name:psmBUniRule annotation
Ordered Locus Names:Ferp_0913
OrganismiFerroglobus placidus (strain DSM 10642 / AEDII12DO)
Taxonomic identifieri589924 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeFerroglobus
ProteomesiUP000002613: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99Removed in mature form; by autocatalysisUniRule annotationPRO_0000397292
Chaini10 – 210201Proteasome subunit betaPRO_0000397293Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000091083.
KOiK03433.
OMAiMVDWLGT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A.
InterProiIPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03634. arc_protsome_B. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3RX66-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIHDKVFKGT TTVGLVCKDG VVLATEKRAT MGNFIASRRA KKIYKITDRI
60 70 80 90 100
AMTTAGSVGD AQFLARLIKV ETNLYTIRKE EEPTVKAVAT LVSNLLNSVR
110 120 130 140 150
YFPYLVQLLI GGVDKTGAKI YSIDPIGGAI EEIDIVATGS GSPMAYGVLE
160 170 180 190 200
DNYRKDINVD EAVELAIRAI YSAMKRDSAS GDGIDVVKIT EKEYVELTPE
210
EIEAILEKLR
Length:210
Mass (Da):22,979
Last modified:April 20, 2010 - v1
Checksum:i181CADCFC13C6EF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001899 Genomic DNA. Translation: ADC65079.1.
RefSeqiYP_003435354.1. NC_013849.1.

Genome annotation databases

EnsemblBacteriaiADC65079; ADC65079; Ferp_0913.
GeneIDi8778421.
KEGGifpl:Ferp_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001899 Genomic DNA. Translation: ADC65079.1 .
RefSeqi YP_003435354.1. NC_013849.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC65079 ; ADC65079 ; Ferp_0913 .
GeneIDi 8778421.
KEGGi fpl:Ferp_0913.

Phylogenomic databases

HOGENOMi HOG000091083.
KOi K03433.
OMAi MVDWLGT.

Enzyme and pathway databases

BioCyci FPLA589924:GHX0-931-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_A. Proteasome_B_A.
InterProi IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03634. arc_protsome_B. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10642 / AEDII12DO.

Entry informationi

Entry nameiPSB_FERPA
AccessioniPrimary (citable) accession number: D3RX66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3