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D3RPJ5 (D3RPJ5_ALLVD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase HAMAP-Rule MF_01659
Short name=SEPHCHC synthase HAMAP-Rule MF_01659
EC=2.2.1.9 HAMAP-Rule MF_01659
Alternative name(s):
Menaquinone biosynthesis protein MenD HAMAP-Rule MF_01659
Gene names
Name:menD HAMAP-Rule MF_01659
Ordered Locus Names:Alvin_0627 EMBL ADC61577.1
OrganismAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum) [Complete proteome] [HAMAP] EMBL ADC61577.1
Taxonomic identifier572477 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Allochromatium ›

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Catalytic activity

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2. HAMAP-Rule MF_01659 SAAS SAAS012001

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Magnesium or manganese By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 2/8. HAMAP-Rule MF_01659 SAAS SAAS012001

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Sequence similarities

Belongs to the TPP enzyme family. MenD subfamily. HAMAP-Rule MF_01659

Sequences

Sequence LengthMass (Da)Tools
D3RPJ5 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 84E25481A55AD1B6

FASTA58663,534
        10         20         30         40         50         60 
MTDQGCLNLR WALALFDGLV EGGMRHLVLS PGSRSTPLVL AAQRQPALTV TPILDERSAA 

        70         80         90        100        110        120 
FFALGVARAS GRPVGLVCTS GSALAHWFPA VIEASESGIP LVLLSADRPP ELRGWGANQT 

       130        140        150        160        170        180 
IDQTRFFGVH VRAFHDPGTP EDSPGAVKLM RALGRRAAVE SQGDWPGPVH LNLPFREPLV 

       190        200        210        220        230        240 
PGPDCRIEAA PIQTESAVSD TMGTRRPARP AGWGLPQTPP RSDWMSARIS HGSGRGVICC 

       250        260        270        280        290        300 
GPGDWTADGA EALWHLAMRL EVPVLCDPLS GLRFGCASEH RLTRYDSLLR HPATAAALKP 

       310        320        330        340        350        360 
DWVLRFGRAP VSKTLLGWLA DVPTILVDAG RGWSDPNHDV RLKIDADPAA FCVWLADADP 

       370        380        390        400        410        420 
EPGTPDPDWF ARWLQAERRL ERFAAEYLDQ APWCEGHLIR DLIAQVPEGE GLLCANSMPI 

       430        440        450        460        470        480 
RQLDTWSGSR VRPLRVFGHR GASGIDGQTS TLAGLNAGGL PTTGLLGDLS FLHDLSGLPA 

       490        500        510        520        530        540 
LRTLSRPCIV INNGGGRIFD YLPQHGLPGF ETLWRTPVAV DLRALAGTFG LAHRSVSDRD 

       550        560        570        580 
GFRQALTESM QTDRPSGLIE VVIDADLSRQ IHRDFWRAVS VRRDDA

« Hide

References

[1]"Complete sequence of chromosome of Allochromatium vinosum DSM 180."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001896 Genomic DNA. Translation: ADC61577.1.
RefSeqYP_003442609.1. NC_013851.1.

3D structure databases

ProteinModelPortalD3RPJ5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC61577; ADC61577; Alvin_0627.
GeneID8785965.
KEGGalv:Alvin_0627.
PATRIC31921009. VBIAllVin64954_0627.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000218359.
KOK02551.

Enzyme and pathway databases

UniPathwayUPA00079; UER00164.

Family and domain databases

HAMAPMF_01659. MenD.
InterProIPR004433. MenaQ_synth_MenD.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view]
PANTHERPTHR18968:SF3. PTHR18968:SF3. 1 hit.
PfamPF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFPIRSF004983. MenD. 1 hit.
TIGRFAMsTIGR00173. menD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3RPJ5_ALLVD
AccessionPrimary (citable) accession number: D3RPJ5
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info