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D3R4D8

- D3R4D8_BIFAB

UniProt

D3R4D8 - D3R4D8_BIFAB

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Protein

Alanine racemase

Gene

BIF_02122

Organism
Bifidobacterium animalis subsp. lactis (strain BB-12)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Active sitei327 – 3271Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei391 – 3911Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBANI552531:GL90-1151-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:BIF_02122Imported
OrganismiBifidobacterium animalis subsp. lactis (strain BB-12)Imported
Taxonomic identifieri552531 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002042: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3R4D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3R4D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCESTSHAY PLTHSSYEQA TMVCMSVSAL EEWQFSSEQG ERNYNQALRE
60 70 80 90 100
YPAQVIVDLA ALRDNMRHLV DITNREGGPT EVMGVVKADA YGHGLVPSAL
110 120 130 140 150
AALAGGATWL GVAQAREALA LRNAGIGVDR ARVLTWVNNP LHAPYDDLIA
160 170 180 190 200
ADVDLSVATL TAIQKIAEAA RAVGKPARVH IKVDTGFGRN GFTLAQIDSA
210 220 230 240 250
IDLLLPLVDE GVFEIVGQWS HLAVADAPAV GEFVEKTDEQ IRVFEEFTSR
260 270 280 290 300
LHARGIEPRI RHLANTAATL SRPEIHYDLV RPGVALYGYE ADPAMGTPSK
310 320 330 340 350
YELRPAMTLQ AQLSSVKNVG AGEGLSYGRV YVTDEPTSAA IVPVGYADGI
360 370 380 390 400
HRSASGFNEA GSKHVNKPGA PVRVMTRDGA RIFHVSGRVC MDQFILDLHG
410 420 430 440 450
DAENMGVHIG DTVELFGPGR GEDYLEPTAD DWARAADTIS YEIFTCLRNR
460 470
VPRLYANAFE VLDETDLGKL DQSTLL
Length:476
Mass (Da):51,535
Last modified:April 20, 2010 - v1
Checksum:iE0D46D6F4D371430
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1.
RefSeqiYP_005576622.1. NC_017214.1.

Genome annotation databases

EnsemblBacteriaiADC85612; ADC85612; BIF_02122.
GeneIDi12176195.
KEGGibbb:BIF_02122.
PATRICi36803068. VBIBifAni31632_1077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1 .
RefSeqi YP_005576622.1. NC_017214.1.

3D structure databases

ProteinModelPortali D3R4D8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC85612 ; ADC85612 ; BIF_02122 .
GeneIDi 12176195.
KEGGi bbb:BIF_02122.
PATRICi 36803068. VBIBifAni31632_1077.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BANI552531:GL90-1151-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Bifidobacterium animalis subsp. lactis BB-12, a widely consumed probiotic strain."
    Garrigues C., Johansen E., Pedersen M.B.
    J. Bacteriol. 192:2467-2468(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BB-12Imported.

Entry informationi

Entry nameiD3R4D8_BIFAB
AccessioniPrimary (citable) accession number: D3R4D8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3