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D3R4D8

- D3R4D8_BIFAB

UniProt

D3R4D8 - D3R4D8_BIFAB

Protein

Alanine racemase

Gene

BIF_02122

Organism
Bifidobacterium animalis subsp. lactis (strain BB-12)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei189 – 1891SubstrateUniRule annotation
    Active sitei327 – 3271Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei391 – 3911Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBANI552531:GL90-1151-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:BIF_02122Imported
    OrganismiBifidobacterium animalis subsp. lactis (strain BB-12)Imported
    Taxonomic identifieri552531 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002042: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei87 – 871N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3R4D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3R4D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCESTSHAY PLTHSSYEQA TMVCMSVSAL EEWQFSSEQG ERNYNQALRE    50
    YPAQVIVDLA ALRDNMRHLV DITNREGGPT EVMGVVKADA YGHGLVPSAL 100
    AALAGGATWL GVAQAREALA LRNAGIGVDR ARVLTWVNNP LHAPYDDLIA 150
    ADVDLSVATL TAIQKIAEAA RAVGKPARVH IKVDTGFGRN GFTLAQIDSA 200
    IDLLLPLVDE GVFEIVGQWS HLAVADAPAV GEFVEKTDEQ IRVFEEFTSR 250
    LHARGIEPRI RHLANTAATL SRPEIHYDLV RPGVALYGYE ADPAMGTPSK 300
    YELRPAMTLQ AQLSSVKNVG AGEGLSYGRV YVTDEPTSAA IVPVGYADGI 350
    HRSASGFNEA GSKHVNKPGA PVRVMTRDGA RIFHVSGRVC MDQFILDLHG 400
    DAENMGVHIG DTVELFGPGR GEDYLEPTAD DWARAADTIS YEIFTCLRNR 450
    VPRLYANAFE VLDETDLGKL DQSTLL 476
    Length:476
    Mass (Da):51,535
    Last modified:April 20, 2010 - v1
    Checksum:iE0D46D6F4D371430
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001853 Genomic DNA. Translation: ADC85612.1.
    RefSeqiYP_005576622.1. NC_017214.1.

    Genome annotation databases

    EnsemblBacteriaiADC85612; ADC85612; BIF_02122.
    GeneIDi12176195.
    KEGGibbb:BIF_02122.
    PATRICi36803068. VBIBifAni31632_1077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001853 Genomic DNA. Translation: ADC85612.1 .
    RefSeqi YP_005576622.1. NC_017214.1.

    3D structure databases

    ProteinModelPortali D3R4D8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC85612 ; ADC85612 ; BIF_02122 .
    GeneIDi 12176195.
    KEGGi bbb:BIF_02122.
    PATRICi 36803068. VBIBifAni31632_1077.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci BANI552531:GL90-1151-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bifidobacterium animalis subsp. lactis BB-12, a widely consumed probiotic strain."
      Garrigues C., Johansen E., Pedersen M.B.
      J. Bacteriol. 192:2467-2468(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BB-12Imported.

    Entry informationi

    Entry nameiD3R4D8_BIFAB
    AccessioniPrimary (citable) accession number: D3R4D8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3