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Protein

Alanine racemase

Gene

BIF_02122

Organism
Bifidobacterium animalis subsp. lactis (strain BB-12)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Active sitei327 – 3271Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei391 – 3911Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBANI552531:GL90-1151-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:BIF_02122Imported
OrganismiBifidobacterium animalis subsp. lactis (strain BB-12)Imported
Taxonomic identifieri552531 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002042: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3R4D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3R4D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCESTSHAY PLTHSSYEQA TMVCMSVSAL EEWQFSSEQG ERNYNQALRE
60 70 80 90 100
YPAQVIVDLA ALRDNMRHLV DITNREGGPT EVMGVVKADA YGHGLVPSAL
110 120 130 140 150
AALAGGATWL GVAQAREALA LRNAGIGVDR ARVLTWVNNP LHAPYDDLIA
160 170 180 190 200
ADVDLSVATL TAIQKIAEAA RAVGKPARVH IKVDTGFGRN GFTLAQIDSA
210 220 230 240 250
IDLLLPLVDE GVFEIVGQWS HLAVADAPAV GEFVEKTDEQ IRVFEEFTSR
260 270 280 290 300
LHARGIEPRI RHLANTAATL SRPEIHYDLV RPGVALYGYE ADPAMGTPSK
310 320 330 340 350
YELRPAMTLQ AQLSSVKNVG AGEGLSYGRV YVTDEPTSAA IVPVGYADGI
360 370 380 390 400
HRSASGFNEA GSKHVNKPGA PVRVMTRDGA RIFHVSGRVC MDQFILDLHG
410 420 430 440 450
DAENMGVHIG DTVELFGPGR GEDYLEPTAD DWARAADTIS YEIFTCLRNR
460 470
VPRLYANAFE VLDETDLGKL DQSTLL
Length:476
Mass (Da):51,535
Last modified:April 20, 2010 - v1
Checksum:iE0D46D6F4D371430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1.
RefSeqiYP_005576622.1. NC_017214.1.

Genome annotation databases

EnsemblBacteriaiADC85612; ADC85612; BIF_02122.
GeneIDi12176195.
KEGGibbb:BIF_02122.
PATRICi36803068. VBIBifAni31632_1077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1.
RefSeqiYP_005576622.1. NC_017214.1.

3D structure databases

ProteinModelPortaliD3R4D8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC85612; ADC85612; BIF_02122.
GeneIDi12176195.
KEGGibbb:BIF_02122.
PATRICi36803068. VBIBifAni31632_1077.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBANI552531:GL90-1151-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Bifidobacterium animalis subsp. lactis BB-12, a widely consumed probiotic strain."
    Garrigues C., Johansen E., Pedersen M.B.
    J. Bacteriol. 192:2467-2468(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BB-12Imported.

Entry informationi

Entry nameiD3R4D8_BIFAB
AccessioniPrimary (citable) accession number: D3R4D8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.