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D3R4D8

- D3R4D8_BIFAB

UniProt

D3R4D8 - D3R4D8_BIFAB

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Protein
Alanine racemase
Gene
BIF_02122
Organism
Bifidobacterium animalis subsp. lactis (strain BB-12)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei189 – 1891Substrate By similarityUniRule annotation
Active sitei327 – 3271Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei391 – 3911Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBANI552531:GL90-1151-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:BIF_02122Imported
OrganismiBifidobacterium animalis subsp. lactis (strain BB-12)Imported
Taxonomic identifieri552531 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002042: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3R4D8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3R4D8-1 [UniParc]FASTAAdd to Basket

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MGCESTSHAY PLTHSSYEQA TMVCMSVSAL EEWQFSSEQG ERNYNQALRE    50
YPAQVIVDLA ALRDNMRHLV DITNREGGPT EVMGVVKADA YGHGLVPSAL 100
AALAGGATWL GVAQAREALA LRNAGIGVDR ARVLTWVNNP LHAPYDDLIA 150
ADVDLSVATL TAIQKIAEAA RAVGKPARVH IKVDTGFGRN GFTLAQIDSA 200
IDLLLPLVDE GVFEIVGQWS HLAVADAPAV GEFVEKTDEQ IRVFEEFTSR 250
LHARGIEPRI RHLANTAATL SRPEIHYDLV RPGVALYGYE ADPAMGTPSK 300
YELRPAMTLQ AQLSSVKNVG AGEGLSYGRV YVTDEPTSAA IVPVGYADGI 350
HRSASGFNEA GSKHVNKPGA PVRVMTRDGA RIFHVSGRVC MDQFILDLHG 400
DAENMGVHIG DTVELFGPGR GEDYLEPTAD DWARAADTIS YEIFTCLRNR 450
VPRLYANAFE VLDETDLGKL DQSTLL 476
Length:476
Mass (Da):51,535
Last modified:April 20, 2010 - v1
Checksum:iE0D46D6F4D371430
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1.
RefSeqiYP_005576622.1. NC_017214.1.

Genome annotation databases

EnsemblBacteriaiADC85612; ADC85612; BIF_02122.
GeneIDi12176195.
KEGGibbb:BIF_02122.
PATRICi36803068. VBIBifAni31632_1077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001853 Genomic DNA. Translation: ADC85612.1 .
RefSeqi YP_005576622.1. NC_017214.1.

3D structure databases

ProteinModelPortali D3R4D8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC85612 ; ADC85612 ; BIF_02122 .
GeneIDi 12176195.
KEGGi bbb:BIF_02122.
PATRICi 36803068. VBIBifAni31632_1077.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BANI552531:GL90-1151-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Bifidobacterium animalis subsp. lactis BB-12, a widely consumed probiotic strain."
    Garrigues C., Johansen E., Pedersen M.B.
    J. Bacteriol. 192:2467-2468(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BB-12Imported.

Entry informationi

Entry nameiD3R4D8_BIFAB
AccessioniPrimary (citable) accession number: D3R4D8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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