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Protein

Transaldolase

Gene

talA

Organism
Escherichia coli O55:H7 (strain CB9615 / EPEC)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.UniRule annotationSAAS annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.UniRule annotationSAAS annotation

Pathway:ipentose phosphate pathway

This protein is involved in step 2 and 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (talB), Transaldolase (talB), Transaldolase (talA), Transaldolase (talA)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Pathway:ipentose phosphate pathway

This protein is involved in step 2 and 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (talB), Transaldolase (talB), Transaldolase (talA), Transaldolase (talA)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Schiff-base intermediate with substrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Pentose shuntUniRule annotation

Keywords - Ligandi

Schiff baseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciECOL701177:GI1N-2987-MONOMER.
UniPathwayiUPA00115; UER00414.
UPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
TransaldolaseUniRule annotation (EC:2.2.1.2UniRule annotation)
Gene namesi
Name:talAImported
Synonyms:talUniRule annotation
Ordered Locus Names:G2583_2986Imported
OrganismiEscherichia coli O55:H7 (strain CB9615 / EPEC)Imported
Taxonomic identifieri701177 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001521 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiD3QM42.

Interactioni

Subunit structurei

Homodimer.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3QM42.
SMRiD3QM42. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000281234.
KOiK00616.
OMAiIRLFAID.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3QM42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELDGIKQF TTVVADSGDI ESIRHYHPQD ATTNPSLLLK AAGLSQYEHL
60 70 80 90 100
IDDAIAWGKK NGKTQEQQVV AACDKLAVNF GAEILKIVPG RVSTEVDARL
110 120 130 140 150
SFDKEKSIEK ARHLVDLYQQ QGVEKSRILI KLASTWEGIR AAEELEKEGI
160 170 180 190 200
NCNLTLLFSF AQARACAEAG VFLISPFVGR IYDWYQARKP MDPYVVEEDP
210 220 230 240 250
GVKSVRNIYD YYKQHHYETI VMGASFRRTE QILALTGCDR LTIAPNLLKE
260 270 280 290 300
LQEKVSPVVR KLIPPSQTFP RPAPMSEAEF RWEHNQDAMA VEKLSEGIRL
310
FAVDQRKLED LLAAKL
Length:316
Mass (Da):35,659
Last modified:April 20, 2010 - v1
Checksum:i990B00ED7937CF19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001846 Genomic DNA. Translation: ADD57517.1.
RefSeqiWP_001003709.1. NC_013941.1.

Genome annotation databases

EnsemblBacteriaiADD57517; ADD57517; G2583_2986.
KEGGieok:G2583_2986.
PATRICi35345102. VBIEscCol154499_3017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001846 Genomic DNA. Translation: ADD57517.1.
RefSeqiWP_001003709.1. NC_013941.1.

3D structure databases

ProteinModelPortaliD3QM42.
SMRiD3QM42. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3QM42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADD57517; ADD57517; G2583_2986.
KEGGieok:G2583_2986.
PATRICi35345102. VBIEscCol154499_3017.

Phylogenomic databases

HOGENOMiHOG000281234.
KOiK00616.
OMAiIRLFAID.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
UPA00115; UER00414.
BioCyciECOL701177:GI1N-2987-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Derivation of Escherichia coli O157:H7 from its O55:H7 precursor."
    Zhou Z., Li X., Liu B., Beutin L., Xu J., Ren Y., Feng L., Lan R., Reeves P.R., Wang L.
    PLoS ONE 5:E8700-E8700(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CB9615 / EPECImported.

Entry informationi

Entry nameiD3QM42_ECOCB
AccessioniPrimary (citable) accession number: D3QM42
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.