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Protein

Alanine racemase

Gene

SLGD_00946

Organism
Staphylococcus lugdunensis (strain HKU09-01)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei265 – 2651Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSLUG698737:GHG4-945-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:SLGD_00946Imported
OrganismiStaphylococcus lugdunensis (strain HKU09-01)Imported
Taxonomic identifieri698737 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002041 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3QIM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiSVELWGD.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3QIM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKYYRNTY INVDLAAINN NYRQFTQLHD NKTVIPVIKA NGYGLGSVRI
60 70 80 90 100
AQYLVDHGAS FFAVATLDEA IELRMHGIKA QILILGVIPI EDINKAIQHR
110 120 130 140 150
VAITVPSKSW LSSAIKAIND DNEKRLWLHI KLDTGMGRLG IKNQAEYHQT
160 170 180 190 200
IHLIEQHEHL VFEGVYTHFA CADEPGDSAQ QQYQCFKTWV TSTDMPRYVH
210 220 230 240 250
AQNSAGALMI DADICNAVRL GISLYGYYPS EYVKEEADIE LQPSAELMTQ
260 270 280 290 300
IVQTKELQPG ESVSYGSTYT AQSPIKIGII PIGYADGYLR IMQGHFVNVK
310 320 330 340 350
GQQCEVIGRV CMDQTIIKIN DDILEGDEVC VISKQQDSIQ SVDAIAKQQK
360 370 380
TINYEVLCNL GRRLPRIYKF DNKEYIINDL LK
Length:382
Mass (Da):43,106
Last modified:April 20, 2010 - v1
Checksum:i89F3BF757B662D47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001837 Genomic DNA. Translation: ADC87084.1.
RefSeqiYP_003471211.1. NC_013893.1.

Genome annotation databases

EnsemblBacteriaiADC87084; ADC87084; SLGD_00946.
KEGGislg:SLGD_00946.
PATRICi35305252. VBIStaLug155172_0930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001837 Genomic DNA. Translation: ADC87084.1.
RefSeqiYP_003471211.1. NC_013893.1.

3D structure databases

ProteinModelPortaliD3QIM1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC87084; ADC87084; SLGD_00946.
KEGGislg:SLGD_00946.
PATRICi35305252. VBIStaLug155172_0930.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiSVELWGD.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSLUG698737:GHG4-945-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Staphylococcus lugdunensis strain HKU09-01."
    Tse H., Tsoi H.W., Leung S.P., Lau S.K., Woo P.C., Yuen K.Y.
    J. Bacteriol. 192:1471-1472(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKU09-01Imported.

Entry informationi

Entry nameiD3QIM1_STALH
AccessioniPrimary (citable) accession number: D3QIM1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 29, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.