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Protein

Alanine racemase

Gene

SLGD_01492

Organism
Staphylococcus lugdunensis (strain HKU09-01)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSLUG698737:GHG4-1489-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:SLGD_01492Imported
OrganismiStaphylococcus lugdunensis (strain HKU09-01)Imported
Taxonomic identifieri698737 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002041: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3QCY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280025.
KOiK01775.
OMAiVHLEYEN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.

Sequencei

Sequence statusi: Complete.

D3QCY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATWSVNSD IFFNNVVTVK NNQPIMAVVK NNAYHYGLEY AVNMFLKAGI
60 70 80 90 100
NTFSTTSLKE AVRIRKLAPK ATIFLMNAVY DFDIVRHNRI HMTLPSLQYY
110 120 130 140 150
YANKSNLYDI NVHLEYENLL HRSGFKNLSE LREVLKDHEQ NNQPHKMHIT
160 170 180 190 200
GLWTHFGYAD EFDVPEYDTE KRAWLKVLNT LLAEGYTFDM IHAQNSASFY
210 220 230 240 250
REQHQVLSNH THARVGIALY GSRPYSSLKP SEIKQALTVK ANVIQVREVN
260 270 280 290 300
KGDYCGYSFA YECKNHHTRL AVVDIGYGDG ILKSRAQHDV IINGKRYPIR
310 320 330 340 350
ALMMSHMFVE VDELVHARDE VVLYNNDIRI DEFTFKGVGA NSEQLSAMNH

DSLIKEYK
Length:358
Mass (Da):41,337
Last modified:April 20, 2010 - v1
Checksum:i3FFEB75E478AB135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001837 Genomic DNA. Translation: ADC87583.1.
RefSeqiYP_003471710.1. NC_013893.1.

Genome annotation databases

EnsemblBacteriaiADC87583; ADC87583; SLGD_01492.
GeneIDi8819195.
KEGGislg:SLGD_01492.
PATRICi35306343. VBIStaLug155172_1430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001837 Genomic DNA. Translation: ADC87583.1.
RefSeqiYP_003471710.1. NC_013893.1.

3D structure databases

ProteinModelPortaliD3QCY0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC87583; ADC87583; SLGD_01492.
GeneIDi8819195.
KEGGislg:SLGD_01492.
PATRICi35306343. VBIStaLug155172_1430.

Phylogenomic databases

HOGENOMiHOG000280025.
KOiK01775.
OMAiVHLEYEN.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSLUG698737:GHG4-1489-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Staphylococcus lugdunensis strain HKU09-01."
    Tse H., Tsoi H.W., Leung S.P., Lau S.K., Woo P.C., Yuen K.Y.
    J. Bacteriol. 192:1471-1472(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKU09-01Imported.

Entry informationi

Entry nameiD3QCY0_STALH
AccessioniPrimary (citable) accession number: D3QCY0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.