D3Q6N0 (D3Q6N0_STANL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

Snas_4630

Organism

Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21) [Complete proteome] [HAMAP]

Taxonomic identifier

446470 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Glycomycineae › Glycomycetaceae › Stackebrandtia › Stackebrandtia nassauensis

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-kynurenine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3Q6N0 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 7BC55DD854AE93A8	FASTA	421	45,824
	10 20 30 40 50 60 MFSELHPEAD PATLDAADPL ASFRSEFAHD TEDLIYLDGN SLGRPPRAVL DAVRRVTDEE 70 80 90 100 110 120 WTNRLIRGWD EWIELPSRAG DALAADVVGA RPGEVLVCDS TSVNLYKLAA AALDAAPKGR 130 140 150 160 170 180 RVIVTDDDNF PTDRYILAGI AERHGGELRV IHTDIDEGVD PKTVAKAVKK DTALLCLSHV 190 200 210 220 230 240 SYRSGAIADM AAITERAHKS GAKVLWDLCH SAGAVPVELD ACGVDLAVGC TYKYLNAGPG 250 260 270 280 290 300 APAFLYVREE LQTRLRQPMW GWFSQTDQFA MGPEYLPRED IGRFAVGTPT VVGVAAVEAA 310 320 330 340 350 360 VAVTARAGVA ALREKSVRLG AYAQALFAEW LAPLGFELAS PDDPLRRGGH LTLAHKEAWR 370 380 390 400 410 420 IGQAMRARGV IPDYREPDRL RLGFAPLYNG YRDVHEGLSR VADIVRSGEY EKFPAEKGQV T

References

[1]

"Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21)." Munk C., Lapidus A., Copeland A., Jando M., Mayilraj S., Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F., Han C., Detter J.C., Bruce D., Goodwin L., Chain P., Pitluck S., Goker M. , Ovchinnikova G., Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 1:292-299(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001778 Genomic DNA. Translation: ADD44273.1.
RefSeq	YP_003513366.1. NC_013947.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADD44273; ADD44273; Snas_4630.
GeneID	8885835.
KEGG	sna:Snas_4630.
PATRIC	35371555. VBIStaNas43420_4581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000242437.
KO	K01556.
OMA	WGGRLIR.
Enzyme and pathway databases
BioCyc	SNAS446470:GHHC-4662-MONOMER.
UniPathway	UPA00253; UER00329. UPA00334; UER00455.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR14084. PTHR14084. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D3Q6N0_STANL

Accession

Primary (citable) accession number: D3Q6N0

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)