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D3Q6N0

- D3Q6N0_STANL

UniProt

D3Q6N0 - D3Q6N0_STANL

Protein

Kynureninase

Gene

kynU

Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
    Binding sitei207 – 2071Pyridoxal phosphateUniRule annotation
    Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
    Binding sitei232 – 2321Pyridoxal phosphateUniRule annotation
    Binding sitei262 – 2621Pyridoxal phosphateUniRule annotation
    Binding sitei288 – 2881Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciSNAS446470:GHHC-4662-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Snas_4630Imported
    OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)Imported
    Taxonomic identifieri446470 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesGlycomycineaeGlycomycetaceaeStackebrandtia
    ProteomesiUP000000844: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiHVAYRSA.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3Q6N0-1 [UniParc]FASTAAdd to Basket

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    MFSELHPEAD PATLDAADPL ASFRSEFAHD TEDLIYLDGN SLGRPPRAVL    50
    DAVRRVTDEE WTNRLIRGWD EWIELPSRAG DALAADVVGA RPGEVLVCDS 100
    TSVNLYKLAA AALDAAPKGR RVIVTDDDNF PTDRYILAGI AERHGGELRV 150
    IHTDIDEGVD PKTVAKAVKK DTALLCLSHV SYRSGAIADM AAITERAHKS 200
    GAKVLWDLCH SAGAVPVELD ACGVDLAVGC TYKYLNAGPG APAFLYVREE 250
    LQTRLRQPMW GWFSQTDQFA MGPEYLPRED IGRFAVGTPT VVGVAAVEAA 300
    VAVTARAGVA ALREKSVRLG AYAQALFAEW LAPLGFELAS PDDPLRRGGH 350
    LTLAHKEAWR IGQAMRARGV IPDYREPDRL RLGFAPLYNG YRDVHEGLSR 400
    VADIVRSGEY EKFPAEKGQV T 421
    Length:421
    Mass (Da):45,824
    Last modified:April 20, 2010 - v1
    Checksum:i7BC55DD854AE93A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001778 Genomic DNA. Translation: ADD44273.1.
    RefSeqiWP_013019844.1. NC_013947.1.
    YP_003513366.1. NC_013947.1.

    Genome annotation databases

    EnsemblBacteriaiADD44273; ADD44273; Snas_4630.
    GeneIDi8885835.
    KEGGisna:Snas_4630.
    PATRICi35371555. VBIStaNas43420_4581.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001778 Genomic DNA. Translation: ADD44273.1 .
    RefSeqi WP_013019844.1. NC_013947.1.
    YP_003513366.1. NC_013947.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD44273 ; ADD44273 ; Snas_4630 .
    GeneIDi 8885835.
    KEGGi sna:Snas_4630.
    PATRICi 35371555. VBIStaNas43420_4581.

    Phylogenomic databases

    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi HVAYRSA.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci SNAS446470:GHHC-4662-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21Imported.

    Entry informationi

    Entry nameiD3Q6N0_STANL
    AccessioniPrimary (citable) accession number: D3Q6N0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3