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Protein

Kynureninase

Gene

kynU

Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • pyridoxal 5'-phosphateUniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
Binding sitei207 – 2071Pyridoxal phosphateUniRule annotation
Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
Binding sitei232 – 2321Pyridoxal phosphateUniRule annotation
Binding sitei262 – 2621Pyridoxal phosphateUniRule annotation
Binding sitei288 – 2881Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSNAS446470:GHHC-4662-MONOMER.
UniPathwayiUPA00253; UER00329.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Snas_4630Imported
OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)Imported
Taxonomic identifieri446470 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesGlycomycineaeGlycomycetaceaeStackebrandtia
ProteomesiUP000000844: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiQPIQGWM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

D3Q6N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSELHPEAD PATLDAADPL ASFRSEFAHD TEDLIYLDGN SLGRPPRAVL
60 70 80 90 100
DAVRRVTDEE WTNRLIRGWD EWIELPSRAG DALAADVVGA RPGEVLVCDS
110 120 130 140 150
TSVNLYKLAA AALDAAPKGR RVIVTDDDNF PTDRYILAGI AERHGGELRV
160 170 180 190 200
IHTDIDEGVD PKTVAKAVKK DTALLCLSHV SYRSGAIADM AAITERAHKS
210 220 230 240 250
GAKVLWDLCH SAGAVPVELD ACGVDLAVGC TYKYLNAGPG APAFLYVREE
260 270 280 290 300
LQTRLRQPMW GWFSQTDQFA MGPEYLPRED IGRFAVGTPT VVGVAAVEAA
310 320 330 340 350
VAVTARAGVA ALREKSVRLG AYAQALFAEW LAPLGFELAS PDDPLRRGGH
360 370 380 390 400
LTLAHKEAWR IGQAMRARGV IPDYREPDRL RLGFAPLYNG YRDVHEGLSR
410 420
VADIVRSGEY EKFPAEKGQV T
Length:421
Mass (Da):45,824
Last modified:April 20, 2010 - v1
Checksum:i7BC55DD854AE93A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001778 Genomic DNA. Translation: ADD44273.1.
RefSeqiYP_003513366.1. NC_013947.1.

Genome annotation databases

EnsemblBacteriaiADD44273; ADD44273; Snas_4630.
GeneIDi8885835.
KEGGisna:Snas_4630.
PATRICi35371555. VBIStaNas43420_4581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001778 Genomic DNA. Translation: ADD44273.1.
RefSeqiYP_003513366.1. NC_013947.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADD44273; ADD44273; Snas_4630.
GeneIDi8885835.
KEGGisna:Snas_4630.
PATRICi35371555. VBIStaNas43420_4581.

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiQPIQGWM.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
BioCyciSNAS446470:GHHC-4662-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21Imported.

Entry informationi

Entry nameiD3Q6N0_STANL
AccessioniPrimary (citable) accession number: D3Q6N0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.