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Protein

Alanine racemase

Gene

Snas_0559

Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Snas_0559)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Active sitei259Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei307Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSNAS446470:G1GG8-561-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Snas_0559Imported
OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)Imported
Taxonomic identifieri446470 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaGlycomycetalesGlycomycetaceaeStackebrandtia
Proteomesi
  • UP000000844 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi446470.Snas_0559

Structurei

3D structure databases

ProteinModelPortaliD3Q5X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 362Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

D3Q5X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQAEAVVD LGTIAANVEA LAGRTSAAVM PALKANGYGH GLVPAARACL
60 70 80 90 100
DGGASRLGVA TLDEAMELRN SGVAAPILAW LVAPGLDLAA AVDADIELAV
110 120 130 140 150
ASREQLSAVA DAGARHPARI HLKADTGMGR GGAPRAEWQT LVDLAAKAQA
160 170 180 190 200
DGRIEIVGAF SHLACADEPG NPLTQSQDDN FRDFLDLLWA ADVQPQWQHL
210 220 230 240 250
ANSAGLLAHP DTHYNLVRPG IAVYGYPPVA TEAPLRPAMT LRARVVLVKT
260 270 280 290 300
LPAGHGIGYG HTYVTKRPTR VAIVPLGYAD GIPRSTSNRA EVLVGGRRCP
310 320 330 340 350
IRGRVSMDQV VVEVDEGDVR AGDVVEFFGD GDITAEDWAT WHDTISYEIL
360
TSIGPRIPRR YVGKNT
Length:366
Mass (Da):38,676
Last modified:April 20, 2010 - v1
Checksum:iF7ED3574017485C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001778 Genomic DNA Translation: ADD40273.1
RefSeqiWP_013015844.1, NC_013947.1

Genome annotation databases

EnsemblBacteriaiADD40273; ADD40273; Snas_0559
KEGGisna:Snas_0559

Entry informationi

Entry nameiD3Q5X4_STANL
AccessioniPrimary (citable) accession number: D3Q5X4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health