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D3Q5I2

- D3Q5I2_STANL

UniProt

D3Q5I2 - D3Q5I2_STANL

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Protein
D-alanine--D-alanine ligase
Gene
ddl, Snas_6426
Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation
Binds 2 magnesium or manganese ions per subunit By similarity.SAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Magnesium or manganese By similarityUniRule annotation
Metal bindingi277 – 2771Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 19256ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSNAS446470:GHHC-6479-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Snas_6426Imported
OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)Imported
Taxonomic identifieri446470 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesGlycomycineaeGlycomycetaceaeStackebrandtia
ProteomesiUP000000844: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3Q5I2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 310208ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiDYTARYT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00866. CPSASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Q5I2-1 [UniParc]FASTAAdd to Basket

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MRQDARVLVL AGGLSYEREV SLRSGRRVAD ALSRANVHAE LRDVDTNLLP    50
DLIADPPDAV VFALHGGNGE DGSLRSVLDL IGIPYVGPDA DAARRAWDKP 100
TAKALLRDAG LPTPEWIALP RETFSDLGAA KLLDRIVDKL GVPLAVKPAR 150
GGSGLGVAVV RTAEELPAAM IGCFAYGDVA LVEAFAPGKD IAVGVVDTGD 200
GPRVFPAVEI EPSGDAYDFA ARYNPGASTW HVPARLAPRV SEDVAAVATA 250
AFRTLGLRDL SRIDMMVPQA GPPLVLEAKV VPGMTETSLL PMACEAAGHD 300
LGELMAGLVD RAIARAK 317
Length:317
Mass (Da):33,201
Last modified:April 20, 2010 - v1
Checksum:iA356879F9F7E1C7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD46042.1.
RefSeqiWP_013021613.1. NC_013947.1.
YP_003515135.1. NC_013947.1.

Genome annotation databases

EnsemblBacteriaiADD46042; ADD46042; Snas_6426.
GeneIDi8887652.
KEGGisna:Snas_6426.
PATRICi35375203. VBIStaNas43420_6385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD46042.1 .
RefSeqi WP_013021613.1. NC_013947.1.
YP_003515135.1. NC_013947.1.

3D structure databases

ProteinModelPortali D3Q5I2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD46042 ; ADD46042 ; Snas_6426 .
GeneIDi 8887652.
KEGGi sna:Snas_6426.
PATRICi 35375203. VBIStaNas43420_6385.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi DYTARYT.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SNAS446470:GHHC-6479-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00866. CPSASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21.

Entry informationi

Entry nameiD3Q5I2_STANL
AccessioniPrimary (citable) accession number: D3Q5I2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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