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D3Q5I2

- D3Q5I2_STANL

UniProt

D3Q5I2 - D3Q5I2_STANL

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation
Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Magnesium or manganeseUniRule annotation
Metal bindingi277 – 2771Magnesium or manganeseUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 19256ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSNAS446470:GHHC-6479-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Snas_6426Imported
OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)Imported
Taxonomic identifieri446470 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesGlycomycineaeGlycomycetaceaeStackebrandtia
ProteomesiUP000000844: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3Q5I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 310208ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiDYTARYT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00866. CPSASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Q5I2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQDARVLVL AGGLSYEREV SLRSGRRVAD ALSRANVHAE LRDVDTNLLP
60 70 80 90 100
DLIADPPDAV VFALHGGNGE DGSLRSVLDL IGIPYVGPDA DAARRAWDKP
110 120 130 140 150
TAKALLRDAG LPTPEWIALP RETFSDLGAA KLLDRIVDKL GVPLAVKPAR
160 170 180 190 200
GGSGLGVAVV RTAEELPAAM IGCFAYGDVA LVEAFAPGKD IAVGVVDTGD
210 220 230 240 250
GPRVFPAVEI EPSGDAYDFA ARYNPGASTW HVPARLAPRV SEDVAAVATA
260 270 280 290 300
AFRTLGLRDL SRIDMMVPQA GPPLVLEAKV VPGMTETSLL PMACEAAGHD
310
LGELMAGLVD RAIARAK
Length:317
Mass (Da):33,201
Last modified:April 20, 2010 - v1
Checksum:iA356879F9F7E1C7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD46042.1.
RefSeqiWP_013021613.1. NC_013947.1.
YP_003515135.1. NC_013947.1.

Genome annotation databases

EnsemblBacteriaiADD46042; ADD46042; Snas_6426.
GeneIDi8887652.
KEGGisna:Snas_6426.
PATRICi35375203. VBIStaNas43420_6385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD46042.1 .
RefSeqi WP_013021613.1. NC_013947.1.
YP_003515135.1. NC_013947.1.

3D structure databases

ProteinModelPortali D3Q5I2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD46042 ; ADD46042 ; Snas_6426 .
GeneIDi 8887652.
KEGGi sna:Snas_6426.
PATRICi 35375203. VBIStaNas43420_6385.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi DYTARYT.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SNAS446470:GHHC-6479-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00866. CPSASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21Imported.

Entry informationi

Entry nameiD3Q5I2_STANL
AccessioniPrimary (citable) accession number: D3Q5I2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3