Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3Q557

- PSB_STANL

UniProt

D3Q557 - PSB_STANL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proteasome subunit beta

Gene

prcB

Organism
Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541NucleophileUniRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciSNAS446470:GHHC-4493-MONOMER.
UniPathwayiUPA00997.

Protein family/group databases

MEROPSiT01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PrcBUniRule annotation
Gene namesi
Name:prcBUniRule annotation
Ordered Locus Names:Snas_4461
OrganismiStackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
Taxonomic identifieri446470 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesGlycomycineaeGlycomycetaceaeStackebrandtia
ProteomesiUP000000844: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 5353Removed in mature form; by autocatalysisUniRule annotationPRO_0000397582Add
BLAST
Chaini54 – 279226Proteasome subunit betaPRO_0000397583Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245308.
KOiK03433.
OMAiFQVELEH.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_B. Proteasome_B_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3Q557-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTAEFPGR IPAPYLEVGS SSFVELLGSV APELLPGRRP LPPGDMGDAA
60 70 80 90 100
PHGTTIVALR CNEGVVMAGD RRATQGNMIS LRDIQKVFPA DAYSLIGIAG
110 120 130 140 150
TAGLGVEMIR LFQAELEHFE KLEGNALSLH GKANKLANMI RGNLGIAMQG
160 170 180 190 200
LAVLPLFAGF DTDAPDAASA GRIFSYDVVG GIYEEREYDA IGSGSIFAKS
210 220 230 240 250
ALKKRFQSEV DATEATRLAI EALYDAADDD SATGGPDLTR KLFPTVFTAT
260 270
ADGAKRVPDA EIEAVSRAVV AARLENPGG
Length:279
Mass (Da):29,238
Last modified:April 20, 2010 - v1
Checksum:i88B353FE5EF90906
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD44106.1.
RefSeqiYP_003513199.1. NC_013947.1.

Genome annotation databases

EnsemblBacteriaiADD44106; ADD44106; Snas_4461.
GeneIDi8885666.
KEGGisna:Snas_4461.
PATRICi35371221. VBIStaNas43420_4414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001778 Genomic DNA. Translation: ADD44106.1 .
RefSeqi YP_003513199.1. NC_013947.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD44106 ; ADD44106 ; Snas_4461 .
GeneIDi 8885666.
KEGGi sna:Snas_4461.
PATRICi 35371221. VBIStaNas43420_4414.

Phylogenomic databases

HOGENOMi HOG000245308.
KOi K03433.
OMAi FQVELEH.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci SNAS446470:GHHC-4493-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_B. Proteasome_B_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21.

Entry informationi

Entry nameiPSB_STANL
AccessioniPrimary (citable) accession number: D3Q557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3