D3PW91 (D3PW91_STANL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405

Gene names

Ordered Locus Names:

Snas_1545

Organism

Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21) [Complete proteome] [HAMAP]

Taxonomic identifier

446470 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Glycomycineae › Glycomycetaceae › Stackebrandtia › Stackebrandtia nassauensis

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS020922
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP-Rule MF_01405 SAAS SAAS020922
Ligand	Magnesium HAMAP-Rule MF_01405 SAAS SAAS020922 Manganese HAMAP-Rule MF_01405 SAAS SAAS020922 Metal-binding HAMAP-Rule MF_01405 SAAS SAAS020922 Nucleotide-binding HAMAP-Rule MF_01405 SAAS SAAS020922
Molecular function	Hydrolase HAMAP-Rule MF_01405 RuleBase RU003781 SAAS SAAS020922
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleoside triphosphate catabolic process Inferred from electronic annotation. Source: InterPro purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	7 – 12	6	Substrate binding By similarity HAMAP-Rule MF_01405
	Region	70 – 71	2	Substrate binding By similarity HAMAP-Rule MF_01405
Sites
	Metal binding	70	1	Magnesium or manganese By similarity HAMAP-Rule MF_01405
	Binding site	156	1	Substrate By similarity HAMAP-Rule MF_01405
	Binding site	176	1	Substrate By similarity HAMAP-Rule MF_01405
	Binding site	182	1	Substrate By similarity HAMAP-Rule MF_01405

Sequences

	Sequence		Length	Mass (Da)
	D3PW91 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: E559B636573CD7DC	FASTA	193	20,624
	10 20 30 40 50 60 MRLLLATRNR KKLTELERIL AEHSAVELVG LGDVEEYPEA PETALTFAGN ALAKARDAVR 70 80 90 100 110 120 HTGLTCVADD SGIAVDALNG MPGVFSARWA GRHGDDEANL ELLLGQLGDV PDEERGAAFV 130 140 150 160 170 180 CAAALVRPDG SEEVVHGEVR GRIIREPLGD NGFGYDPIFV PDGFAVTTAQ LSAVEKDAIS 190 HRGKAFRQLA KLL

References

[1]

"Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21)." Munk C., Lapidus A., Copeland A., Jando M., Mayilraj S., Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F., Han C., Detter J.C., Bruce D., Goodwin L., Chain P., Pitluck S., Goker M. , Ovchinnikova G., Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 1:292-299(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001778 Genomic DNA. Translation: ADD41248.1.
RefSeq	YP_003510341.1. NC_013947.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADD41248; ADD41248; Snas_1545.
GeneID	8882733.
KEGG	sna:Snas_1545.
PATRIC	35365421. VBIStaNas43420_1530.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000293319.
KO	K02428.
OMA	DGTLVWP.
Enzyme and pathway databases
BioCyc	SNAS446470:GHHC-1560-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase.
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
PANTHER	PTHR11067. PTHR11067. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D3PW91_STANL

Accession

Primary (citable) accession number: D3PW91

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)