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D3PS34

- D3PS34_MEIRD

UniProt

D3PS34 - D3PS34_MEIRD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Mrub_1505

Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciMRUB504728:GI6U-1541-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Mrub_1505Imported
    ORF Names:K649_15035Imported
    OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
    Taxonomic identifieri504728 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
    ProteomesiUP000013026: Chromosome, UP000006655: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3PS34-1 [UniParc]FASTAAdd to Basket

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    MAYQKISVPA GEKITIQDGK LHVPDQPIIG FIEGDGTGPD IWRAAQPVLD    50
    AAVAKAYGGR RKIAWAEIYA GEKANQVYGE PIWLPEETLE FIREYLVAIK 100
    GPLTTPVGGG IRSINVALRQ ELDLYACVRP VQWFEGVPSP VRHPELVNMV 150
    IFRENTEDIY AGIEFPKDSP EVKRFLEWFE AEFPKSYGKI RFPQTAGIGI 200
    KPVSEEGTHR LVEAAINYAI DNDLPSVTLV HKGNIMKYTE GAFRDWGYAL 250
    AKSKFGAVDL DGGPWQTITN PKTGRQIIIK DMIADNFLQQ ILLRPAEYSV 300
    IATLNLNGDY ISDALAAQVG GIGIAPGSNV NYYTGHAVFE ATHGTAPKYA 350
    GKDQVNPSSV ILSGEMMLRY MGWTEAADLI IQAMTKTIAQ GRVTYDFHRL 400
    MVAEGRNATL LKCSEFGQAL IENM 424
    Length:424
    Mass (Da):46,752
    Last modified:April 20, 2010 - v1
    Checksum:i3CDED4BC361F9E22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD28267.1.
    CP005385 Genomic DNA. Translation: AGK06293.1.
    RefSeqiWP_013013769.1. NC_021081.1.
    YP_003507287.1. NC_013946.1.
    YP_007881790.1. NC_021081.1.

    Genome annotation databases

    EnsemblBacteriaiADD28267; ADD28267; Mrub_1505.
    AGK06293; AGK06293; K649_15035.
    GeneIDi15337603.
    8879606.
    KEGGimrb:Mrub_1505.
    mre:K649_15035.
    PATRICi35359186. VBIMeiRub128672_1517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD28267.1 .
    CP005385 Genomic DNA. Translation: AGK06293.1 .
    RefSeqi WP_013013769.1. NC_021081.1.
    YP_003507287.1. NC_013946.1.
    YP_007881790.1. NC_021081.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD28267 ; ADD28267 ; Mrub_1505 .
    AGK06293 ; AGK06293 ; K649_15035 .
    GeneIDi 15337603.
    8879606.
    KEGGi mrb:Mrub_1505.
    mre:K649_15035.
    PATRICi 35359186. VBIMeiRub128672_1517.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci MRUB504728:GI6U-1541-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21Imported.
    2. "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
      Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.
    3. Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.

    Entry informationi

    Entry nameiD3PS34_MEIRD
    AccessioniPrimary (citable) accession number: D3PS34
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3