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D3PS34 (D3PS34_MEIRD) Unreviewed, UniProtKB/TrEMBL

Last modified January 22, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Mrub_1505 EMBL ADD28267.1
ORF Names:K649_15035 EMBL AGK06293.1
OrganismMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber) [Complete proteome] [HAMAP] EMBL ADD28267.1
Taxonomic identifier504728 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
D3PS34 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 3CDED4BC361F9E22

FASTA42446,752
        10         20         30         40         50         60 
MAYQKISVPA GEKITIQDGK LHVPDQPIIG FIEGDGTGPD IWRAAQPVLD AAVAKAYGGR 

        70         80         90        100        110        120 
RKIAWAEIYA GEKANQVYGE PIWLPEETLE FIREYLVAIK GPLTTPVGGG IRSINVALRQ 

       130        140        150        160        170        180 
ELDLYACVRP VQWFEGVPSP VRHPELVNMV IFRENTEDIY AGIEFPKDSP EVKRFLEWFE 

       190        200        210        220        230        240 
AEFPKSYGKI RFPQTAGIGI KPVSEEGTHR LVEAAINYAI DNDLPSVTLV HKGNIMKYTE 

       250        260        270        280        290        300 
GAFRDWGYAL AKSKFGAVDL DGGPWQTITN PKTGRQIIIK DMIADNFLQQ ILLRPAEYSV 

       310        320        330        340        350        360 
IATLNLNGDY ISDALAAQVG GIGIAPGSNV NYYTGHAVFE ATHGTAPKYA GKDQVNPSSV 

       370        380        390        400        410        420 
ILSGEMMLRY MGWTEAADLI IQAMTKTIAQ GRVTYDFHRL MVAEGRNATL LKCSEFGQAL 


IENM 

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References

« Hide 'large scale' references
[1]"Complete genome sequence of Meiothermus ruber type strain (21)."
Tindall B.J., Sikorski J., Lucas S., Goltsman E., Copeland A., Glavina Del Rio T., Nolan M., Tice H., Cheng J.F., Han C., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Fahnrich R., Goodwin L. expand/collapse author list , Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.
Stand. Genomic Sci. 3:26-36(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21.
[2]"Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 1279 EMBL AGK06293.1.
[3]Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 1279 EMBL AGK06293.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001743 Genomic DNA. Translation: ADD28267.1.
CP005385 Genomic DNA. Translation: AGK06293.1.
RefSeqYP_003507287.1. NC_013946.1.
YP_007881790.1. NC_021081.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD28267; ADD28267; Mrub_1505.
AGK06293; AGK06293; K649_15035.
GeneID15337603.
8879606.
KEGGmrb:Mrub_1505.
mre:K649_15035.
PATRIC35359186. VBIMeiRub128672_1517.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000021113.
KOK00031.
OMAFRDWGYE.

Enzyme and pathway databases

BioCycMRUB504728:GI6U-1541-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3PS34_MEIRD
AccessionPrimary (citable) accession number: D3PS34
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: January 22, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)