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D3PQU4

- D3PQU4_MEIRD

UniProt

D3PQU4 - D3PQU4_MEIRD

Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi12 – 121Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi48 – 481Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi77 – 771Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi143 – 1431Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi147 – 1471Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi150 – 1501Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP
    3. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
    2. RNA modification Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal proteinImported, TransferaseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMRUB504728:GI6U-1086-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.-.-.-UniRule annotation)
    Short name:
    S12 MTTaseUniRule annotation
    Short name:
    S12 methylthiotransferaseUniRule annotation
    Alternative name(s):
    Ribosome maturation factor RimOUniRule annotation
    Gene namesi
    Name:rimOUniRule annotationImported
    Ordered Locus Names:Mrub_1063Imported
    ORF Names:K649_04960Imported
    OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
    Taxonomic identifieri504728 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
    ProteomesiUP000006655: Chromosome, UP000013026: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 113111MTTase N-terminalUniRule annotationAdd
    BLAST
    Domaini369 – 43769TRAMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation
    Contains 1 MTTase N-terminal domain.UniRule annotation
    Contains 1 TRAM domain.UniRule annotation
    Contains MTTase N-terminal domain.SAAS annotation
    Contains TRAM domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000224766.
    KOiK14441.
    OMAiERYHRFM.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPiMF_01865. MTTase_RimO.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3PQU4-1 [UniParc]FASTAAdd to Basket

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    MAGKVGFVSL GCPKALVDSE QILSRLRAQG YETSPTYQEA DVVVVNTCGF    50
    ITPAVEESLT AIGEALSENG KVIVTGCLGA RPEVIQQAHP QVLEVTGPGE 100
    VDRVLAAVQR VVPLEQNPFT ALVPPQVKLT PRHYAYLKIA EGCNHKCSFC 150
    IIPKLRGLQQ SRDAAEILFE ATRLVGTGTK ELLVIAQDTS AYGVDIRHRT 200
    SDYAGKQVRA HLVDLVNELA GLGAWLRLHY VYPYPHVRDL IPLMAEGKLL 250
    PYLDVPLQHA SPRVLRAMRR PGGAESHLKT IQEWRAIAPD LAIRSSFIVG 300
    FPGETEEDFE LLLDFIAEAR LDRVGCFTYS EVEGADANSL PGAVPQEVKE 350
    ERRARLMALQ QQISLEKNQA RLGQTLEVIV DDYGELPGLV VGRSRYDAPG 400
    IDGLVYAETD GTVKIGDIIQ VRITQAEAYD LHGEMVGRVA WKPAVPVIKN 450
    VATETIQV 458
    Length:458
    Mass (Da):50,106
    Last modified:April 20, 2010 - v1
    Checksum:iB5CBD124ED5BC1F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD27827.1.
    CP005385 Genomic DNA. Translation: AGK04294.1.
    RefSeqiYP_003506847.1. NC_013946.1.
    YP_007879791.1. NC_021081.1.

    Genome annotation databases

    EnsemblBacteriaiADD27827; ADD27827; Mrub_1063.
    AGK04294; AGK04294; K649_04960.
    GeneIDi15335604.
    8879152.
    KEGGimrb:Mrub_1063.
    mre:K649_04960.
    PATRICi35358266. VBIMeiRub128672_1069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD27827.1 .
    CP005385 Genomic DNA. Translation: AGK04294.1 .
    RefSeqi YP_003506847.1. NC_013946.1.
    YP_007879791.1. NC_021081.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD27827 ; ADD27827 ; Mrub_1063 .
    AGK04294 ; AGK04294 ; K649_04960 .
    GeneIDi 15335604.
    8879152.
    KEGGi mrb:Mrub_1063.
    mre:K649_04960.
    PATRICi 35358266. VBIMeiRub128672_1069.

    Phylogenomic databases

    HOGENOMi HOG000224766.
    KOi K14441.
    OMAi ERYHRFM.

    Enzyme and pathway databases

    BioCyci MRUB504728:GI6U-1086-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPi MF_01865. MTTase_RimO.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21Imported.
    2. "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
      Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.
    3. Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.

    Entry informationi

    Entry nameiD3PQU4_MEIRD
    AccessioniPrimary (citable) accession number: D3PQU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3