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D3PQL0

- D3PQL0_MEIRD

UniProt

D3PQL0 - D3PQL0_MEIRD

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei105 – 1051NADUniRule annotation
Binding sitei112 – 1121NADUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Active sitei187 – 1871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NADUniRule annotation
Nucleotide bindingi129 – 1313NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciMRUB504728:GI6U-1000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Mrub_0978Imported
ORF Names:K649_04530Imported
OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
Taxonomic identifieri504728 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000006655: Chromosome, UP000013026: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3PQL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00024.
OMAiCALRDEV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3PQL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPPVRVAVT GAAGQIGYSL LFRIAAGEML GKDQPVILQL LEITPALKAL
60 70 80 90 100
GGVIMELEDC AFPTLAGIVA TDDPNIAFGD ADYALLVGAM PRKQGMERAD
110 120 130 140 150
LLQANGAIFT AQGRALSENA RKHVKVLVVG NPANTNALIT YKNAPNLSPR
160 170 180 190 200
QIHAMTRLDH NRAISQLAAR LKVPVSEIKK MTIWGNHSLT QYPDLFHCEV
210 220 230 240 250
GGRNAYELVG DHDWYANTYI PKVAKRGAEI IEARGASSAA SAASAAIDHM
260 270 280 290 300
RDWALGTPAG DWVSMAIPSD GSYGIPEGLV YSYPCVCKDG DFEIVQGLEI
310 320
NEFSRSKMDA SAKELADERD AVLQLGLIK
Length:329
Mass (Da):35,340
Last modified:April 20, 2010 - v1
Checksum:iC57E56BF6A0CC7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001743 Genomic DNA. Translation: ADD27743.1.
CP005385 Genomic DNA. Translation: AGK04208.1.
RefSeqiWP_013013262.1. NC_021081.1.
YP_003506763.1. NC_013946.1.
YP_007879705.1. NC_021081.1.

Genome annotation databases

EnsemblBacteriaiADD27743; ADD27743; Mrub_0978.
AGK04208; AGK04208; K649_04530.
GeneIDi15335518.
8879066.
KEGGimrb:Mrub_0978.
mre:K649_04530.
PATRICi35358092. VBIMeiRub128672_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001743 Genomic DNA. Translation: ADD27743.1 .
CP005385 Genomic DNA. Translation: AGK04208.1 .
RefSeqi WP_013013262.1. NC_021081.1.
YP_003506763.1. NC_013946.1.
YP_007879705.1. NC_021081.1.

3D structure databases

ProteinModelPortali D3PQL0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD27743 ; ADD27743 ; Mrub_0978 .
AGK04208 ; AGK04208 ; K649_04530 .
GeneIDi 15335518.
8879066.
KEGGi mrb:Mrub_0978.
mre:K649_04530.
PATRICi 35358092. VBIMeiRub128672_0983.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00024.
OMAi CALRDEV.

Enzyme and pathway databases

BioCyci MRUB504728:GI6U-1000-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21Imported.
  2. "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
    Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 1279Imported.
  3. Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 1279Imported.

Entry informationi

Entry nameiD3PQL0_MEIRD
AccessioniPrimary (citable) accession number: D3PQL0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3