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D3PQL0

- D3PQL0_MEIRD

UniProt

D3PQL0 - D3PQL0_MEIRD

Protein

Malate dehydrogenase

Gene

mdh

Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921SubstrateUniRule annotation
    Binding sitei98 – 981SubstrateUniRule annotation
    Binding sitei105 – 1051NADUniRule annotation
    Binding sitei112 – 1121NADUniRule annotation
    Binding sitei131 – 1311SubstrateUniRule annotation
    Binding sitei162 – 1621SubstrateUniRule annotation
    Active sitei187 – 1871Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 177NADUniRule annotation
    Nucleotide bindingi129 – 1313NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMRUB504728:GI6U-1000-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Mrub_0978Imported
    ORF Names:K649_04530Imported
    OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
    Taxonomic identifieri504728 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
    ProteomesiUP000006655: Chromosome, UP000013026: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiCALRDEV.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3PQL0-1 [UniParc]FASTAAdd to Basket

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    MKPPVRVAVT GAAGQIGYSL LFRIAAGEML GKDQPVILQL LEITPALKAL    50
    GGVIMELEDC AFPTLAGIVA TDDPNIAFGD ADYALLVGAM PRKQGMERAD 100
    LLQANGAIFT AQGRALSENA RKHVKVLVVG NPANTNALIT YKNAPNLSPR 150
    QIHAMTRLDH NRAISQLAAR LKVPVSEIKK MTIWGNHSLT QYPDLFHCEV 200
    GGRNAYELVG DHDWYANTYI PKVAKRGAEI IEARGASSAA SAASAAIDHM 250
    RDWALGTPAG DWVSMAIPSD GSYGIPEGLV YSYPCVCKDG DFEIVQGLEI 300
    NEFSRSKMDA SAKELADERD AVLQLGLIK 329
    Length:329
    Mass (Da):35,340
    Last modified:April 20, 2010 - v1
    Checksum:iC57E56BF6A0CC7DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD27743.1.
    CP005385 Genomic DNA. Translation: AGK04208.1.
    RefSeqiYP_003506763.1. NC_013946.1.
    YP_007879705.1. NC_021081.1.

    Genome annotation databases

    EnsemblBacteriaiADD27743; ADD27743; Mrub_0978.
    AGK04208; AGK04208; K649_04530.
    GeneIDi15335518.
    8879066.
    KEGGimrb:Mrub_0978.
    mre:K649_04530.
    PATRICi35358092. VBIMeiRub128672_0983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001743 Genomic DNA. Translation: ADD27743.1 .
    CP005385 Genomic DNA. Translation: AGK04208.1 .
    RefSeqi YP_003506763.1. NC_013946.1.
    YP_007879705.1. NC_021081.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD27743 ; ADD27743 ; Mrub_0978 .
    AGK04208 ; AGK04208 ; K649_04530 .
    GeneIDi 15335518.
    8879066.
    KEGGi mrb:Mrub_0978.
    mre:K649_04530.
    PATRICi 35358092. VBIMeiRub128672_0983.

    Phylogenomic databases

    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi CALRDEV.

    Enzyme and pathway databases

    BioCyci MRUB504728:GI6U-1000-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21Imported.
    2. "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
      Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.
    3. Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 1279Imported.

    Entry informationi

    Entry nameiD3PQL0_MEIRD
    AccessioniPrimary (citable) accession number: D3PQL0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3