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D3PQL0

- D3PQL0_MEIRD

UniProt

D3PQL0 - D3PQL0_MEIRD

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Protein
Malate dehydrogenase
Gene
mdh, Mrub_0978, K649_04530
Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarityUniRule annotation
Binding sitei98 – 981Substrate By similarityUniRule annotation
Binding sitei105 – 1051NAD By similarityUniRule annotation
Binding sitei112 – 1121NAD By similarityUniRule annotation
Binding sitei131 – 1311Substrate By similarityUniRule annotation
Binding sitei162 – 1621Substrate By similarityUniRule annotation
Active sitei187 – 1871Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarityUniRule annotation
Nucleotide bindingi129 – 1313NAD By similarityUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMRUB504728:GI6U-1000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Mrub_0978Imported
ORF Names:K649_04530Imported
OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
Taxonomic identifieri504728 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000006655: Chromosome, UP000013026: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00024.
OMAiCALRDEV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3PQL0-1 [UniParc]FASTAAdd to Basket

« Hide

MKPPVRVAVT GAAGQIGYSL LFRIAAGEML GKDQPVILQL LEITPALKAL    50
GGVIMELEDC AFPTLAGIVA TDDPNIAFGD ADYALLVGAM PRKQGMERAD 100
LLQANGAIFT AQGRALSENA RKHVKVLVVG NPANTNALIT YKNAPNLSPR 150
QIHAMTRLDH NRAISQLAAR LKVPVSEIKK MTIWGNHSLT QYPDLFHCEV 200
GGRNAYELVG DHDWYANTYI PKVAKRGAEI IEARGASSAA SAASAAIDHM 250
RDWALGTPAG DWVSMAIPSD GSYGIPEGLV YSYPCVCKDG DFEIVQGLEI 300
NEFSRSKMDA SAKELADERD AVLQLGLIK 329
Length:329
Mass (Da):35,340
Last modified:April 20, 2010 - v1
Checksum:iC57E56BF6A0CC7DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001743 Genomic DNA. Translation: ADD27743.1.
CP005385 Genomic DNA. Translation: AGK04208.1.
RefSeqiYP_003506763.1. NC_013946.1.
YP_007879705.1. NC_021081.1.

Genome annotation databases

EnsemblBacteriaiADD27743; ADD27743; Mrub_0978.
AGK04208; AGK04208; K649_04530.
GeneIDi15335518.
8879066.
KEGGimrb:Mrub_0978.
mre:K649_04530.
PATRICi35358092. VBIMeiRub128672_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001743 Genomic DNA. Translation: ADD27743.1 .
CP005385 Genomic DNA. Translation: AGK04208.1 .
RefSeqi YP_003506763.1. NC_013946.1.
YP_007879705.1. NC_021081.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD27743 ; ADD27743 ; Mrub_0978 .
AGK04208 ; AGK04208 ; K649_04530 .
GeneIDi 15335518.
8879066.
KEGGi mrb:Mrub_0978.
mre:K649_04530.
PATRICi 35358092. VBIMeiRub128672_0983.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00024.
OMAi CALRDEV.

Enzyme and pathway databases

BioCyci MRUB504728:GI6U-1000-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35948 / DSM 1279 / VKM B-1258 / 21.
  2. "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT Sequencing Data."
    Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J., Eichler E., Turner S.W.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 1279Imported.
  3. Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 1279Imported.

Entry informationi

Entry nameiD3PQL0_MEIRD
AccessioniPrimary (citable) accession number: D3PQL0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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