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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

K649_02010

Organism
Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
ORF Names:K649_02010Imported
OrganismiMeiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus ruber)Imported
Taxonomic identifieri504728 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
Proteomesi
  • UP000013026 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi504728.Mrub_0477

Structurei

3D structure databases

ProteinModelPortaliD3PMS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Lipoyl-bindingInterPro annotationAdd BLAST76
Domaini135 – 172Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281562
KOiK00627
OMAiSWRLGCD

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 2 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

D3PMS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELKLPDLG DNVTSAVVVG VLIKEGDTIA AGQPVLELET DKAVMEAPAS
60 70 80 90 100
EGGTVSKVLV KPGDEVKSGQ VIAVLGDAAP SAEKQEPKEK QEPKEEKAAP
110 120 130 140 150
APAPTPAPAA TPSAPAAAPR PPASAAPAGQ RRLIPAAPSV RRLAREMGIN
160 170 180 190 200
LMEVVGSGPA YRISENDLKR FAAGEAPTTA APQPSSAPAL PDFSKFGPVR
210 220 230 240 250
REAMSGVRRA TVRSMAQAWS TIPMVTHFDR ADITEMEALR KRMAPRAEQR
260 270 280 290 300
GAKVTMTAIL LKIAAAALKQ FPKFNASIDT ASNEIIYKDY IHIGVAVDTP
310 320 330 340 350
TGLLVPVVRD VDKKGVIALA KELGEIAAKA RERKLTPEEM QGATFTISNL
360 370 380 390 400
GGIGGTGFTP IVNWPEVAIM GVSRSSMEPV WSAEKGVFEP RNIMPFSLSY
410 420 430
DHRLIDGADA ARFCRFVAEL LEDPFLLGFE G
Length:431
Mass (Da):45,638
Last modified:April 20, 2010 - v1
Checksum:i3C4B8E18A02A81C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP005385 Genomic DNA Translation: AGK03706.1
RefSeqiWP_013012773.1, NC_021081.1

Genome annotation databases

EnsemblBacteriaiAGK03706; AGK03706; K649_02010
KEGGimrb:Mrub_0477
mre:K649_02010
PATRICifig|504728.9.peg.416

Similar proteinsi

Entry informationi

Entry nameiD3PMS9_MEIRD
AccessioniPrimary (citable) accession number: D3PMS9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health