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D3PDB4

- D3PDB4_DEFDS

UniProt

D3PDB4 - D3PDB4_DEFDS

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Protein

Alanine racemase

Gene

alr

Organism
Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Active sitei258 – 2581Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei306 – 3061Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDDES639282:GJ90-1108-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:DEFDS_1118Imported
OrganismiDeferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)Imported
Taxonomic identifieri639282 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceaeDeferribacter
ProteomesiUP000001520: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3PDB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiKSNTIPW.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3PDB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTKIKTLRP TYAEINLANY KHNIEVAKSL SKSKIIAIVK ADAYGHGAIK
60 70 80 90 100
LSKFAYEQCD VKDFGVATIE EGVNLRNVLP TDARIITLGY IDEHHFEELL
110 120 130 140 150
HHKITPTVFD KSIMAKLDKF AKGNNVVLDV VLKIDTGMNR LGFGLNTDFN
160 170 180 190 200
ELVESYSNLN IVLMMTHLSS SDTDLDYTKW QINRFDEYLK RYNVKAETSV
210 220 230 240 250
FNSSAICFYS NKYTYTRPGI MSYGYVYPEN RFGLKPVMSI YSKLIHIKRL
260 270 280 290 300
KKGEKISYNQ TFTASKDMKI GVIPIGYADG YFRALSNKGV MFVNGKPCNV
310 320 330 340 350
VGTVCMDMTM IDITHLNESD LDCEVEVLGK HIDAEQIAKM CNTISYEIVC
360
AISDRIPRVY INA
Length:363
Mass (Da):41,130
Last modified:April 20, 2010 - v1
Checksum:i98B483768899684C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011529 Genomic DNA. Translation: BAI80587.1.
RefSeqiYP_003496343.1. NC_013939.1.

Genome annotation databases

EnsemblBacteriaiBAI80587; BAI80587; DEFDS_1118.
GeneIDi8868465.
KEGGiddf:DEFDS_1118.
PATRICi35336181. VBIDefDes107323_1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011529 Genomic DNA. Translation: BAI80587.1 .
RefSeqi YP_003496343.1. NC_013939.1.

3D structure databases

ProteinModelPortali D3PDB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI80587 ; BAI80587 ; DEFDS_1118 .
GeneIDi 8868465.
KEGGi ddf:DEFDS_1118.
PATRICi 35336181. VBIDefDes107323_1118.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi KSNTIPW.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci DDES639282:GJ90-1108-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by the genome sequence of the thermophilic bacterium Deferribacter desulfuricans SSM1."
    Takaki Y., Shimamura S., Nakagawa S., Fukuhara Y., Horikawa H., Ankai A., Harada T., Hosoyama A., Oguchi A., Fukui S., Fujita N., Takami H., Takai K.
    DNA Res. 17:123-137(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14783 / JCM 11476 / NBRC 101012 / SSM1Imported.

Entry informationi

Entry nameiD3PDB4_DEFDS
AccessioniPrimary (citable) accession number: D3PDB4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3