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D3PDB4

- D3PDB4_DEFDS

UniProt

D3PDB4 - D3PDB4_DEFDS

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Protein
Alanine racemase
Gene
alr, DEFDS_1118
Organism
Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei140 – 1401Substrate By similarityUniRule annotation
Active sitei258 – 2581Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei306 – 3061Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciDDES639282:GJ90-1108-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:DEFDS_1118Imported
OrganismiDeferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)Imported
Taxonomic identifieri639282 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceaeDeferribacter
ProteomesiUP000001520: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3PDB4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiKSNTIPW.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3PDB4-1 [UniParc]FASTAAdd to Basket

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MLTKIKTLRP TYAEINLANY KHNIEVAKSL SKSKIIAIVK ADAYGHGAIK    50
LSKFAYEQCD VKDFGVATIE EGVNLRNVLP TDARIITLGY IDEHHFEELL 100
HHKITPTVFD KSIMAKLDKF AKGNNVVLDV VLKIDTGMNR LGFGLNTDFN 150
ELVESYSNLN IVLMMTHLSS SDTDLDYTKW QINRFDEYLK RYNVKAETSV 200
FNSSAICFYS NKYTYTRPGI MSYGYVYPEN RFGLKPVMSI YSKLIHIKRL 250
KKGEKISYNQ TFTASKDMKI GVIPIGYADG YFRALSNKGV MFVNGKPCNV 300
VGTVCMDMTM IDITHLNESD LDCEVEVLGK HIDAEQIAKM CNTISYEIVC 350
AISDRIPRVY INA 363
Length:363
Mass (Da):41,130
Last modified:April 20, 2010 - v1
Checksum:i98B483768899684C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011529 Genomic DNA. Translation: BAI80587.1.
RefSeqiYP_003496343.1. NC_013939.1.

Genome annotation databases

EnsemblBacteriaiBAI80587; BAI80587; DEFDS_1118.
GeneIDi8868465.
KEGGiddf:DEFDS_1118.
PATRICi35336181. VBIDefDes107323_1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011529 Genomic DNA. Translation: BAI80587.1 .
RefSeqi YP_003496343.1. NC_013939.1.

3D structure databases

ProteinModelPortali D3PDB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI80587 ; BAI80587 ; DEFDS_1118 .
GeneIDi 8868465.
KEGGi ddf:DEFDS_1118.
PATRICi 35336181. VBIDefDes107323_1118.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi KSNTIPW.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci DDES639282:GJ90-1108-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by the genome sequence of the thermophilic bacterium Deferribacter desulfuricans SSM1."
    Takaki Y., Shimamura S., Nakagawa S., Fukuhara Y., Horikawa H., Ankai A., Harada T., Hosoyama A., Oguchi A., Fukui S., Fujita N., Takami H., Takai K.
    DNA Res. 17:123-137(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14783 / JCM 11476 / NBRC 101012 / SSM1.

Entry informationi

Entry nameiD3PDB4_DEFDS
AccessioniPrimary (citable) accession number: D3PDB4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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