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Protein

Alanine racemase

Gene

alr

Organism
Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Active sitei258Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei306Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDDES639282:G1G36-1130-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:DEFDS_1118Imported
OrganismiDeferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)Imported
Taxonomic identifieri639282 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceaeDeferribacter
Proteomesi
  • UP000001520 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi639282.DEFDS_1118

Structurei

3D structure databases

ProteinModelPortaliD3PDB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 361Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.101 hit
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D3PDB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKIKTLRP TYAEINLANY KHNIEVAKSL SKSKIIAIVK ADAYGHGAIK
60 70 80 90 100
LSKFAYEQCD VKDFGVATIE EGVNLRNVLP TDARIITLGY IDEHHFEELL
110 120 130 140 150
HHKITPTVFD KSIMAKLDKF AKGNNVVLDV VLKIDTGMNR LGFGLNTDFN
160 170 180 190 200
ELVESYSNLN IVLMMTHLSS SDTDLDYTKW QINRFDEYLK RYNVKAETSV
210 220 230 240 250
FNSSAICFYS NKYTYTRPGI MSYGYVYPEN RFGLKPVMSI YSKLIHIKRL
260 270 280 290 300
KKGEKISYNQ TFTASKDMKI GVIPIGYADG YFRALSNKGV MFVNGKPCNV
310 320 330 340 350
VGTVCMDMTM IDITHLNESD LDCEVEVLGK HIDAEQIAKM CNTISYEIVC
360
AISDRIPRVY INA
Length:363
Mass (Da):41,130
Last modified:April 20, 2010 - v1
Checksum:i98B483768899684C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011529 Genomic DNA Translation: BAI80587.1
RefSeqiWP_013007834.1, NC_013939.1

Genome annotation databases

EnsemblBacteriaiBAI80587; BAI80587; DEFDS_1118
KEGGiddf:DEFDS_1118

Similar proteinsi

Entry informationi

Entry nameiD3PDB4_DEFDS
AccessioniPrimary (citable) accession number: D3PDB4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported