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D3PDB4

- D3PDB4_DEFDS

UniProt

D3PDB4 - D3PDB4_DEFDS

Protein

Alanine racemase

Gene

alr

Organism
Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei258 – 2581Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei306 – 3061Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDDES639282:GJ90-1108-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:DEFDS_1118Imported
    OrganismiDeferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)Imported
    Taxonomic identifieri639282 [NCBI]
    Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceaeDeferribacter
    ProteomesiUP000001520: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3PDB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiKSNTIPW.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3PDB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTKIKTLRP TYAEINLANY KHNIEVAKSL SKSKIIAIVK ADAYGHGAIK    50
    LSKFAYEQCD VKDFGVATIE EGVNLRNVLP TDARIITLGY IDEHHFEELL 100
    HHKITPTVFD KSIMAKLDKF AKGNNVVLDV VLKIDTGMNR LGFGLNTDFN 150
    ELVESYSNLN IVLMMTHLSS SDTDLDYTKW QINRFDEYLK RYNVKAETSV 200
    FNSSAICFYS NKYTYTRPGI MSYGYVYPEN RFGLKPVMSI YSKLIHIKRL 250
    KKGEKISYNQ TFTASKDMKI GVIPIGYADG YFRALSNKGV MFVNGKPCNV 300
    VGTVCMDMTM IDITHLNESD LDCEVEVLGK HIDAEQIAKM CNTISYEIVC 350
    AISDRIPRVY INA 363
    Length:363
    Mass (Da):41,130
    Last modified:April 20, 2010 - v1
    Checksum:i98B483768899684C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011529 Genomic DNA. Translation: BAI80587.1.
    RefSeqiYP_003496343.1. NC_013939.1.

    Genome annotation databases

    EnsemblBacteriaiBAI80587; BAI80587; DEFDS_1118.
    GeneIDi8868465.
    KEGGiddf:DEFDS_1118.
    PATRICi35336181. VBIDefDes107323_1118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011529 Genomic DNA. Translation: BAI80587.1 .
    RefSeqi YP_003496343.1. NC_013939.1.

    3D structure databases

    ProteinModelPortali D3PDB4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI80587 ; BAI80587 ; DEFDS_1118 .
    GeneIDi 8868465.
    KEGGi ddf:DEFDS_1118.
    PATRICi 35336181. VBIDefDes107323_1118.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi KSNTIPW.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci DDES639282:GJ90-1108-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by the genome sequence of the thermophilic bacterium Deferribacter desulfuricans SSM1."
      Takaki Y., Shimamura S., Nakagawa S., Fukuhara Y., Horikawa H., Ankai A., Harada T., Hosoyama A., Oguchi A., Fukui S., Fujita N., Takami H., Takai K.
      DNA Res. 17:123-137(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14783 / JCM 11476 / NBRC 101012 / SSM1Imported.

    Entry informationi

    Entry nameiD3PDB4_DEFDS
    AccessioniPrimary (citable) accession number: D3PDB4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3