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D3PA93 (D3PA93_DEFDS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length802 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
D3PA93 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: B0E132CB5309A3B9

FASTA80290,032
        10         20         30         40         50         60 
MKEKGIIEVN IEDSLKDSYL DYAMSVIIGR ALPDVRDGLK PVHRRVLYAM YEMGVLHNKP 

        70         80         90        100        110        120 
YKKSARIVGD VIGKYHPHGD SAVYDTLVRM AQDFSMRYPL VDGQGNFGSI DGDSAAAMRY 

       130        140        150        160        170        180 
TEVRMTKIAE EMLSDIDKDT VDFSPNYDGS LKEPVVLPTR IPNMLINGTS GIAVGMATNI 

       190        200        210        220        230        240 
PPHNLTEVID ALVYIIDNPS NTDEEILNFI KGPDFPTYGI IYGKDEILKA YKTGKGVIKV 

       250        260        270        280        290        300 
RAKVKKEITT TGKELLVVTE LPYQVNKANL IEKIANLARD KKINGIVDLR DESDRDGIRI 

       310        320        330        340        350        360 
VIELKRGENA DIIINQLYKF TQMEIAYGIN LVGIVNNKPK TLTLRDLLEQ FLEHRKVVVI 

       370        380        390        400        410        420 
RRTKFLLKKA EDRLHILEGL IKAVENIDEV VALIKSSKNA AEAKEKLMNR FELSDKQAQA 

       430        440        450        460        470        480 
ILDMRLHRLT GLEIEKLRNE YKETLKNIEF YKSILNNKSV LMGIIKEELI DIKNKYGDER 

       490        500        510        520        530        540 
RTQIVNSSEE INIEDLIPDD EVVVTLSYQG FIKRTPLSNF KSQKRGGKGK TGAGNVKEDF 

       550        560        570        580        590        600 
IKDILVTTNH STLMFFTNKG RIHYLKVYEL PELARDAKGK YIANLISLDK DEKVAAMIST 

       610        620        630        640        650        660 
KEFDRDRYIF MCTKEGIVKK TSLDAFSSGR SGIIAIKLRD GDEIVDASLI SKNDSIFIST 

       670        680        690        700        710        720 
RKGKCIQFNS SEVRNMGRNA TGVKGITLTK DDKVVSMEAV KGDPLILTVT TKGFGKSSLI 

       730        740        750        760        770        780 
TDYRIQSRGG KGIKLSKVTE RTGEIVGARQ VKLEDDVMLI SKSSKVIRLS VSDIPILGRD 

       790        800 
TQGVKLMGLD DEIISFDVIR ED

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References

[1]"Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by the genome sequence of the thermophilic bacterium Deferribacter desulfuricans SSM1."
Takaki Y., Shimamura S., Nakagawa S., Fukuhara Y., Horikawa H., Ankai A., Harada T., Hosoyama A., Oguchi A., Fukui S., Fujita N., Takami H., Takai K.
DNA Res. 17:123-137(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14783 / JCM 11476 / NBRC 101012 / SSM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011529 Genomic DNA. Translation: BAI79516.1.
RefSeqYP_003495272.1. NC_013939.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAI79516; BAI79516; DEFDS_0004.
GeneID8868300.
KEGGddf:DEFDS_0004.
PATRIC35333905. VBIDefDes107323_0004.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076279.
KOK02469.
OMAIAQEDVV.

Enzyme and pathway databases

BioCycDDES639282:GJ90-4-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3PA93_DEFDS
AccessionPrimary (citable) accession number: D3PA93
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info