SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3P4C7

- D3P4C7_AZOS1

UniProt

D3P4C7 - D3P4C7_AZOS1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Kynureninase
Gene
kynU, AZL_c02130
Organism
Azospirillum sp. (strain B510)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei86 – 861Pyridoxal phosphate By similarityUniRule annotation
Binding sitei155 – 1551Pyridoxal phosphate By similarityUniRule annotation
Binding sitei184 – 1841Pyridoxal phosphate By similarityUniRule annotation
Binding sitei187 – 1871Pyridoxal phosphate By similarityUniRule annotation
Binding sitei209 – 2091Pyridoxal phosphate By similarityUniRule annotation
Binding sitei239 – 2391Pyridoxal phosphate By similarityUniRule annotation
Binding sitei265 – 2651Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciASP137722:GBYD-4956-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:AZL_c02130Imported
Encoded oniPlasmid pAB510cImported
OrganismiAzospirillum sp. (strain B510)Imported
Taxonomic identifieri137722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum
ProteomesiUP000002040: Plasmid pAB510c

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3P4C7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1164Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

D3P4C7-1 [UniParc]FASTAAdd to Basket

« Hide

MTDFAKTRAR FDIPDGVIYL DGNSLGPLPI AAKERVARTL AEEWGGQLIR    50
GWNSAGWMVQ PRKVGDRIAR LIGAPAGSVV VGDTLSIKVY QALAAALAMR 100
PERRVILSDS GNFPTDLYMA EGLIETLGQG HILKVVAPEE VEGTIGEDVA 150
VLMLTEVDYR TGRLHDMAAL TAKAHAAGVV TVWDLAHSAG ALPVDLAGAG 200
TDFAVGCTYK YLNGGPGAPA FIYVAPQHAE RARPALSGWM GHEAPFAFDP 250
SYRPGAGVER MRVGTPPVIA LAALDAALDV WDDVDMADIR RTSMTLCDLF 300
IELVEAQCPT LELASPRDGS RRGSQVSFRH PQGYAIMQAL IDRGVIGDFR 350
APDVLRFGFT PLYIGEAEVR GAVAVLKQVT DGGLWDRPEY HRKAIVT 397
Length:397
Mass (Da):42,670
Last modified:April 20, 2010 - v1
Checksum:i7B9F4C078D5B12DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010949 Genomic DNA. Translation: BAI75506.1.
RefSeqiWP_012977337.1. NC_013857.1.
YP_003452050.1. NC_013857.1.

Genome annotation databases

EnsemblBacteriaiBAI75506; BAI75506; AZL_c02130.
GeneIDi8795090.
KEGGiazl:AZL_c02130.
PATRICi31939342. VBIAzoSp82869_5243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010949 Genomic DNA. Translation: BAI75506.1 .
RefSeqi WP_012977337.1. NC_013857.1.
YP_003452050.1. NC_013857.1.

3D structure databases

ProteinModelPortali D3P4C7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI75506 ; BAI75506 ; AZL_c02130 .
GeneIDi 8795090.
KEGGi azl:AZL_c02130.
PATRICi 31939342. VBIAzoSp82869_5243.

Phylogenomic databases

HOGENOMi HOG000242437.
KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci ASP137722:GBYD-4956-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B510Imported.
    Plasmid: pAB510c

Entry informationi

Entry nameiD3P4C7_AZOS1
AccessioniPrimary (citable) accession number: D3P4C7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported

External Data

Dasty 3

Similar proteinsi