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Protein

Kynureninase

Gene

kynU

Organism
Azospirillum sp. (strain B510)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei86 – 861Pyridoxal phosphateUniRule annotation
Binding sitei155 – 1551Pyridoxal phosphateUniRule annotation
Binding sitei184 – 1841Pyridoxal phosphateUniRule annotation
Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
Binding sitei209 – 2091Pyridoxal phosphateUniRule annotation
Binding sitei239 – 2391Pyridoxal phosphateUniRule annotation
Binding sitei265 – 2651Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciASP137722:GBYD-4956-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:AZL_c02130Imported
Encoded oniPlasmid pAB510cImported
OrganismiAzospirillum sp. (strain B510)Imported
Taxonomic identifieri137722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum
ProteomesiUP000002040 Componenti: Plasmid pAB510c

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3P4C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1164Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

D3P4C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFAKTRAR FDIPDGVIYL DGNSLGPLPI AAKERVARTL AEEWGGQLIR
60 70 80 90 100
GWNSAGWMVQ PRKVGDRIAR LIGAPAGSVV VGDTLSIKVY QALAAALAMR
110 120 130 140 150
PERRVILSDS GNFPTDLYMA EGLIETLGQG HILKVVAPEE VEGTIGEDVA
160 170 180 190 200
VLMLTEVDYR TGRLHDMAAL TAKAHAAGVV TVWDLAHSAG ALPVDLAGAG
210 220 230 240 250
TDFAVGCTYK YLNGGPGAPA FIYVAPQHAE RARPALSGWM GHEAPFAFDP
260 270 280 290 300
SYRPGAGVER MRVGTPPVIA LAALDAALDV WDDVDMADIR RTSMTLCDLF
310 320 330 340 350
IELVEAQCPT LELASPRDGS RRGSQVSFRH PQGYAIMQAL IDRGVIGDFR
360 370 380 390
APDVLRFGFT PLYIGEAEVR GAVAVLKQVT DGGLWDRPEY HRKAIVT
Length:397
Mass (Da):42,670
Last modified:April 20, 2010 - v1
Checksum:i7B9F4C078D5B12DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010949 Genomic DNA. Translation: BAI75506.1.
RefSeqiWP_012977337.1. NC_013857.1.
YP_003452050.1. NC_013857.1.

Genome annotation databases

EnsemblBacteriaiBAI75506; BAI75506; AZL_c02130.
KEGGiazl:AZL_c02130.
PATRICi31939342. VBIAzoSp82869_5243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010949 Genomic DNA. Translation: BAI75506.1.
RefSeqiWP_012977337.1. NC_013857.1.
YP_003452050.1. NC_013857.1.

3D structure databases

ProteinModelPortaliD3P4C7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI75506; BAI75506; AZL_c02130.
KEGGiazl:AZL_c02130.
PATRICi31939342. VBIAzoSp82869_5243.

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.
BioCyciASP137722:GBYD-4956-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B510Imported.

Entry informationi

Entry nameiD3P4C7_AZOS1
AccessioniPrimary (citable) accession number: D3P4C7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.