Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D3P4C7

- D3P4C7_AZOS1

UniProt

D3P4C7 - D3P4C7_AZOS1

Protein

Kynureninase

Gene

kynU

Organism
Azospirillum sp. (strain B510)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei86 – 861Pyridoxal phosphateUniRule annotation
    Binding sitei155 – 1551Pyridoxal phosphateUniRule annotation
    Binding sitei184 – 1841Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei209 – 2091Pyridoxal phosphateUniRule annotation
    Binding sitei239 – 2391Pyridoxal phosphateUniRule annotation
    Binding sitei265 – 2651Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciASP137722:GBYD-4956-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:AZL_c02130Imported
    Encoded oniPlasmid pAB510cImported
    OrganismiAzospirillum sp. (strain B510)Imported
    Taxonomic identifieri137722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum
    ProteomesiUP000002040: Plasmid pAB510c

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei210 – 2101N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3P4C7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 1164Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242437.
    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3P4C7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDFAKTRAR FDIPDGVIYL DGNSLGPLPI AAKERVARTL AEEWGGQLIR    50
    GWNSAGWMVQ PRKVGDRIAR LIGAPAGSVV VGDTLSIKVY QALAAALAMR 100
    PERRVILSDS GNFPTDLYMA EGLIETLGQG HILKVVAPEE VEGTIGEDVA 150
    VLMLTEVDYR TGRLHDMAAL TAKAHAAGVV TVWDLAHSAG ALPVDLAGAG 200
    TDFAVGCTYK YLNGGPGAPA FIYVAPQHAE RARPALSGWM GHEAPFAFDP 250
    SYRPGAGVER MRVGTPPVIA LAALDAALDV WDDVDMADIR RTSMTLCDLF 300
    IELVEAQCPT LELASPRDGS RRGSQVSFRH PQGYAIMQAL IDRGVIGDFR 350
    APDVLRFGFT PLYIGEAEVR GAVAVLKQVT DGGLWDRPEY HRKAIVT 397
    Length:397
    Mass (Da):42,670
    Last modified:April 20, 2010 - v1
    Checksum:i7B9F4C078D5B12DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010949 Genomic DNA. Translation: BAI75506.1.
    RefSeqiWP_012977337.1. NC_013857.1.
    YP_003452050.1. NC_013857.1.

    Genome annotation databases

    EnsemblBacteriaiBAI75506; BAI75506; AZL_c02130.
    GeneIDi8795090.
    KEGGiazl:AZL_c02130.
    PATRICi31939342. VBIAzoSp82869_5243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010949 Genomic DNA. Translation: BAI75506.1 .
    RefSeqi WP_012977337.1. NC_013857.1.
    YP_003452050.1. NC_013857.1.

    3D structure databases

    ProteinModelPortali D3P4C7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI75506 ; BAI75506 ; AZL_c02130 .
    GeneIDi 8795090.
    KEGGi azl:AZL_c02130.
    PATRICi 31939342. VBIAzoSp82869_5243.

    Phylogenomic databases

    HOGENOMi HOG000242437.
    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci ASP137722:GBYD-4956-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B510Imported.

    Entry informationi

    Entry nameiD3P4C7_AZOS1
    AccessioniPrimary (citable) accession number: D3P4C7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported, PlasmidImported

    External Data

    Dasty 3