ID   D3JZW5_HUMAN            Unreviewed;       143 AA.
AC   D3JZW5;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Parkin RBR E3 ubiquitin protein ligase {ECO:0000313|Ensembl:ENSP00000343589.4};
DE   SubName: Full=Truncated parkin variant SV4,8DEL {ECO:0000313|EMBL:ADB91978.1};
DE   SubName: Full=Truncated parkin variant SV4DEL {ECO:0000313|EMBL:ADB90269.1};
DE            EC=6.3.2.19 {ECO:0000313|EMBL:ADB90269.1, ECO:0000313|EMBL:ADB91978.1};
GN   Name=PRKN {ECO:0000313|Ensembl:ENSP00000343589.4};
GN   Synonyms=PARK2 {ECO:0000313|EMBL:ADB90269.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADB90269.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000343589.4, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:ADB90269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Retina {ECO:0000313|EMBL:ADB90269.1};
RA   Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.;
RT   "Homo sapiens PARK2 SV4DEL transcript variant.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ADB91978.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:ADB91978.1};
RA   Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.;
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000343589.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL035697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL078583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL132982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL138716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL445215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU345838; ADB90269.1; -; mRNA.
DR   EMBL; GU361466; ADB91978.1; -; mRNA.
DR   Ensembl; ENST00000338468.8; ENSP00000343589.4; ENSG00000185345.25.
DR   HGNC; HGNC:8607; PRKN.
DR   VEuPathDB; HostDB:ENSG00000185345; -.
DR   GeneTree; ENSGT00390000011034; -.
DR   ChiTaRS; PARK2; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000185345; Expressed in sural nerve and 107 other cell types or tissues.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   CDD; cd01798; Ubl_parkin; 1.
DR   InterPro; IPR015496; Ubiquilin.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   PANTHER; PTHR10677; UBIQUILIN; 1.
DR   PANTHER; PTHR10677:SF40; UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:D3JZW5,
KW   ECO:0007829|PeptideAtlas:D3JZW5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          1..72
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50053"
FT   REGION          77..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   143 AA;  15521 MW;  B97B8299DB799341 CRC64;
     MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD
     LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA
     VILHTDSRKD SPPAGSPGSI LLG
//