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Protein

Urea transporter 1

Gene

SLC14A1

Organism
Capra hircus (Goat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei334 – 3341Important for channel permeabilityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 1
Alternative name(s):
Solute carrier family 14 member 1
Urea transporter B
Short name:
UT-B
Urea transporter, erythrocyte
Gene namesi
Name:SLC14A1
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei47 – 6418HelicalBy similarityAdd
BLAST
Intramembranei68 – 8316HelicalBy similarityAdd
BLAST
Transmembranei86 – 10520HelicalBy similarityAdd
BLAST
Transmembranei110 – 13223HelicalBy similarityAdd
BLAST
Transmembranei139 – 16325HelicalBy similarityAdd
BLAST
Transmembranei168 – 18821HelicalBy similarityAdd
BLAST
Intramembranei215 – 22915HelicalBy similarityAdd
BLAST
Intramembranei234 – 24512HelicalBy similarityAdd
BLAST
Transmembranei250 – 26920HelicalBy similarityAdd
BLAST
Transmembranei279 – 29921HelicalBy similarityAdd
BLAST
Transmembranei304 – 32522HelicalBy similarityAdd
BLAST
Transmembranei328 – 34821HelicalBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Urea transporter 1PRO_0000410963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer; each subunit contains a pore through which urea permeates. Identified in a complex with STOM (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

D3INW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDNPTAVKL DQGGNQAPQG QGRRRLPKAL GYITGDMKEF ANWLKDKPQA
60 70 80 90 100
LQFVDWVLRG ISQVVFVSNP ISGILILVGL LVQNPWCALN GCVGTVVSTL
110 120 130 140 150
TALLLNQDRS AITAGLQGYN ATLVGILMAI YSDKGNYFWW LLFPVSAMSM
160 170 180 190 200
TCPIFSSALN SVLSKWDLPV FTLPFNMALS MYLSATGHYN PFFPSTLVTP
210 220 230 240 250
VTSVPNVTWP DLSALQLLKS LPVGVGQIYG CDNPWAGGIF LGAILLSSPL
260 270 280 290 300
MCLHAAIGSL LGIIAGLSLS APFENIYAGL WGFNSSLACI AIGGMFMALT
310 320 330 340 350
WQTHLLALAC ALFTAYLGAS MSHVMAVVGL PSCTWPFCLA TLLFLLLTTK
360 370 380
NPNIYKMPIS KVTYPEENRI FYLQSTKRTV QGPL
Length:384
Mass (Da):41,515
Last modified:March 23, 2010 - v1
Checksum:iC695A2F1E98B1ACA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ148778 mRNA. Translation: ADB79799.1.
RefSeqiXP_005697222.1. XM_005697165.1.
UniGeneiChi.961.

Genome annotation databases

GeneIDi100860878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ148778 mRNA. Translation: ADB79799.1.
RefSeqiXP_005697222.1. XM_005697165.1.
UniGeneiChi.961.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100860878.

Organism-specific databases

CTDi6563.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
PIRSFiPIRSF016502. Urea_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Effect of tea polyphenols on nitrogen metabolism of growing goats."
    Zeng J.Y., Zhong R.Z., Tan C.Y., Tang S.X., Han X.F., Xu Q., Yan Q.X., Wang M., Zhou C.S., Yuan Z.Q., Tan Z.L.
    Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUT1_CAPHI
AccessioniPrimary (citable) accession number: D3INW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: March 23, 2010
Last modified: July 22, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.