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D3INW7 (UT1_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Urea transporter 1
Alternative name(s):
Solute carrier family 14 member 1
Urea transporter B
Short name=UT-B
Urea transporter, erythrocyte
Gene names
Name:SLC14A1
OrganismCapra hircus (Goat)
Taxonomic identifier9925 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low-affinity facilitative urea transporter that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. the rate of urea conduction is increased by hypoosmotic stress. Mediates urea transport in erythrocytes By similarity.

Subunit structure

Homotrimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Cell membrane By similarity.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurea transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Urea transporter 1
PRO_0000410963

Regions

Transmembrane61 – 8121Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane327 – 34721Helical; Potential

Amino acid modifications

Glycosylation2061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D3INW7 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: C695A2F1E98B1ACA

FASTA38441,515
        10         20         30         40         50         60 
MDDNPTAVKL DQGGNQAPQG QGRRRLPKAL GYITGDMKEF ANWLKDKPQA LQFVDWVLRG 

        70         80         90        100        110        120 
ISQVVFVSNP ISGILILVGL LVQNPWCALN GCVGTVVSTL TALLLNQDRS AITAGLQGYN 

       130        140        150        160        170        180 
ATLVGILMAI YSDKGNYFWW LLFPVSAMSM TCPIFSSALN SVLSKWDLPV FTLPFNMALS 

       190        200        210        220        230        240 
MYLSATGHYN PFFPSTLVTP VTSVPNVTWP DLSALQLLKS LPVGVGQIYG CDNPWAGGIF 

       250        260        270        280        290        300 
LGAILLSSPL MCLHAAIGSL LGIIAGLSLS APFENIYAGL WGFNSSLACI AIGGMFMALT 

       310        320        330        340        350        360 
WQTHLLALAC ALFTAYLGAS MSHVMAVVGL PSCTWPFCLA TLLFLLLTTK NPNIYKMPIS 

       370        380 
KVTYPEENRI FYLQSTKRTV QGPL 

« Hide

References

[1]"Effect of tea polyphenols on nitrogen metabolism of growing goats."
Zeng J.Y., Zhong R.Z., Tan C.Y., Tang S.X., Han X.F., Xu Q., Yan Q.X., Wang M., Zhou C.S., Yuan Z.Q., Tan Z.L.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ148778 mRNA. Translation: ADB79799.1.
RefSeqXP_005697222.1. XM_005697165.1.
UniGeneChi.961.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100860878.
KEGGchx:100860878.

Organism-specific databases

CTD6563.

Phylogenomic databases

KOK08716.

Family and domain databases

InterProIPR004937. Urea_transporter.
[Graphical view]
PANTHERPTHR10464. PTHR10464. 1 hit.
PfamPF03253. UT. 1 hit.
[Graphical view]
PIRSFPIRSF016502. Urea_transporter. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUT1_CAPHI
AccessionPrimary (citable) accession number: D3INW7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program