ID   D3ICX3_9BACT            Unreviewed;       407 AA.
AC   D3ICX3;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   ORFNames=HMPREF0669_01277 {ECO:0000313|EMBL:EFC70822.1};
OS   Prevotella sp. oral taxon 299 str. F0039.
OG   Plasmid unnamed {ECO:0000313|EMBL:EFC70822.1}.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=575614 {ECO:0000313|EMBL:EFC70822.1, ECO:0000313|Proteomes:UP000015929};
RN   [1] {ECO:0000313|EMBL:EFC70822.1, ECO:0000313|Proteomes:UP000015929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0039 {ECO:0000313|EMBL:EFC70822.1,
RC   ECO:0000313|Proteomes:UP000015929};
RC   PLASMID=unnamed {ECO:0000313|EMBL:EFC70822.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA   Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA   Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFC70822.1, ECO:0000313|Proteomes:UP000015929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0039 {ECO:0000313|EMBL:EFC70822.1,
RC   ECO:0000313|Proteomes:UP000015929};
RC   PLASMID=Plasmid {ECO:0000313|Proteomes:UP000015929};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA   Blanton J.M., Tanner A.C., Dewhirst F.E., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Prevotella sp. Oral Taxon 299 strain F0039.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003667; EFC70822.1; -; Genomic_DNA.
DR   RefSeq; WP_009228453.1; NC_022111.1.
DR   AlphaFoldDB; D3ICX3; -.
DR   KEGG; pro:HMPREF0669_01277; -.
DR   HOGENOM; CLU_025267_1_0_10; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000015929; Plasmid.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Plasmid {ECO:0000313|EMBL:EFC70822.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..407
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003046572"
SQ   SEQUENCE   407 AA;  45303 MW;  89287B7106503E0B CRC64;
     MNRIYNLILL LGCTLSVAAQ TVLFKTDSVR KYPYRIPAIV NTIKGELITI VDYRPCGADI
     GYGRVDLVMK TSKDNGKTWS DEQIIIEGTG KGVDAGYGDA CLVADRKNNE LLLVCASGDI
     PYQRSTVEHP MRIETLRASY DNVKKQWVWT KPKDHTNEFY NKLFNNTNPS MFMSSGKVCQ
     SSIVKVGKYY RIYAALCTHK GNFVVYSDNF GDTWNVLGKA TESCAPQGDE VKCEELPDGS
     VIISSRKDGG RYFNIFHFKD LKKAIGTWEV EVDSRKAKGG IANAGTPCNG EILLIPAKEV
     LTGAKTYLLL QSIPAGPGRK NVSVYYKDMG SLVKNKKNRI SSMDIASDWN GVYKVSNTNS
     SYSTMCVQAD GKLGFFYEEA PKDLHELTYL PLSIETITAG KYTYRKK
//