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D3HN84

- D3HN84_LEGLN

UniProt

D3HN84 - D3HN84_LEGLN

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Protein
Thymidine kinase
Gene
tdk, LLO_0019
Organism
Legionella longbeachae serogroup 1 (strain NSW150)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLLON661367:GJAR-19-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:LLO_0019Imported
OrganismiLegionella longbeachae serogroup 1 (strain NSW150)Imported
Taxonomic identifieri661367 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001060: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3HN84.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3HN84-1 [UniParc]FASTAAdd to Basket

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MAKLYFYFAA MNAGKSTVLL QSSYNYRERG MQTLLFTPAV DNRYQQGVVH    50
SRIGLSEEAL IFNTDDDLYL KAMKQGQKYA CVLVDEAQFL TRAQVHQLTE 100
ITDQLGVPVL AYGLRTDFRG ELFEGSQYLL AWADELVELK TICHCGRKAT 150
MILRLNAQGD VITEGDQVVI GGNDMYSSTC RKHFKIRDPG ITKMHAELCE 200
KSIF 204
Length:204
Mass (Da):23,095
Last modified:March 23, 2010 - v1
Checksum:i775B170BD8B33F93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN650140 Genomic DNA. Translation: CBJ10340.1.
RefSeqiYP_003453510.1. NC_013861.1.

Genome annotation databases

EnsemblBacteriaiCBJ10340; CBJ10340; LLO_0019.
GeneIDi8799538.
KEGGillo:LLO_0019.
PATRICi35287998. VBILegLon159544_0018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN650140 Genomic DNA. Translation: CBJ10340.1 .
RefSeqi YP_003453510.1. NC_013861.1.

3D structure databases

ProteinModelPortali D3HN84.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ10340 ; CBJ10340 ; LLO_0019 .
GeneIDi 8799538.
KEGGi llo:LLO_0019.
PATRICi 35287998. VBILegLon159544_0018.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci LLON661367:GJAR-19-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease."
    Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D., Newton H.J., Sansom F.M., Jarraud S., Zidane N., Ma L., Bouchier C., Etienne J., Hartland E.L., Buchrieser C.
    PLoS Genet. 6:E1000851-E1000851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NSW150Imported.

Entry informationi

Entry nameiD3HN84_LEGLN
AccessioniPrimary (citable) accession number: D3HN84
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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