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D3HLG7

- D3HLG7_LEGLN

UniProt

D3HLG7 - D3HLG7_LEGLN

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Protein
Malate dehydrogenase
Gene
mdh, LLO_2851
Organism
Legionella longbeachae serogroup 1 (strain NSW150)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931Substrate By similarityUniRule annotation
Binding sitei99 – 991Substrate By similarityUniRule annotation
Binding sitei106 – 1061NAD By similarityUniRule annotation
Binding sitei113 – 1131NAD By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Binding sitei163 – 1631Substrate By similarityUniRule annotation
Active sitei188 – 1881Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NAD By similarityUniRule annotation
Nucleotide bindingi130 – 1323NAD By similarityUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLLON661367:GJAR-3065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:LLO_2851Imported
OrganismiLegionella longbeachae serogroup 1 (strain NSW150)Imported
Taxonomic identifieri661367 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001060: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3HLG7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00024.
OMAiHHCKVNM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3HLG7-1 [UniParc]FASTAAdd to Basket

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MANKRVRVAV TGAAGQIGYA LLFRIASGQM FGANTEVELN LLELEAALPS    50
LEGVAMELDD CAFPLLKRVV CTADMNKAMD GVNWALLVGS VPRKQGMERS 100
DLLQINGGIF TKQGLAINEH ASDDVRVFVV GNPCNTNCLI AMHHAKDVPN 150
DRFYAMTTLD ELRSRTQLAK KAGVDVTAVT QMTIWGNHSS TQYPDFYNAK 200
VNGVSAAQVI DEAWLKDTFV STVQQRGAAV IKARGSSSAA SAANAIVTGV 250
NHLVNDTPAG ESFSMCRCSE GEYGVDEGLI FSFPCRREQS QLKVVEGLTF 300
NDYGRDMFNK TLDELRQERD TVKSLGLLD 329
Length:329
Mass (Da):35,752
Last modified:March 23, 2010 - v1
Checksum:i59709173D30A7FF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN650140 Genomic DNA. Translation: CBJ13287.1.
RefSeqiYP_003456316.1. NC_013861.1.

Genome annotation databases

EnsemblBacteriaiCBJ13287; CBJ13287; LLO_2851.
GeneIDi8801439.
KEGGillo:LLO_2851.
PATRICi35293968. VBILegLon159544_2948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN650140 Genomic DNA. Translation: CBJ13287.1 .
RefSeqi YP_003456316.1. NC_013861.1.

3D structure databases

ProteinModelPortali D3HLG7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ13287 ; CBJ13287 ; LLO_2851 .
GeneIDi 8801439.
KEGGi llo:LLO_2851.
PATRICi 35293968. VBILegLon159544_2948.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00024.
OMAi HHCKVNM.

Enzyme and pathway databases

BioCyci LLON661367:GJAR-3065-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease."
    Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D., Newton H.J., Sansom F.M., Jarraud S., Zidane N., Ma L., Bouchier C., Etienne J., Hartland E.L., Buchrieser C.
    PLoS Genet. 6:E1000851-E1000851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NSW150Imported.

Entry informationi

Entry nameiD3HLG7_LEGLN
AccessioniPrimary (citable) accession number: D3HLG7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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