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Protein

Malate dehydrogenase

Gene

mdh

Organism
Legionella longbeachae serogroup 1 (strain NSW150)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciLLON661367:G1GKH-2930-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:LLO_2851Imported
OrganismiLegionella longbeachae serogroup 1 (strain NSW150)Imported
Taxonomic identifieri661367 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000001060 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi661367.LLO_2851

Structurei

3D structure databases

ProteinModelPortaliD3HLG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 148Ldh_1_NInterPro annotationAdd BLAST143
Domaini157 – 323Ldh_1_CInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

D3HLG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKRVRVAV TGAAGQIGYA LLFRIASGQM FGANTEVELN LLELEAALPS
60 70 80 90 100
LEGVAMELDD CAFPLLKRVV CTADMNKAMD GVNWALLVGS VPRKQGMERS
110 120 130 140 150
DLLQINGGIF TKQGLAINEH ASDDVRVFVV GNPCNTNCLI AMHHAKDVPN
160 170 180 190 200
DRFYAMTTLD ELRSRTQLAK KAGVDVTAVT QMTIWGNHSS TQYPDFYNAK
210 220 230 240 250
VNGVSAAQVI DEAWLKDTFV STVQQRGAAV IKARGSSSAA SAANAIVTGV
260 270 280 290 300
NHLVNDTPAG ESFSMCRCSE GEYGVDEGLI FSFPCRREQS QLKVVEGLTF
310 320
NDYGRDMFNK TLDELRQERD TVKSLGLLD
Length:329
Mass (Da):35,752
Last modified:March 23, 2010 - v1
Checksum:i59709173D30A7FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN650140 Genomic DNA Translation: CBJ13287.1
RefSeqiWP_003634998.1, NC_013861.1

Genome annotation databases

EnsemblBacteriaiCBJ13287; CBJ13287; LLO_2851
KEGGillo:LLO_2851

Similar proteinsi

Entry informationi

Entry nameiD3HLG7_LEGLN
AccessioniPrimary (citable) accession number: D3HLG7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health