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D3HLG7 (D3HLG7_LEGLN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01517 RuleBase RU000422

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP-Rule MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP-Rule MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP-Rule MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP-Rule MF_01517
Binding site931Substrate By similarity HAMAP-Rule MF_01517
Binding site991Substrate By similarity HAMAP-Rule MF_01517
Binding site1061NAD By similarity HAMAP-Rule MF_01517
Binding site1131NAD By similarity HAMAP-Rule MF_01517
Binding site1321Substrate By similarity HAMAP-Rule MF_01517
Binding site1631Substrate By similarity HAMAP-Rule MF_01517

Sequences

Sequence LengthMass (Da)Tools
D3HLG7 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: 59709173D30A7FF0

FASTA32935,752
        10         20         30         40         50         60 
MANKRVRVAV TGAAGQIGYA LLFRIASGQM FGANTEVELN LLELEAALPS LEGVAMELDD 

        70         80         90        100        110        120 
CAFPLLKRVV CTADMNKAMD GVNWALLVGS VPRKQGMERS DLLQINGGIF TKQGLAINEH 

       130        140        150        160        170        180 
ASDDVRVFVV GNPCNTNCLI AMHHAKDVPN DRFYAMTTLD ELRSRTQLAK KAGVDVTAVT 

       190        200        210        220        230        240 
QMTIWGNHSS TQYPDFYNAK VNGVSAAQVI DEAWLKDTFV STVQQRGAAV IKARGSSSAA 

       250        260        270        280        290        300 
SAANAIVTGV NHLVNDTPAG ESFSMCRCSE GEYGVDEGLI FSFPCRREQS QLKVVEGLTF 

       310        320 
NDYGRDMFNK TLDELRQERD TVKSLGLLD 

« Hide

References

[1]"Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease."
Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D., Newton H.J., Sansom F.M., Jarraud S., Zidane N., Ma L., Bouchier C., Etienne J., Hartland E.L., Buchrieser C.
PLoS Genet. 6:E1000851-E1000851(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NSW150 EMBL CBJ13287.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN650140 Genomic DNA. Translation: CBJ13287.1.
RefSeqYP_003456316.1. NC_013861.1.

3D structure databases

ProteinModelPortalD3HLG7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ13287; CBJ13287; LLO_2851.
GeneID8801439.
KEGGllo:LLO_2851.
PATRIC35293968. VBILegLon159544_2948.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000220953.
KOK00024.
OMAHHCKVNM.

Enzyme and pathway databases

BioCycLLON661367:GJAR-3065-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3HLG7_LEGLN
AccessionPrimary (citable) accession number: D3HLG7
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)