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D3HLG7

- D3HLG7_LEGLN

UniProt

D3HLG7 - D3HLG7_LEGLN

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Legionella longbeachae serogroup 1 (strain NSW150)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei99 – 991SubstrateUniRule annotation
Binding sitei106 – 1061NADUniRule annotation
Binding sitei113 – 1131NADUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Active sitei188 – 1881Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NADUniRule annotation
Nucleotide bindingi130 – 1323NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciLLON661367:GJAR-3065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:LLO_2851Imported
OrganismiLegionella longbeachae serogroup 1 (strain NSW150)Imported
Taxonomic identifieri661367 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001060: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3HLG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00024.
OMAiHHCKVNM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3HLG7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKRVRVAV TGAAGQIGYA LLFRIASGQM FGANTEVELN LLELEAALPS
60 70 80 90 100
LEGVAMELDD CAFPLLKRVV CTADMNKAMD GVNWALLVGS VPRKQGMERS
110 120 130 140 150
DLLQINGGIF TKQGLAINEH ASDDVRVFVV GNPCNTNCLI AMHHAKDVPN
160 170 180 190 200
DRFYAMTTLD ELRSRTQLAK KAGVDVTAVT QMTIWGNHSS TQYPDFYNAK
210 220 230 240 250
VNGVSAAQVI DEAWLKDTFV STVQQRGAAV IKARGSSSAA SAANAIVTGV
260 270 280 290 300
NHLVNDTPAG ESFSMCRCSE GEYGVDEGLI FSFPCRREQS QLKVVEGLTF
310 320
NDYGRDMFNK TLDELRQERD TVKSLGLLD
Length:329
Mass (Da):35,752
Last modified:March 23, 2010 - v1
Checksum:i59709173D30A7FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN650140 Genomic DNA. Translation: CBJ13287.1.
RefSeqiYP_003456316.1. NC_013861.1.

Genome annotation databases

EnsemblBacteriaiCBJ13287; CBJ13287; LLO_2851.
GeneIDi8801439.
KEGGillo:LLO_2851.
PATRICi35293968. VBILegLon159544_2948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN650140 Genomic DNA. Translation: CBJ13287.1 .
RefSeqi YP_003456316.1. NC_013861.1.

3D structure databases

ProteinModelPortali D3HLG7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ13287 ; CBJ13287 ; LLO_2851 .
GeneIDi 8801439.
KEGGi llo:LLO_2851.
PATRICi 35293968. VBILegLon159544_2948.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00024.
OMAi HHCKVNM.

Enzyme and pathway databases

BioCyci LLON661367:GJAR-3065-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease."
    Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D., Newton H.J., Sansom F.M., Jarraud S., Zidane N., Ma L., Bouchier C., Etienne J., Hartland E.L., Buchrieser C.
    PLoS Genet. 6:E1000851-E1000851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NSW150Imported.

Entry informationi

Entry nameiD3HLG7_LEGLN
AccessioniPrimary (citable) accession number: D3HLG7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3