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D3HCN5

- D3HCN5_STRG3

UniProt

D3HCN5 - D3HCN5_STRG3

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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Streptococcus gallolyticus (strain UCN34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi459 – 4591MagnesiumUniRule annotation
Metal bindingi465 – 4651Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi468 – 4681MagnesiumUniRule annotation
Metal bindingi469 – 4691MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSGAL637909:GJOV-1306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotationSAAS annotation (EC:6.1.1.20UniRule annotationSAAS annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Gene namesi
Name:pheTUniRule annotationImported
Ordered Locus Names:GALLO_0801Imported
OrganismiStreptococcus gallolyticus (strain UCN34)Imported
Taxonomic identifieri637909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001517: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3HCN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 153115tRNA-bindingUniRule annotationAdd
BLAST
Domaini406 – 48176B5UniRule annotationAdd
BLAST
Domaini708 – 80194FDX-ACBUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation
Contains 1 B5 domain.UniRule annotation
Contains 1 FDX-ACB domain.UniRule annotation
Contains 1 tRNA-binding domain.UniRule annotation
Contains B5 domain.SAAS annotation
Contains Bdomain.SAAS annotation
Contains FDX-ACB domain.SAAS annotation
Contains tRNA-binding domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000292087.
KOiK01890.
OMAiNYVMIEL.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3HCN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVSYKWLKE LVDVDVTTHE LSEKMSTTGI EVEGVSTPSE GLTKLVVGHV
60 70 80 90 100
VSCEDVPETH LHLCQVDTGD EELRQIVCGA PNVTAGINVI VAVPGARIAD
110 120 130 140 150
NYKIKKGKIR GMESLGMICS LQELGLPDSI IPKEFSDGIQ ILPEDAKPGD
160 170 180 190 200
SIFPYLDLDD EIVELSITPN RADALSMRGV AHEVAAIYGK EVHFPEKELK
210 220 230 240 250
EVSKAAKDVI NVAIESDKVL TYKARVVENV TVKPSPQWLQ NLLMNAGIRP
260 270 280 290 300
INNVVDVTNY VLLYFGQPMH AFDLNKFEDN KIVARNARAG EKLVTLDGEE
310 320 330 340 350
RELIAEDLVI TVADKPVALA GVMGGQATEI DDNSKNVVLE AAVFDGTSIR
360 370 380 390 400
KTSGRLNLRS ESSSRFEKGI NYATVAEALD FAAAMLTELA DGDVLAGRVE
410 420 430 440 450
AGSVPTEDVE VSTTLDYVNV RLGTELTYAD IEDVFAKLGF GLSGNADKFT
460 470 480 490 500
VSVPRRRWDI TIQADLVEEI ARIYGYDNLP TTLPEAAGTA GELTATQKLR
510 520 530 540 550
RKMRSIAEGA GLTEIVSYAL TTPEKATEFT LQPSNLTELM WPMSVERSVL
560 570 580 590 600
RQNVVSGMLD TVAYNVARKN SNLAIYEIGK VFEQKGNPKE ELPNEVSTFA
610 620 630 640 650
FAISGLVAEK DFQTKATPVD FFYAKGIVEA IFAKLDLTVD YVAEKGLASM
660 670 680 690 700
HPGRTASIYL DGQLVGFVGQ VHPQTAKNYN VPETYVAELN LDIIEAALHA
710 720 730 740 750
DKAFVEITKF PAVSRDIALL LPAATTHKEI LAAIESAKVK RLTDIKLFDV
760 770 780 790 800
YAGANIAEGM KSMAYSLTFQ NPNDNLTDEE VAKYMDKITK VLVNQLGAEV

R
Length:801
Mass (Da):87,370
Last modified:March 23, 2010 - v1
Checksum:iC661E83BA33B5871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN597254 Genomic DNA. Translation: CBI13293.1.
RefSeqiWP_012961766.1. NC_013798.1.
YP_003430228.1. NC_013798.1.

Genome annotation databases

EnsemblBacteriaiCBI13293; CBI13293; GALLO_0801.
GeneIDi8775677.
KEGGisga:GALLO_0801.
PATRICi35285025. VBIStrGal150982_0792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN597254 Genomic DNA. Translation: CBI13293.1 .
RefSeqi WP_012961766.1. NC_013798.1.
YP_003430228.1. NC_013798.1.

3D structure databases

ProteinModelPortali D3HCN5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI13293 ; CBI13293 ; GALLO_0801 .
GeneIDi 8775677.
KEGGi sga:GALLO_0801.
PATRICi 35285025. VBIStrGal150982_0792.

Phylogenomic databases

HOGENOMi HOG000292087.
KOi K01890.
OMAi NYVMIEL.

Enzyme and pathway databases

BioCyci SGAL637909:GJOV-1306-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis."
    Rusniok C., Couve E., Da Cunha V., El Gana R., Zidane N., Bouchier C., Poyart C., Leclercq R., Trieu-Cuot P., Glaser P.
    J. Bacteriol. 192:2266-2276(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCN34Imported.

Entry informationi

Entry nameiD3HCN5_STRG3
AccessioniPrimary (citable) accession number: D3HCN5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3