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D3HCN5

- D3HCN5_STRG3

UniProt

D3HCN5 - D3HCN5_STRG3

Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Streptococcus gallolyticus (strain UCN34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi459 – 4591MagnesiumUniRule annotation
    Metal bindingi465 – 4651Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi468 – 4681MagnesiumUniRule annotation
    Metal bindingi469 – 4691MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
    2. tRNA processing Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSGAL637909:GJOV-1306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
    Gene namesi
    Name:pheTUniRule annotationImported
    Ordered Locus Names:GALLO_0801Imported
    OrganismiStreptococcus gallolyticus (strain UCN34)Imported
    Taxonomic identifieri637909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001517: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3HCN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 153115tRNA-bindingUniRule annotationAdd
    BLAST
    Domaini406 – 48176B5UniRule annotationAdd
    BLAST
    Domaini708 – 80194FDX-ACBUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation
    Contains 1 B5 domain.UniRule annotation
    Contains 1 FDX-ACB domain.UniRule annotation
    Contains 1 tRNA-binding domain.UniRule annotation
    Contains B5 domain.SAAS annotation
    Contains Bdomain.SAAS annotation
    Contains FDX-ACB domain.SAAS annotation
    Contains tRNA-binding domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000292087.
    KOiK01890.
    OMAiNYVMIEL.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.30.56.20. 1 hit.
    3.30.70.380. 1 hit.
    3.50.40.10. 1 hit.
    HAMAPiMF_00283. Phe_tRNA_synth_beta1.
    InterProiIPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR012340. NA-bd_OB-fold.
    IPR004532. Phe-tRNA-ligase_IIc_bsu.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR005121. PheS_beta_Fdx_antiC-bd.
    IPR002547. tRNA-bd_dom.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view]
    PfamiPF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF03147. FDX-ACB. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    SM00896. FDX-ACB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54991. SSF54991. 1 hit.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
    PROSITEiPS51483. B5. 1 hit.
    PS51447. FDX_ACB. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3HCN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVSYKWLKE LVDVDVTTHE LSEKMSTTGI EVEGVSTPSE GLTKLVVGHV    50
    VSCEDVPETH LHLCQVDTGD EELRQIVCGA PNVTAGINVI VAVPGARIAD 100
    NYKIKKGKIR GMESLGMICS LQELGLPDSI IPKEFSDGIQ ILPEDAKPGD 150
    SIFPYLDLDD EIVELSITPN RADALSMRGV AHEVAAIYGK EVHFPEKELK 200
    EVSKAAKDVI NVAIESDKVL TYKARVVENV TVKPSPQWLQ NLLMNAGIRP 250
    INNVVDVTNY VLLYFGQPMH AFDLNKFEDN KIVARNARAG EKLVTLDGEE 300
    RELIAEDLVI TVADKPVALA GVMGGQATEI DDNSKNVVLE AAVFDGTSIR 350
    KTSGRLNLRS ESSSRFEKGI NYATVAEALD FAAAMLTELA DGDVLAGRVE 400
    AGSVPTEDVE VSTTLDYVNV RLGTELTYAD IEDVFAKLGF GLSGNADKFT 450
    VSVPRRRWDI TIQADLVEEI ARIYGYDNLP TTLPEAAGTA GELTATQKLR 500
    RKMRSIAEGA GLTEIVSYAL TTPEKATEFT LQPSNLTELM WPMSVERSVL 550
    RQNVVSGMLD TVAYNVARKN SNLAIYEIGK VFEQKGNPKE ELPNEVSTFA 600
    FAISGLVAEK DFQTKATPVD FFYAKGIVEA IFAKLDLTVD YVAEKGLASM 650
    HPGRTASIYL DGQLVGFVGQ VHPQTAKNYN VPETYVAELN LDIIEAALHA 700
    DKAFVEITKF PAVSRDIALL LPAATTHKEI LAAIESAKVK RLTDIKLFDV 750
    YAGANIAEGM KSMAYSLTFQ NPNDNLTDEE VAKYMDKITK VLVNQLGAEV 800
    R 801
    Length:801
    Mass (Da):87,370
    Last modified:March 23, 2010 - v1
    Checksum:iC661E83BA33B5871
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN597254 Genomic DNA. Translation: CBI13293.1.
    RefSeqiWP_012961766.1. NC_013798.1.
    YP_003430228.1. NC_013798.1.

    Genome annotation databases

    EnsemblBacteriaiCBI13293; CBI13293; GALLO_0801.
    GeneIDi8775677.
    KEGGisga:GALLO_0801.
    PATRICi35285025. VBIStrGal150982_0792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN597254 Genomic DNA. Translation: CBI13293.1 .
    RefSeqi WP_012961766.1. NC_013798.1.
    YP_003430228.1. NC_013798.1.

    3D structure databases

    ProteinModelPortali D3HCN5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBI13293 ; CBI13293 ; GALLO_0801 .
    GeneIDi 8775677.
    KEGGi sga:GALLO_0801.
    PATRICi 35285025. VBIStrGal150982_0792.

    Phylogenomic databases

    HOGENOMi HOG000292087.
    KOi K01890.
    OMAi NYVMIEL.

    Enzyme and pathway databases

    BioCyci SGAL637909:GJOV-1306-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.30.56.20. 1 hit.
    3.30.70.380. 1 hit.
    3.50.40.10. 1 hit.
    HAMAPi MF_00283. Phe_tRNA_synth_beta1.
    InterProi IPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR012340. NA-bd_OB-fold.
    IPR004532. Phe-tRNA-ligase_IIc_bsu.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR005121. PheS_beta_Fdx_antiC-bd.
    IPR002547. tRNA-bd_dom.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view ]
    Pfami PF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF03147. FDX-ACB. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    SM00896. FDX-ACB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54991. SSF54991. 1 hit.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
    PROSITEi PS51483. B5. 1 hit.
    PS51447. FDX_ACB. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis."
      Rusniok C., Couve E., Da Cunha V., El Gana R., Zidane N., Bouchier C., Poyart C., Leclercq R., Trieu-Cuot P., Glaser P.
      J. Bacteriol. 192:2266-2276(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCN34Imported.

    Entry informationi

    Entry nameiD3HCN5_STRG3
    AccessioniPrimary (citable) accession number: D3HCN5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3