Skip Header

Contribute Send feedback
Read comments (?) or add your own

D3HC61 (D3HC61_STRG3) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
3-methyl-2-oxobutanoate hydroxymethyltransferase HAMAP-Rule MF_00156
EC=2.1.2.11 HAMAP-Rule MF_00156
Alternative name(s):
Ketopantoate hydroxymethyltransferase HAMAP-Rule MF_00156
Gene names
Name:panB HAMAP-Rule MF_00156 EMBL CBI12653.1
Ordered Locus Names:GALLO_0161
OrganismStreptococcus gallolyticus (strain UCN34) [Complete proteome] [HAMAP]
Taxonomic identifier637909 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate By similarity. HAMAP-Rule MF_00156 SAAS SAAS003700

Catalytic activity

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate. HAMAP-Rule MF_00156 SAAS SAAS003700

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00156 SAAS SAAS003700

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2. HAMAP-Rule MF_00156 SAAS SAAS003700

Subunit structure

Homodecamer; pentamer of dimers By similarity. HAMAP-Rule MF_00156 SAAS SAAS003700

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00156 SAAS SAAS003700.

Sequence similarities

Belongs to the PanB family. HAMAP-Rule MF_00156

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region44 – 452Alpha-ketoisovalerate binding By similarity HAMAP-Rule MF_00156

Sites

Active site1821Proton acceptor By similarity HAMAP-Rule MF_00156
Metal binding441Magnesium By similarity HAMAP-Rule MF_00156
Metal binding831Magnesium By similarity HAMAP-Rule MF_00156
Metal binding1151Magnesium By similarity HAMAP-Rule MF_00156
Binding site831Alpha-ketoisovalerate By similarity HAMAP-Rule MF_00156
Binding site1131Alpha-ketoisovalerate By similarity HAMAP-Rule MF_00156

Sequences

Sequence LengthMass (Da)Tools
D3HC61 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: BEA8C4D5E95EF34B

FASTA27529,661
        10         20         30         40         50         60 
MKNTVLSFQR AKKDGKKLTM LTAYDYSTAK LIDSTGINSI LVGDSLGNVV LGYDDTVSVT 

        70         80         90        100        110        120 
LDDMIHHGKA VCRGAKNALV IVDMPFMSYQ ISVEQALENA GRLMKETHCQ AVKLEGGKSV 

       130        140        150        160        170        180 
CPQIKAMVEA GIPVCAHLGL TPQHINAFGG FKVQGRTEAA AKQLIEDAKA VQEAGAFAVV 

       190        200        210        220        230        240 
LEAIPAELAQ LITKQLDIPT IGIGAGNQTD GQVLVYADLL GLFSDFTPKF VKRYANIGEL 

       250        260        270 
ISGAVKNYID DVATQKFPTP ENEYHIDDTI IEKLY

« Hide

References

[1]"Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis."
Rusniok C., Couve E., Da Cunha V., El Gana R., Zidane N., Bouchier C., Poyart C., Leclercq R., Trieu-Cuot P., Glaser P.
J. Bacteriol. 192:2266-2276(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UCN34.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN597254 Genomic DNA. Translation: CBI12653.1.
RefSeqYP_003429603.1. NC_013798.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBI12653; CBI12653; GALLO_0161.
GeneID8777184.
KEGGsga:GALLO_0161.
PATRIC35283679. VBIStrGal150982_0158.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000078427.
KOK00606.
OMACYDASFA.

Enzyme and pathway databases

UniPathwayUPA00028; UER00003.

Family and domain databases

Gene3D3.20.20.60. 1 hit.
HAMAPMF_00156. PanB.
InterProIPR003700. Pantoate_hydroxy_MeTrfase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR20881. PTHR20881. 1 hit.
PfamPF02548. Pantoate_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000388. Pantoate_hydroxy_MeTrfase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR00222. panB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3HC61_STRG3
AccessionPrimary (citable) accession number: D3HC61
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 29, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info