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D3H7M2 (D3H7M2_STRM6) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddL EMBL CBJ21864.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:smi_0615 EMBL CBJ21864.1
OrganismStreptococcus mitis (strain B6) [Complete proteome] [HAMAP]
Taxonomic identifier365659 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain131 – 333203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding161 – 21656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2871Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3021Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D3H7M2 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: D4A5086ED81D479B

FASTA34738,825
        10         20         30         40         50         60 
MKQTIILLYG GRSAEREVSV LSAESVMRAV NYDRFTVKTF FISQSGDFIK TQEFSQTPGQ 

        70         80         90        100        110        120 
EDRLMTNETI DWDKQVAPSA IYEEGAVVFP VLHGPMGEDG SVQGFLEVLK MPYVGCNILS 

       130        140        150        160        170        180 
SSLAMDKITT KRVLESVGIA QVPYVAIVEG DDVTSKITEV EEKLNYPVFT KPSNMGSSVG 

       190        200        210        220        230        240 
ISKSENQEEL RQALKLAFQY DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY 

       250        260        270        280        290        300 
DYDAKYIDNK ITMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE 

       310        320        330        340 
LNTMPGFTQW SMYPLLWDNM GISYPELIER LVELAKESFV KREAHLL 

« Hide

References

[1]"The genome of Streptococcus mitis B6--what is a commensal?"
Denapaite D., Bruckner R., Nuhn M., Reichmann P., Henrich B., Maurer P., Schahle Y., Selbmann P., Zimmermann W., Wambutt R., Hakenbeck R.
PLoS ONE 5:E9426-E9426(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN568063 Genomic DNA. Translation: CBJ21864.1.
RefSeqYP_003445732.1. NC_013853.1.

3D structure databases

ProteinModelPortalD3H7M2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ21864; CBJ21864; smi_0615.
GeneID8799235.
KEGGsmb:smi_0615.
PATRIC32454135. VBIStrMit3699_0586.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3H7M2_STRM6
AccessionPrimary (citable) accession number: D3H7M2
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)