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Protein

D-alanine--D-alanine ligase

Gene

ddL

Organism
Streptococcus mitis (strain B6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Magnesium or manganese 1UniRule annotation1
Metal bindingi300Magnesium or manganese 1UniRule annotation1
Metal bindingi300Magnesium or manganese 2UniRule annotation1
Metal bindingi302Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddLImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:smi_0615Imported
OrganismiStreptococcus mitis (strain B6)Imported
Taxonomic identifieri365659 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000008563 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi365659.smi_0615.

Structurei

3D structure databases

ProteinModelPortaliD3H7M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 333ATP-graspInterPro annotationAdd BLAST203

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D3H7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTIILLYG GRSAEREVSV LSAESVMRAV NYDRFTVKTF FISQSGDFIK
60 70 80 90 100
TQEFSQTPGQ EDRLMTNETI DWDKQVAPSA IYEEGAVVFP VLHGPMGEDG
110 120 130 140 150
SVQGFLEVLK MPYVGCNILS SSLAMDKITT KRVLESVGIA QVPYVAIVEG
160 170 180 190 200
DDVTSKITEV EEKLNYPVFT KPSNMGSSVG ISKSENQEEL RQALKLAFQY
210 220 230 240 250
DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY DYDAKYIDNK
260 270 280 290 300
ITMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE
310 320 330 340
LNTMPGFTQW SMYPLLWDNM GISYPELIER LVELAKESFV KREAHLL
Length:347
Mass (Da):38,825
Last modified:March 23, 2010 - v1
Checksum:iD4A5086ED81D479B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN568063 Genomic DNA. Translation: CBJ21864.1.
RefSeqiWP_000814687.1. NC_013853.1.
YP_003445732.1. NC_013853.1.

Genome annotation databases

EnsemblBacteriaiCBJ21864; CBJ21864; smi_0615.
GeneIDi8799235.
KEGGismb:smi_0615.
PATRICifig|365659.3.peg.586.

Similar proteinsi

Entry informationi

Entry nameiD3H7M2_STRM6
AccessioniPrimary (citable) accession number: D3H7M2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 27, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported