ID   IFNG_CHICK              Reviewed;         164 AA.
AC   P49708; D3GGX1; Q53YS2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=Interferon gamma;
DE            Short=IFN-gamma;
DE   Flags: Precursor;
GN   Name=IFNG;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8590305; DOI=10.1089/jir.1995.15.939;
RA   Digby M.R., Lowenthal J.W.;
RT   "Cloning and expression of the chicken interferon-gamma gene.";
RL   J. Interferon Cytokine Res. 15:939-945(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8898958; DOI=10.1002/eji.1830261026;
RA   Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.;
RT   "Biological properties of recombinant chicken interferon-gamma.";
RL   Eur. J. Immunol. 26:2440-2447(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N LINE;
RX   PubMed=9511740; DOI=10.1016/s0378-1119(97)00600-8;
RA   Kaiser P., Wain H.M., Rothwell L.;
RT   "Structure of the chicken interferon-gamma gene, and comparison to
RT   mammalian homologues.";
RL   Gene 207:25-32(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=White leghorn; TISSUE=Spleen;
RA   Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.;
RT   "Molecular genetic analysis of chicken interferon gamma gene.";
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RA   Lv Y.Z., Cao Y.C., Bi Y.Z.;
RT   "Chicken interferon-gamma.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RA   Bao M., Zhong D., Xu F., Yu W.;
RT   "Cloning and expression of the chicken interferon-gamma gene.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peripheral blood lymphocyte;
RA   Zhang X., Zhang C., Li Y., Cheng X., Wu T.;
RT   "Cloning and sequence analysis of interferon gamma of China Lushi
RT   chicken.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by lymphocytes activated by specific antigens or
CC       mitogens. IFN-gamma, in addition to having antiviral activity, has
CC       important immunoregulatory functions. It is a potent activator of
CC       macrophages, it has antiproliferative effects on transformed cells and
CC       it can potentiate the antiviral and antitumor effects of the type I
CC       interferons (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; U27465; AAC59723.1; -; mRNA.
DR   EMBL; X99774; CAA68118.1; -; mRNA.
DR   EMBL; Y07922; CAA69227.1; -; Genomic_DNA.
DR   EMBL; U96875; AAG27918.1; -; Genomic_DNA.
DR   EMBL; U96872; AAG27918.1; JOINED; Genomic_DNA.
DR   EMBL; U96873; AAG27918.1; JOINED; Genomic_DNA.
DR   EMBL; U96874; AAG27918.1; JOINED; Genomic_DNA.
DR   EMBL; AF424744; AAL17845.1; -; mRNA.
DR   EMBL; AY501004; AAR98863.1; -; mRNA.
DR   EMBL; FJ788637; ACY72343.1; -; mRNA.
DR   PIR; JC6536; JC6536.
DR   RefSeq; NP_990480.1; NM_205149.1.
DR   AlphaFoldDB; P49708; -.
DR   SMR; P49708; -.
DR   STRING; 9031.ENSGALP00000016086; -.
DR   GlyCosmos; P49708; 2 sites, No reported glycans.
DR   PaxDb; 9031-ENSGALP00000016086; -.
DR   Ensembl; ENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
DR   Ensembl; ENSGALT00010028555.1; ENSGALP00010016393.1; ENSGALG00010011933.1.
DR   Ensembl; ENSGALT00015035002; ENSGALP00015020348; ENSGALG00015014339.
DR   GeneID; 396054; -.
DR   KEGG; gga:396054; -.
DR   CTD; 3458; -.
DR   VEuPathDB; HostDB:geneid_396054; -.
DR   eggNOG; ENOG502SBGW; Eukaryota.
DR   GeneTree; ENSGT00390000007831; -.
DR   HOGENOM; CLU_135106_0_0_1; -.
DR   InParanoid; P49708; -.
DR   OMA; QIVSMYL; -.
DR   OrthoDB; 5314434at2759; -.
DR   PhylomeDB; P49708; -.
DR   TreeFam; TF336308; -.
DR   Reactome; R-GGA-877300; Interferon gamma signaling.
DR   Reactome; R-GGA-877312; Regulation of IFNG signaling.
DR   Reactome; R-GGA-9732724; IFNG signaling activates MAPKs.
DR   PRO; PR:P49708; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000009903; Expressed in granulocyte and 6 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005133; F:type II interferon receptor binding; IEA:InterPro.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0140374; P:antiviral innate immune response; IDA:GO_Central.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0042116; P:macrophage activation; IDA:AgBase.
DR   GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IDA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR   GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; TAS:AgBase.
DR   GO; GO:0070673; P:response to interleukin-18; IDA:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; INTERFERON GAMMA; 1.
DR   PANTHER; PTHR11419:SF0; INTERFERON GAMMA; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..164
FT                   /note="Interferon gamma"
FT                   /id="PRO_0000016463"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  18953 MW;  18D9B0BCA415B600 CRC64;
     MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD GGPIIVEKLK
     NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL YTLKNNLPDG VKKVKDIMDL
     AKLPMNDLRI QRKAANELFS ILQKLVDPPS FKRKRSQSQR RCNC
//