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D3GGX1

- D3GGX1_CHICK

UniProt

D3GGX1 - D3GGX1_CHICK

Protein

Interferon gamma

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.UniRule annotation

    GO - Biological processi

    1. adaptive immune response Source: Ensembl
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: UniProtKB-KW
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: Ensembl
    13. negative regulation of growth of symbiont in host Source: Ensembl
    14. negative regulation of interleukin-17 production Source: Ensembl
    15. negative regulation of myelination Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. neutrophil apoptotic process Source: Ensembl
    18. neutrophil chemotaxis Source: Ensembl
    19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    20. positive regulation of chemokine biosynthetic process Source: Ensembl
    21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    24. positive regulation of interleukin-12 production Source: Ensembl
    25. positive regulation of interleukin-1 beta secretion Source: Ensembl
    26. positive regulation of interleukin-23 production Source: Ensembl
    27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    29. positive regulation of killing of cells of other organism Source: Ensembl
    30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    31. positive regulation of MHC class II biosynthetic process Source: Ensembl
    32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    33. positive regulation of osteoclast differentiation Source: Ensembl
    34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    36. positive regulation of T cell proliferation Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    39. positive regulation of tumor necrosis factor production Source: Ensembl
    40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    41. positive regulation of vitamin D biosynthetic process Source: Ensembl
    42. protein import into nucleus, translocation Source: Ensembl
    43. regulation of insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    CytokineUniRule annotation

    Keywords - Biological processi

    Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gammaUniRule annotation
    Short name:
    IFN-gammaUniRule annotation
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    Secreted UniRule annotation

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3GGX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II (or gamma) interferon family.UniRule annotation

    Phylogenomic databases

    KOiK04687.
    OMAiKEYFNAS.
    PhylomeDBiD3GGX1.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3GGX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD    50
    GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL 100
    YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS 150
    FKRKRSQSQR RCNC 164
    Length:164
    Mass (Da):18,953
    Last modified:March 23, 2010 - v1
    Checksum:i18D9B0BCA415B600
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ788637 mRNA. Translation: ACY72343.1.
    RefSeqiNP_990480.1. NM_205149.1.
    UniGeneiGga.916.

    Genome annotation databases

    GeneIDi396054.
    KEGGigga:396054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ788637 mRNA. Translation: ACY72343.1 .
    RefSeqi NP_990480.1. NM_205149.1.
    UniGenei Gga.916.

    3D structure databases

    ProteinModelPortali D3GGX1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396054.
    KEGGi gga:396054.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    KOi K04687.
    OMAi KEYFNAS.
    PhylomeDBi D3GGX1.

    Miscellaneous databases

    NextBioi 20816114.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of interferon gamma of China Lushi chicken."
      Zhang X., Zhang C., Li Y., Cheng X., Wu T.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Periphery blood lymphocytesImported.

    Entry informationi

    Entry nameiD3GGX1_CHICK
    AccessioniPrimary (citable) accession number: D3GGX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)