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D3GGX1

- D3GGX1_CHICK

UniProt

D3GGX1 - D3GGX1_CHICK

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Protein

Interferon gamma

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.UniRule annotation

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: Ensembl
  13. negative regulation of growth of symbiont in host Source: Ensembl
  14. negative regulation of interleukin-17 production Source: Ensembl
  15. negative regulation of myelination Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. neutrophil apoptotic process Source: Ensembl
  18. neutrophil chemotaxis Source: Ensembl
  19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  20. positive regulation of chemokine biosynthetic process Source: Ensembl
  21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  24. positive regulation of interleukin-12 production Source: Ensembl
  25. positive regulation of interleukin-1 beta secretion Source: Ensembl
  26. positive regulation of interleukin-23 production Source: Ensembl
  27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  29. positive regulation of killing of cells of other organism Source: Ensembl
  30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  31. positive regulation of MHC class II biosynthetic process Source: Ensembl
  32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  33. positive regulation of osteoclast differentiation Source: Ensembl
  34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  36. positive regulation of T cell proliferation Source: Ensembl
  37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  39. positive regulation of tumor necrosis factor production Source: Ensembl
  40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  41. positive regulation of vitamin D biosynthetic process Source: Ensembl
  42. protein import into nucleus, translocation Source: Ensembl
  43. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gammaUniRule annotation
Short name:
IFN-gammaUniRule annotation
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Secreted UniRule annotation

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3GGX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II (or gamma) interferon family.UniRule annotation

Phylogenomic databases

KOiK04687.
OMAiKEYFNAS.
PhylomeDBiD3GGX1.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

D3GGX1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD
60 70 80 90 100
GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL
110 120 130 140 150
YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS
160
FKRKRSQSQR RCNC
Length:164
Mass (Da):18,953
Last modified:March 23, 2010 - v1
Checksum:i18D9B0BCA415B600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ788637 mRNA. Translation: ACY72343.1.
RefSeqiNP_990480.1. NM_205149.1.
UniGeneiGga.916.

Genome annotation databases

GeneIDi396054.
KEGGigga:396054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ788637 mRNA. Translation: ACY72343.1 .
RefSeqi NP_990480.1. NM_205149.1.
UniGenei Gga.916.

3D structure databases

ProteinModelPortali D3GGX1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396054.
KEGGi gga:396054.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

KOi K04687.
OMAi KEYFNAS.
PhylomeDBi D3GGX1.

Miscellaneous databases

NextBioi 20816114.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of interferon gamma of China Lushi chicken."
    Zhang X., Zhang C., Li Y., Cheng X., Wu T.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Periphery blood lymphocytesImported.

Entry informationi

Entry nameiD3GGX1_CHICK
AccessioniPrimary (citable) accession number: D3GGX1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)