SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3GGX1

- D3GGX1_CHICK

UniProt

D3GGX1 - D3GGX1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interferon gamma

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity.UniRule annotation

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: Ensembl
  13. negative regulation of growth of symbiont in host Source: Ensembl
  14. negative regulation of interleukin-17 production Source: Ensembl
  15. negative regulation of myelination Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. neutrophil apoptotic process Source: Ensembl
  18. neutrophil chemotaxis Source: Ensembl
  19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  20. positive regulation of chemokine biosynthetic process Source: Ensembl
  21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  24. positive regulation of interleukin-12 production Source: Ensembl
  25. positive regulation of interleukin-1 beta secretion Source: Ensembl
  26. positive regulation of interleukin-23 production Source: Ensembl
  27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  29. positive regulation of killing of cells of other organism Source: Ensembl
  30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  31. positive regulation of MHC class II biosynthetic process Source: Ensembl
  32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  33. positive regulation of osteoclast differentiation Source: Ensembl
  34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  36. positive regulation of T cell proliferation Source: Ensembl
  37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  39. positive regulation of tumor necrosis factor production Source: Ensembl
  40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  41. positive regulation of vitamin D biosynthetic process Source: Ensembl
  42. protein import into nucleus, translocation Source: Ensembl
  43. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gammaUniRule annotation
Short name:
IFN-gammaUniRule annotation
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Secreted By similarity UniRule annotation

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3GGX1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK04687.
OMAiKEYFNAS.
PhylomeDBiD3GGX1.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

D3GGX1-1 [UniParc]FASTAAdd to Basket

« Hide

MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD    50
GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL 100
YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS 150
FKRKRSQSQR RCNC 164
Length:164
Mass (Da):18,953
Last modified:March 23, 2010 - v1
Checksum:i18D9B0BCA415B600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ788637 mRNA. Translation: ACY72343.1.
RefSeqiNP_990480.1. NM_205149.1.
UniGeneiGga.916.

Genome annotation databases

GeneIDi396054.
KEGGigga:396054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ788637 mRNA. Translation: ACY72343.1 .
RefSeqi NP_990480.1. NM_205149.1.
UniGenei Gga.916.

3D structure databases

ProteinModelPortali D3GGX1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396054.
KEGGi gga:396054.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

KOi K04687.
OMAi KEYFNAS.
PhylomeDBi D3GGX1.

Miscellaneous databases

NextBioi 20816114.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of interferon gamma of China Lushi chicken."
    Zhang X., Zhang C., Li Y., Cheng X., Wu T.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Periphery blood lymphocytesImported.

Entry informationi

Entry nameiD3GGX1_CHICK
AccessioniPrimary (citable) accession number: D3GGX1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi