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D3FSP1

- D3FSP1_BACPE

UniProt

D3FSP1 - D3FSP1_BACPE

Protein

Alanine racemase

Gene

alr

Organism
Bacillus pseudofirmus (strain OF4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Active sitei269 – 2691Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBPSE398511:GJI9-406-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:BpOF4_09770Imported
    OrganismiBacillus pseudofirmus (strain OF4)Imported
    Taxonomic identifieri398511 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001544: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3FSP1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3FSP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTSSFRNTY AQISLQALKE NAASFKASLQ SPACRLMAVV KGDGYGHGAV    50
    AAASSALNGG ADYLGVAILD EAIELRDAGV EAPILVLGYT SPHALREAIS 100
    RNITLTVFST DVRDALLEVA SEAESPIKVH IKTETGMGRV GVQTKEELLD 150
    VMTPLYHHNN IEVEGIFTHF AEADNLQSTY TDEQFARFLS FIEAIEKDDM 200
    HVPIKHCCNS AGTLFHKDKH LDMVRVGISL YGLRPDVSLE FPIELTQAMR 250
    LFSSIVSLRK LPEGSSISYG RTHKLSSEKV VATMPIGYAD GLSRALSNKG 300
    FVTLHGQKAP ILGRVCMDQT MIDVTDIPDA ALGDHVEFPI DEMAELTGTI 350
    NYEIVCAVSK RVPRYYEEN 369
    Length:369
    Mass (Da):40,323
    Last modified:March 23, 2010 - v1
    Checksum:i6AB6A9FCF9D85728
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001878 Genomic DNA. Translation: ADC50009.1.
    RefSeqiWP_012957375.1. NC_013791.2.
    YP_003426901.1. NC_013791.2.

    Genome annotation databases

    EnsemblBacteriaiADC50009; ADC50009; BpOF4_09770.
    GeneIDi8766985.
    KEGGibpf:BpOF4_09770.
    PATRICi31946432. VBIBacPse80461_1905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001878 Genomic DNA. Translation: ADC50009.1 .
    RefSeqi WP_012957375.1. NC_013791.2.
    YP_003426901.1. NC_013791.2.

    3D structure databases

    ProteinModelPortali D3FSP1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC50009 ; ADC50009 ; BpOF4_09770 .
    GeneIDi 8766985.
    KEGGi bpf:BpOF4_09770.
    PATRICi 31946432. VBIBacPse80461_1905.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci BPSE398511:GJI9-406-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4."
      Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G.
      , Xue Y., Ma Y., Hu F.Z., Krulwich T.A.
      Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OF4Imported.

    Entry informationi

    Entry nameiD3FSP1_BACPE
    AccessioniPrimary (citable) accession number: D3FSP1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3