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Protein

Alanine racemase

Gene

alr

Organism
Bacillus pseudofirmus (strain OF4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Active sitei269 – 2691Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBPSE398511:GJI9-406-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BpOF4_09770Imported
OrganismiBacillus pseudofirmus (strain OF4)Imported
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_09770.

Structurei

3D structure databases

ProteinModelPortaliD3FSP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 367120Ala_racemase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FSP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSSFRNTY AQISLQALKE NAASFKASLQ SPACRLMAVV KGDGYGHGAV
60 70 80 90 100
AAASSALNGG ADYLGVAILD EAIELRDAGV EAPILVLGYT SPHALREAIS
110 120 130 140 150
RNITLTVFST DVRDALLEVA SEAESPIKVH IKTETGMGRV GVQTKEELLD
160 170 180 190 200
VMTPLYHHNN IEVEGIFTHF AEADNLQSTY TDEQFARFLS FIEAIEKDDM
210 220 230 240 250
HVPIKHCCNS AGTLFHKDKH LDMVRVGISL YGLRPDVSLE FPIELTQAMR
260 270 280 290 300
LFSSIVSLRK LPEGSSISYG RTHKLSSEKV VATMPIGYAD GLSRALSNKG
310 320 330 340 350
FVTLHGQKAP ILGRVCMDQT MIDVTDIPDA ALGDHVEFPI DEMAELTGTI
360
NYEIVCAVSK RVPRYYEEN
Length:369
Mass (Da):40,323
Last modified:March 23, 2010 - v1
Checksum:i6AB6A9FCF9D85728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001878 Genomic DNA. Translation: ADC50009.1.
RefSeqiWP_012957375.1. NC_013791.2.

Genome annotation databases

EnsemblBacteriaiADC50009; ADC50009; BpOF4_09770.
KEGGibpf:BpOF4_09770.
PATRICi31946432. VBIBacPse80461_1905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001878 Genomic DNA. Translation: ADC50009.1.
RefSeqiWP_012957375.1. NC_013791.2.

3D structure databases

ProteinModelPortaliD3FSP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398511.BpOF4_09770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC50009; ADC50009; BpOF4_09770.
KEGGibpf:BpOF4_09770.
PATRICi31946432. VBIBacPse80461_1905.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiPOG091H022F.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBPSE398511:GJI9-406-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3FSP1_BACPE
AccessioniPrimary (citable) accession number: D3FSP1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.