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Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma gallisepticum (strain F)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi472MagnesiumBy similarity1
Active sitei476Sequence analysis1
Metal bindingi542MagnesiumBy similarity1
Active sitei545By similarity1
Metal bindingi545MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:MGF_2505
OrganismiMycoplasma gallisepticum (strain F)
Taxonomic identifieri708616 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004166061 – 655Ribonuclease 3Add BLAST655

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

SMRiD3FI09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini432 – 556RNase IIIAdd BLAST125
Domaini582 – 649DRBMAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400UnknownAdd BLAST400
Regioni401 – 655RNase 3Add BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 380Asn-richAdd BLAST289

Sequence similaritiesi

Belongs to the ribonuclease III family.Curated

Phylogenomic databases

eggNOGiENOG4107SU0 Bacteria
COG0571 LUCA
KOiK03685
OMAiKSRFPSM

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3FI09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLEKNTKK KIKKPNNFKK NNKDKTEELK DKPTPRMFKM TPKSSKFLHQ
60 70 80 90 100
LGVTGRKHTE KPVPLNDPDY EKKIREIQAK EAKKIRSDEV VNNNSKKQNN
110 120 130 140 150
NKQAKKKANK NKKQKGNNNN FQNNKKPENW KQKPAANNQV KAIPNSEKST
160 170 180 190 200
AKTAINLIIK RTFETLKQNN LIAPNLKQNP NKKDKPQQPN VAAKNNNQKE
210 220 230 240 250
VKKPYNNFVN NQKNHNKNNA GNKGDNKQPT KPLNQSKLSK STIVELPFTP
260 270 280 290 300
NFTSNQPKPT QKEDSKKVKA KKAENSQPQE SNKQVKKLEV KTNQQKQDQT
310 320 330 340 350
KKKQPKENKN QQIKAVNLNN NQQKTNNNNQ KNSVDKSEND NNKKKSEANQ
360 370 380 390 400
KQENLNPNNN NKKKEDSKNE SNNIPLINKN ISDQQIVKIS NYIKDNYPVI
410 420 430 440 450
YADLKEKNRL GFNSNLDDDK LIVYANYEAK DLELLLKKFK VVTNNIGLYE
460 470 480 490 500
EALTHNSYAN EMHLKYNYQR LEFLGDAIIN KIVAEYLFNH SDSSEGEMTK
510 520 530 540 550
DRIKIIQSNT LIKAATQLEL INYIRVGEGL KIAPLSPKIL EDIFEAFIGA
560 570 580 590 600
MYLDQGEYAV RKILNDTIIG YYQKGQLTEN TDYKSIFQEI IHSTGLNMKI
610 620 630 640 650
HYERTYDRQK NLHTVSLYAG GIMYGEGKDS STHKAEIKAA KEAISKFRGL

LKLEK
Length:655
Mass (Da):75,387
Last modified:March 23, 2010 - v1
Checksum:iBABBEDB7BAF8E4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001873 Genomic DNA Translation: ADC31272.1
RefSeqiWP_011113742.1, NC_017503.1

Genome annotation databases

EnsemblBacteriaiADC31272; ADC31272; MGF_2505
GeneIDi1089756
KEGGimgf:MGF_2505
PATRICifig|708616.3.peg.339

Entry informationi

Entry nameiRNC_MYCGF
AccessioniPrimary (citable) accession number: D3FI09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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