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D3FHR8

- D3FHR8_MYCGH

UniProt

D3FHR8 - D3FHR8_MYCGH

Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Mycoplasma gallisepticum (strain R(high / passage 156))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGAL710128:GLH7-817-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:gyrAUniRule annotationImported
    Ordered Locus Names:MGAH_0612Imported
    OrganismiMycoplasma gallisepticum (strain R(high / passage 156))Imported
    Taxonomic identifieri710128 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001813: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiD3FHR8.

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3FHR8.
    SMRiD3FHR8. Positions 40-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076278.
    KOiK02469.
    OMAiPRYTECK.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3FHR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPNDKNNIK ELLNKTVVKE ASITKELETS FMEYAMSVIV SRALPESRDG    50
    LKPVHRRVLY GAYTSGLTHD KPYRKSAQIV GHVMGKYHPH SDSAIYETMV 100
    RMAQPFSLRY MLIDGHGNFG SIDGDSAAAM RYTEARLSKI SAEMLRNIDK 150
    DTVDFVDNYD ASEQEPIVLP SLFPNLLANG SSGIAVGMAT NIPPHNLSEL 200
    IGGIKHLLVN ENATIEELKE FIKGPDFPTA AEILGETGIN EYFNTGRGSV 250
    SVRAKSEIEE LANNKSNIVI TQIPYMVNKA NLINKIAELV KTEQIQGIAD 300
    LRDESNREGI RIVIETKRDV IPEVLLNQLY KSTQLQTNFS VAMLALVNNQ 350
    PKVLNLKEAL QIYIDHQFDI LLRKTNFELK KAKASAHIVE GLVIATNNID 400
    DVIETIKNAK DNEDAKNTLM TKYELSDLQA KAILDMRLRS LSGLERENLQ 450
    KELAKLKELI KDLEEILQNK ERRIKIISDQ LDEIDHKFGD ERRTKICYGL 500
    NSTIDNEQLI PVETVVITRS SKGYLKRIPI SAYKVQHRGG VGVKGMNTYE 550
    DDDVESLIVC STHSDLLFFT NYGKVYRIRA HQVPLGSRIS KGIPAINLIS 600
    IEKDEKLMSL LSINDYDSGY FFFSTKKGLV KRVKASEFSR IQNNGKIAIK 650
    LTENDSLFKV IKTAGDEEIY IGVSSGLLVR FKEDVVRSMG RTAQGVIGVK 700
    FKNPNDEVIG LSSSHEGSLL LAVCEKGVGK MTDREEYRMT NRGSKGVITI 750
    KVTPKTGNII NTQLVNGNEE LLMISSTGKI VRVPLAEVSE QGRNTSGVKL 800
    ISLNEKETLQ SVAIFDVEQD DSQQVGSDNP DTELSSDDSN QDQDKE 846
    Length:846
    Mass (Da):94,333
    Last modified:March 23, 2010 - v1
    Checksum:iA5A16FEAAA5FB683
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30944.1.
    RefSeqiWP_011113986.1. NC_017502.1.
    YP_005880287.1. NC_017502.1.

    Genome annotation databases

    EnsemblBacteriaiADC30944; ADC30944; MGAH_0612.
    GeneIDi12395782.
    KEGGimgh:MGAH_0612.
    PATRICi36816743. VBIMycGal149415_0821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30944.1 .
    RefSeqi WP_011113986.1. NC_017502.1.
    YP_005880287.1. NC_017502.1.

    3D structure databases

    ProteinModelPortali D3FHR8.
    SMRi D3FHR8. Positions 40-497.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D3FHR8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC30944 ; ADC30944 ; MGAH_0612 .
    GeneIDi 12395782.
    KEGGi mgh:MGAH_0612.
    PATRICi 36816743. VBIMycGal149415_0821.

    Phylogenomic databases

    HOGENOMi HOG000076278.
    KOi K02469.
    OMAi PRYTECK.

    Enzyme and pathway databases

    BioCyci MGAL710128:GLH7-817-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum."
      Szczepanek S.M., Tulman E.R., Gorton T.S., Liao X., Lu Z., Zinski J., Aziz F., Frasca S. Jr., Kutish G.F., Geary S.J.
      Infect. Immun. 78:1760-1771(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R(high / passage 156)Imported.

    Entry informationi

    Entry nameiD3FHR8_MYCGH
    AccessioniPrimary (citable) accession number: D3FHR8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3