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D3FHK6

- D3FHK6_MYCGH

UniProt

D3FHK6 - D3FHK6_MYCGH

Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma gallisepticum (strain R(high / passage 156))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorUniRule annotation
    Metal bindingi150 – 1501ZincUniRule annotation
    Metal bindingi153 – 1531ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation
    Metal bindingi191 – 1911ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268ATPUniRule annotation
    Nucleotide bindingi93 – 964ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMGAL710128:GLH7-749-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:MGAH_0502Imported
    OrganismiMycoplasma gallisepticum (strain R(high / passage 156))Imported
    Taxonomic identifieri710128 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001813: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3FHK6.
    SMRiD3FHK6. Positions 12-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDHISEST.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3FHK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKNAMTTT NGWIEAICGP MFAGKTDELI RKIKRYEYAD VKSLVFSPAT    50
    DTRSAQEIIN SRDGRRIGSI KIKKAFEIYD YVLLHKPQLV GIDEVQFFDD 100
    SIVEVIQTLA DNQINVIVAG LDRDFRGEPF GPIPKILGIA ESVIRLTAIC 150
    SECGAEASRS QRLIDNQPAD YNCETILIGD TESYAPRCRH HHKVPNRPIN 200
    DQTKNFKRAL KNNFDKIVEQ SSKD 224
    Length:224
    Mass (Da):25,259
    Last modified:March 23, 2010 - v1
    Checksum:i8674C04BE5741FCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30882.1.
    RefSeqiYP_005880225.1. NC_017502.1.

    Genome annotation databases

    EnsemblBacteriaiADC30882; ADC30882; MGAH_0502.
    GeneIDi12395714.
    KEGGimgh:MGAH_0502.
    PATRICi36816597. VBIMycGal149415_0749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30882.1 .
    RefSeqi YP_005880225.1. NC_017502.1.

    3D structure databases

    ProteinModelPortali D3FHK6.
    SMRi D3FHK6. Positions 12-212.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC30882 ; ADC30882 ; MGAH_0502 .
    GeneIDi 12395714.
    KEGGi mgh:MGAH_0502.
    PATRICi 36816597. VBIMycGal149415_0749.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DHISEST.

    Enzyme and pathway databases

    BioCyci MGAL710128:GLH7-749-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum."
      Szczepanek S.M., Tulman E.R., Gorton T.S., Liao X., Lu Z., Zinski J., Aziz F., Frasca S. Jr., Kutish G.F., Geary S.J.
      Infect. Immun. 78:1760-1771(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R(high / passage 156)Imported.

    Entry informationi

    Entry nameiD3FHK6_MYCGH
    AccessioniPrimary (citable) accession number: D3FHK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3