Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3FH24

- RNC_MYCGH

UniProt

D3FH24 - RNC_MYCGH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma gallisepticum (strain R(high / passage 156))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi472 – 4721MagnesiumBy similarity
Active sitei476 – 4761Sequence Analysis
Metal bindingi542 – 5421MagnesiumBy similarity
Active sitei545 – 5451By similarity
Metal bindingi545 – 5451MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-EC
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-KW
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciMGAL710128:GLH7-564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:MGAH_0180
OrganismiMycoplasma gallisepticum (strain R(high / passage 156))
Taxonomic identifieri710128 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001813: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Ribonuclease 3PRO_0000416607Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini432 – 556125RNase IIIAdd
BLAST
Domaini582 – 64968DRBMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 400400UnknownAdd
BLAST
Regioni401 – 655255RNase 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 380289Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.Curated

Phylogenomic databases

KOiK03685.
OMAiTIVELPF.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FH24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLEKNTKK KIKKPNNFKK NNKDKTEELK DKPTPRMFKM TPKSSKFLHQ
60 70 80 90 100
LGVTGRKHTE KPVPLNDPDY EKKIREIQAK EAKKIRSDEV VNNNSKKQNN
110 120 130 140 150
NKQAKKKANK NKKQKGNNNN FQNNKKPENW KQKPAANNQV KAIPNSEKST
160 170 180 190 200
AKTAINLIIK RTFETLKQNN LIAPNLKQNP NKKDKPQQPN VAAKNNNQKE
210 220 230 240 250
VKKPYNNFVN NQKNHNKNNA GNKGDNKQPT KPLNQSKLSK STIVELPFTP
260 270 280 290 300
NFTSNQPKPT QKEDSKKVKA KKAENSQPQE SNKQVKKLEV KTNQQKQDQT
310 320 330 340 350
KKKQPKENKN QQIKAVNLNN NQQKTNNNNQ KNSVDKSEND NNKKKSEANQ
360 370 380 390 400
KQENLNPNNN NKKKEDSKNE SNNIPLINKN ISDQQIVKIS NYIKDNYPVI
410 420 430 440 450
YADLKEKNRL GFNSNLDDDK LIVYANYEAK DLELLLKKFK VVTNNIGLYE
460 470 480 490 500
EALTHNSYAN EMHLKYNYQR LEFLGDAIIN KIVAEYLFNH SDSSEGEMTK
510 520 530 540 550
DRIKIIQSNT LIKAATQLEL INYIRVGEGL KIAPLSPKIL EDIFEAFIGA
560 570 580 590 600
MYLDQGEYAV RKILNDTIIG YYQKGQLTEN TDYKSIFQEI IHSTGLNMKI
610 620 630 640 650
HYERTYDRQK NLHTVSLYAG GIMYGEGKDS STHKAEIKAA KEAISKFRGL

LKLEK
Length:655
Mass (Da):75,387
Last modified:March 23, 2010 - v1
Checksum:iBABBEDB7BAF8E4BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001872 Genomic DNA. Translation: ADC30700.1.
RefSeqiWP_011113742.1. NC_017502.1.
YP_005880043.1. NC_017502.1.

Genome annotation databases

EnsemblBacteriaiADC30700; ADC30700; MGAH_0180.
GeneIDi12395526.
KEGGimgh:MGAH_0180.
PATRICi36816211. VBIMycGal149415_0559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001872 Genomic DNA. Translation: ADC30700.1 .
RefSeqi WP_011113742.1. NC_017502.1.
YP_005880043.1. NC_017502.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC30700 ; ADC30700 ; MGAH_0180 .
GeneIDi 12395526.
KEGGi mgh:MGAH_0180.
PATRICi 36816211. VBIMycGal149415_0559.

Phylogenomic databases

KOi K03685.
OMAi TIVELPF.

Enzyme and pathway databases

BioCyci MGAL710128:GLH7-564-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum."
    Szczepanek S.M., Tulman E.R., Gorton T.S., Liao X., Lu Z., Zinski J., Aziz F., Frasca S. Jr., Kutish G.F., Geary S.J.
    Infect. Immun. 78:1760-1771(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(high / passage 156).

Entry informationi

Entry nameiRNC_MYCGH
AccessioniPrimary (citable) accession number: D3FH24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: March 23, 2010
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3