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D3FH24

- RNC_MYCGH

UniProt

D3FH24 - RNC_MYCGH

Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma gallisepticum (strain R(high / passage 156))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.

    Cofactori

    Mg2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi472 – 4721MagnesiumBy similarity
    Active sitei476 – 4761Sequence Analysis
    Metal bindingi542 – 5421MagnesiumBy similarity
    Active sitei545 – 5451By similarity
    Metal bindingi545 – 5451MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-EC
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-KW
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciMGAL710128:GLH7-564-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3 (EC:3.1.26.3)
    Alternative name(s):
    Ribonuclease III
    Short name:
    RNase III
    Gene namesi
    Name:rnc
    Ordered Locus Names:MGAH_0180
    OrganismiMycoplasma gallisepticum (strain R(high / passage 156))
    Taxonomic identifieri710128 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001813: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 655655Ribonuclease 3PRO_0000416607Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini432 – 556125RNase IIIAdd
    BLAST
    Domaini582 – 64968DRBMAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 400400UnknownAdd
    BLAST
    Regioni401 – 655255RNase 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 380289Asn-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RNase III domain.Curated

    Phylogenomic databases

    KOiK03685.
    OMAiTIVELPF.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3FH24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLEKNTKK KIKKPNNFKK NNKDKTEELK DKPTPRMFKM TPKSSKFLHQ    50
    LGVTGRKHTE KPVPLNDPDY EKKIREIQAK EAKKIRSDEV VNNNSKKQNN 100
    NKQAKKKANK NKKQKGNNNN FQNNKKPENW KQKPAANNQV KAIPNSEKST 150
    AKTAINLIIK RTFETLKQNN LIAPNLKQNP NKKDKPQQPN VAAKNNNQKE 200
    VKKPYNNFVN NQKNHNKNNA GNKGDNKQPT KPLNQSKLSK STIVELPFTP 250
    NFTSNQPKPT QKEDSKKVKA KKAENSQPQE SNKQVKKLEV KTNQQKQDQT 300
    KKKQPKENKN QQIKAVNLNN NQQKTNNNNQ KNSVDKSEND NNKKKSEANQ 350
    KQENLNPNNN NKKKEDSKNE SNNIPLINKN ISDQQIVKIS NYIKDNYPVI 400
    YADLKEKNRL GFNSNLDDDK LIVYANYEAK DLELLLKKFK VVTNNIGLYE 450
    EALTHNSYAN EMHLKYNYQR LEFLGDAIIN KIVAEYLFNH SDSSEGEMTK 500
    DRIKIIQSNT LIKAATQLEL INYIRVGEGL KIAPLSPKIL EDIFEAFIGA 550
    MYLDQGEYAV RKILNDTIIG YYQKGQLTEN TDYKSIFQEI IHSTGLNMKI 600
    HYERTYDRQK NLHTVSLYAG GIMYGEGKDS STHKAEIKAA KEAISKFRGL 650
    LKLEK 655
    Length:655
    Mass (Da):75,387
    Last modified:March 23, 2010 - v1
    Checksum:iBABBEDB7BAF8E4BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30700.1.
    RefSeqiWP_011113742.1. NC_017502.1.
    YP_005880043.1. NC_017502.1.

    Genome annotation databases

    EnsemblBacteriaiADC30700; ADC30700; MGAH_0180.
    GeneIDi12395526.
    KEGGimgh:MGAH_0180.
    PATRICi36816211. VBIMycGal149415_0559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001872 Genomic DNA. Translation: ADC30700.1 .
    RefSeqi WP_011113742.1. NC_017502.1.
    YP_005880043.1. NC_017502.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC30700 ; ADC30700 ; MGAH_0180 .
    GeneIDi 12395526.
    KEGGi mgh:MGAH_0180.
    PATRICi 36816211. VBIMycGal149415_0559.

    Phylogenomic databases

    KOi K03685.
    OMAi TIVELPF.

    Enzyme and pathway databases

    BioCyci MGAL710128:GLH7-564-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum."
      Szczepanek S.M., Tulman E.R., Gorton T.S., Liao X., Lu Z., Zinski J., Aziz F., Frasca S. Jr., Kutish G.F., Geary S.J.
      Infect. Immun. 78:1760-1771(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R(high / passage 156).

    Entry informationi

    Entry nameiRNC_MYCGH
    AccessioniPrimary (citable) accession number: D3FH24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3