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D3FF93

- D3FF93_CONWI

UniProt

D3FF93 - D3FF93_CONWI

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei100 – 1001SubstrateUniRule annotation
Binding sitei107 – 1071NADUniRule annotation
Binding sitei114 – 1141NADUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Active sitei189 – 1891Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 197NADUniRule annotation
Nucleotide bindingi131 – 1333NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciCWOE469383:GH82-5321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cwoe_5280Imported
OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
Taxonomic identifieri469383 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
ProteomesiUP000008229: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3FF93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00024.
OMAiVNDQAWL.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FF93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDKQPVRVA VTGAAGQIGY ALLFRIASGA LLGPDQPVSL RLLEITPALK
60 70 80 90 100
AVEGVIMELD DCAFPLLHSV EATDDANVAF DGASVGLLVG ARPRSRGMER
110 120 130 140 150
ADLLEANGGI FKPQGQAINA HAADDIKVLV VGNPANTNAL IAASNAPDVP
160 170 180 190 200
KDRFHAMTRL DHNRAIAQLS KKTGAAVKDI TNVTIWGNHS ATQYPDIFHA
210 220 230 240 250
KVNGQNAAEL VNDQAWLEND FIPTVQKRGA AIIDARGASS AASAANAAID
260 270 280 290 300
HVHDWVLGTP AGDWVSMSVP SDGSYGVPEG IISSFPCTTK PGGEYEIVQG
310 320 330
LEIDAFSRAR IDASANELVE ERAAIRQLGL I
Length:331
Mass (Da):34,807
Last modified:March 23, 2010 - v1
Checksum:iD5942AFCCDCCE33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001854 Genomic DNA. Translation: ADB53686.1.
RefSeqiYP_003397061.1. NC_013739.1.

Genome annotation databases

EnsemblBacteriaiADB53686; ADB53686; Cwoe_5280.
GeneIDi8735749.
KEGGicwo:Cwoe_5280.
PATRICi32052633. VBIConWoe21639_5302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001854 Genomic DNA. Translation: ADB53686.1 .
RefSeqi YP_003397061.1. NC_013739.1.

3D structure databases

ProteinModelPortali D3FF93.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB53686 ; ADB53686 ; Cwoe_5280 .
GeneIDi 8735749.
KEGGi cwo:Cwoe_5280.
PATRICi 32052633. VBIConWoe21639_5302.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00024.
OMAi VNDQAWL.

Enzyme and pathway databases

BioCyci CWOE469383:GH82-5321-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577Imported.

Entry informationi

Entry nameiD3FF93_CONWI
AccessioniPrimary (citable) accession number: D3FF93
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3