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D3FF93

- D3FF93_CONWI

UniProt

D3FF93 - D3FF93_CONWI

Protein

Malate dehydrogenase

Gene

mdh

Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei189 – 1891Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 197NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCWOE469383:GH82-5321-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Cwoe_5280Imported
    OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
    Taxonomic identifieri469383 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
    ProteomesiUP000008229: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3FF93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiVNDQAWL.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3FF93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDKQPVRVA VTGAAGQIGY ALLFRIASGA LLGPDQPVSL RLLEITPALK    50
    AVEGVIMELD DCAFPLLHSV EATDDANVAF DGASVGLLVG ARPRSRGMER 100
    ADLLEANGGI FKPQGQAINA HAADDIKVLV VGNPANTNAL IAASNAPDVP 150
    KDRFHAMTRL DHNRAIAQLS KKTGAAVKDI TNVTIWGNHS ATQYPDIFHA 200
    KVNGQNAAEL VNDQAWLEND FIPTVQKRGA AIIDARGASS AASAANAAID 250
    HVHDWVLGTP AGDWVSMSVP SDGSYGVPEG IISSFPCTTK PGGEYEIVQG 300
    LEIDAFSRAR IDASANELVE ERAAIRQLGL I 331
    Length:331
    Mass (Da):34,807
    Last modified:March 23, 2010 - v1
    Checksum:iD5942AFCCDCCE33A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001854 Genomic DNA. Translation: ADB53686.1.
    RefSeqiWP_012936737.1. NC_013739.1.
    YP_003397061.1. NC_013739.1.

    Genome annotation databases

    EnsemblBacteriaiADB53686; ADB53686; Cwoe_5280.
    GeneIDi8735749.
    KEGGicwo:Cwoe_5280.
    PATRICi32052633. VBIConWoe21639_5302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001854 Genomic DNA. Translation: ADB53686.1 .
    RefSeqi WP_012936737.1. NC_013739.1.
    YP_003397061.1. NC_013739.1.

    3D structure databases

    ProteinModelPortali D3FF93.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB53686 ; ADB53686 ; Cwoe_5280 .
    GeneIDi 8735749.
    KEGGi cwo:Cwoe_5280.
    PATRICi 32052633. VBIConWoe21639_5302.

    Phylogenomic databases

    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi VNDQAWL.

    Enzyme and pathway databases

    BioCyci CWOE469383:GH82-5321-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577Imported.

    Entry informationi

    Entry nameiD3FF93_CONWI
    AccessioniPrimary (citable) accession number: D3FF93
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3