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Protein

Malate dehydrogenase

Gene

mdh

Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei114NADUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 19NADUniRule annotation7
Nucleotide bindingi131 – 133NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cwoe_5280Imported
OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
Taxonomic identifieri469383 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaThermoleophiliaSolirubrobacteralesConexibacteraceaeConexibacter
Proteomesi
  • UP000008229 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiD3FF93.

Interactioni

Protein-protein interaction databases

STRINGi469383.Cwoe_5280.

Structurei

3D structure databases

ProteinModelPortaliD3FF93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 150Ldh_1_NInterPro annotationAdd BLAST144
Domaini158 – 322Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000220953.
KOiK00024.
OMAiQYPDAGQ.
OrthoDBiPOG091H03R4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FF93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKQPVRVA VTGAAGQIGY ALLFRIASGA LLGPDQPVSL RLLEITPALK
60 70 80 90 100
AVEGVIMELD DCAFPLLHSV EATDDANVAF DGASVGLLVG ARPRSRGMER
110 120 130 140 150
ADLLEANGGI FKPQGQAINA HAADDIKVLV VGNPANTNAL IAASNAPDVP
160 170 180 190 200
KDRFHAMTRL DHNRAIAQLS KKTGAAVKDI TNVTIWGNHS ATQYPDIFHA
210 220 230 240 250
KVNGQNAAEL VNDQAWLEND FIPTVQKRGA AIIDARGASS AASAANAAID
260 270 280 290 300
HVHDWVLGTP AGDWVSMSVP SDGSYGVPEG IISSFPCTTK PGGEYEIVQG
310 320 330
LEIDAFSRAR IDASANELVE ERAAIRQLGL I
Length:331
Mass (Da):34,807
Last modified:March 23, 2010 - v1
Checksum:iD5942AFCCDCCE33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001854 Genomic DNA. Translation: ADB53686.1.
RefSeqiWP_012936737.1. NC_013739.1.

Genome annotation databases

EnsemblBacteriaiADB53686; ADB53686; Cwoe_5280.
KEGGicwo:Cwoe_5280.
PATRICi32052633. VBIConWoe21639_5302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001854 Genomic DNA. Translation: ADB53686.1.
RefSeqiWP_012936737.1. NC_013739.1.

3D structure databases

ProteinModelPortaliD3FF93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469383.Cwoe_5280.

Proteomic databases

PRIDEiD3FF93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB53686; ADB53686; Cwoe_5280.
KEGGicwo:Cwoe_5280.
PATRICi32052633. VBIConWoe21639_5302.

Phylogenomic databases

eggNOGiENOG4105D9Z. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000220953.
KOiK00024.
OMAiQYPDAGQ.
OrthoDBiPOG091H03R4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3FF93_CONWI
AccessioniPrimary (citable) accession number: D3FF93
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.