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D3FC35

- D3FC35_CONWI

UniProt

D3FC35 - D3FC35_CONWI

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi364 – 3641Magnesium or manganese 1UniRule annotation
    Metal bindingi382 – 3821Magnesium or manganese 1UniRule annotation
    Metal bindingi382 – 3821Magnesium or manganese 2UniRule annotation
    Metal bindingi384 – 3841Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi180 – 23556ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCWOE469383:GH82-4956-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:Cwoe_4918Imported
    OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
    Taxonomic identifieri469383 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
    ProteomesiUP000008229: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3FC35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 411265ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000011593.
    KOiK01921.
    OMAiERICVNE.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3FC35-1 [UniParc]FASTAAdd to Basket

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    MPLPSGQTVG VVFGGPSVEH DVSIITAQQA MAVLSERHTV VPLYIGKDGR    50
    WWTGEELRDV SAFTQAPPRG ARAVELRLGA ADGPFVEPST SRLRGDRALA 100
    ISVVLNAIHG TGGEDGALLG ALELSGVPHA GRGVAAFAVG MDKHLAKTVL 150
    REAGIDVLPH RRIERGEWEH DRAAVLRSVA DEVPLPCVVK PATLGSSIGV 200
    ARCADPAEVE EALELAFELD RQAVVEPFAT GATELNCAVL GRPGGELRVS 250
    EVERPLGGEA GLTFEDKYLS SGGGKGGTGG GAKGGGAKAA GEGAAGGSKA 300
    AGGGGAGGAG GGAKGGDGDR AGGGMAAQGR VIPADIAPEL RERVRAEAAK 350
    AHRALRVAGV VRYDFFVLPD PDGGAERICV NEPNTVPGSF AFYLFEPEGL 400
    AFPDLLDELL AIGLAEAREE RLTTRSFASA LIDRHASAA 439
    Length:439
    Mass (Da):44,910
    Last modified:March 23, 2010 - v1
    Checksum:i8906822442480850
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001854 Genomic DNA. Translation: ADB53330.1.
    RefSeqiWP_012936381.1. NC_013739.1.
    YP_003396705.1. NC_013739.1.

    Genome annotation databases

    EnsemblBacteriaiADB53330; ADB53330; Cwoe_4918.
    GeneIDi8735384.
    KEGGicwo:Cwoe_4918.
    PATRICi32051919. VBIConWoe21639_4948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001854 Genomic DNA. Translation: ADB53330.1 .
    RefSeqi WP_012936381.1. NC_013739.1.
    YP_003396705.1. NC_013739.1.

    3D structure databases

    ProteinModelPortali D3FC35.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB53330 ; ADB53330 ; Cwoe_4918 .
    GeneIDi 8735384.
    KEGGi cwo:Cwoe_4918.
    PATRICi 32051919. VBIConWoe21639_4948.

    Phylogenomic databases

    HOGENOMi HOG000011593.
    KOi K01921.
    OMAi ERICVNE.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CWOE469383:GH82-4956-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577Imported.

    Entry informationi

    Entry nameiD3FC35_CONWI
    AccessioniPrimary (citable) accession number: D3FC35
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3