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D3FC35

- D3FC35_CONWI

UniProt

D3FC35 - D3FC35_CONWI

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi364 – 3641Magnesium or manganese 1UniRule annotation
Metal bindingi382 – 3821Magnesium or manganese 1UniRule annotation
Metal bindingi382 – 3821Magnesium or manganese 2UniRule annotation
Metal bindingi384 – 3841Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 23556ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCWOE469383:GH82-4956-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Cwoe_4918Imported
OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
Taxonomic identifieri469383 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
ProteomesiUP000008229: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3FC35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 411265ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.
OMAiERICVNE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FC35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLPSGQTVG VVFGGPSVEH DVSIITAQQA MAVLSERHTV VPLYIGKDGR
60 70 80 90 100
WWTGEELRDV SAFTQAPPRG ARAVELRLGA ADGPFVEPST SRLRGDRALA
110 120 130 140 150
ISVVLNAIHG TGGEDGALLG ALELSGVPHA GRGVAAFAVG MDKHLAKTVL
160 170 180 190 200
REAGIDVLPH RRIERGEWEH DRAAVLRSVA DEVPLPCVVK PATLGSSIGV
210 220 230 240 250
ARCADPAEVE EALELAFELD RQAVVEPFAT GATELNCAVL GRPGGELRVS
260 270 280 290 300
EVERPLGGEA GLTFEDKYLS SGGGKGGTGG GAKGGGAKAA GEGAAGGSKA
310 320 330 340 350
AGGGGAGGAG GGAKGGDGDR AGGGMAAQGR VIPADIAPEL RERVRAEAAK
360 370 380 390 400
AHRALRVAGV VRYDFFVLPD PDGGAERICV NEPNTVPGSF AFYLFEPEGL
410 420 430
AFPDLLDELL AIGLAEAREE RLTTRSFASA LIDRHASAA
Length:439
Mass (Da):44,910
Last modified:March 23, 2010 - v1
Checksum:i8906822442480850
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53330.1.
RefSeqiWP_012936381.1. NC_013739.1.
YP_003396705.1. NC_013739.1.

Genome annotation databases

EnsemblBacteriaiADB53330; ADB53330; Cwoe_4918.
GeneIDi8735384.
KEGGicwo:Cwoe_4918.
PATRICi32051919. VBIConWoe21639_4948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53330.1 .
RefSeqi WP_012936381.1. NC_013739.1.
YP_003396705.1. NC_013739.1.

3D structure databases

ProteinModelPortali D3FC35.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB53330 ; ADB53330 ; Cwoe_4918 .
GeneIDi 8735384.
KEGGi cwo:Cwoe_4918.
PATRICi 32051919. VBIConWoe21639_4948.

Phylogenomic databases

HOGENOMi HOG000011593.
KOi K01921.
OMAi ERICVNE.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CWOE469383:GH82-4956-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577Imported.

Entry informationi

Entry nameiD3FC35_CONWI
AccessioniPrimary (citable) accession number: D3FC35
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3