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D3FC35 (D3FC35_CONWI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Cwoe_4918 EMBL ADB53330.1
OrganismConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577) [Complete proteome] [HAMAP] EMBL ADB53330.1
Taxonomic identifier469383 [NCBI]
Taxonomic lineageBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain147 – 411265ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding180 – 23556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3641Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D3FC35 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: 8906822442480850

FASTA43944,910
        10         20         30         40         50         60 
MPLPSGQTVG VVFGGPSVEH DVSIITAQQA MAVLSERHTV VPLYIGKDGR WWTGEELRDV 

        70         80         90        100        110        120 
SAFTQAPPRG ARAVELRLGA ADGPFVEPST SRLRGDRALA ISVVLNAIHG TGGEDGALLG 

       130        140        150        160        170        180 
ALELSGVPHA GRGVAAFAVG MDKHLAKTVL REAGIDVLPH RRIERGEWEH DRAAVLRSVA 

       190        200        210        220        230        240 
DEVPLPCVVK PATLGSSIGV ARCADPAEVE EALELAFELD RQAVVEPFAT GATELNCAVL 

       250        260        270        280        290        300 
GRPGGELRVS EVERPLGGEA GLTFEDKYLS SGGGKGGTGG GAKGGGAKAA GEGAAGGSKA 

       310        320        330        340        350        360 
AGGGGAGGAG GGAKGGDGDR AGGGMAAQGR VIPADIAPEL RERVRAEAAK AHRALRVAGV 

       370        380        390        400        410        420 
VRYDFFVLPD PDGGAERICV NEPNTVPGSF AFYLFEPEGL AFPDLLDELL AIGLAEAREE 

       430 
RLTTRSFASA LIDRHASAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001854 Genomic DNA. Translation: ADB53330.1.
RefSeqYP_003396705.1. NC_013739.1.

3D structure databases

ProteinModelPortalD3FC35.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB53330; ADB53330; Cwoe_4918.
GeneID8735384.
KEGGcwo:Cwoe_4918.
PATRIC32051919. VBIConWoe21639_4948.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAERICVNE.

Enzyme and pathway databases

BioCycCWOE469383:GH82-4956-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3FC35_CONWI
AccessionPrimary (citable) accession number: D3FC35
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)