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D3FC35

- D3FC35_CONWI

UniProt

D3FC35 - D3FC35_CONWI

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Protein
D-alanine--D-alanine ligase
Gene
ddl, Cwoe_4918
Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi364 – 3641Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi382 – 3821Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi382 – 3821Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi384 – 3841Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 23556ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCWOE469383:GH82-4956-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Cwoe_4918Imported
OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
Taxonomic identifieri469383 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
ProteomesiUP000008229: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3FC35.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 411265ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.
OMAiERICVNE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FC35-1 [UniParc]FASTAAdd to Basket

« Hide

MPLPSGQTVG VVFGGPSVEH DVSIITAQQA MAVLSERHTV VPLYIGKDGR    50
WWTGEELRDV SAFTQAPPRG ARAVELRLGA ADGPFVEPST SRLRGDRALA 100
ISVVLNAIHG TGGEDGALLG ALELSGVPHA GRGVAAFAVG MDKHLAKTVL 150
REAGIDVLPH RRIERGEWEH DRAAVLRSVA DEVPLPCVVK PATLGSSIGV 200
ARCADPAEVE EALELAFELD RQAVVEPFAT GATELNCAVL GRPGGELRVS 250
EVERPLGGEA GLTFEDKYLS SGGGKGGTGG GAKGGGAKAA GEGAAGGSKA 300
AGGGGAGGAG GGAKGGDGDR AGGGMAAQGR VIPADIAPEL RERVRAEAAK 350
AHRALRVAGV VRYDFFVLPD PDGGAERICV NEPNTVPGSF AFYLFEPEGL 400
AFPDLLDELL AIGLAEAREE RLTTRSFASA LIDRHASAA 439
Length:439
Mass (Da):44,910
Last modified:March 23, 2010 - v1
Checksum:i8906822442480850
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53330.1.
RefSeqiWP_012936381.1. NC_013739.1.
YP_003396705.1. NC_013739.1.

Genome annotation databases

EnsemblBacteriaiADB53330; ADB53330; Cwoe_4918.
GeneIDi8735384.
KEGGicwo:Cwoe_4918.
PATRICi32051919. VBIConWoe21639_4948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53330.1 .
RefSeqi WP_012936381.1. NC_013739.1.
YP_003396705.1. NC_013739.1.

3D structure databases

ProteinModelPortali D3FC35.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB53330 ; ADB53330 ; Cwoe_4918 .
GeneIDi 8735384.
KEGGi cwo:Cwoe_4918.
PATRICi 32051919. VBIConWoe21639_4948.

Phylogenomic databases

HOGENOMi HOG000011593.
KOi K01921.
OMAi ERICVNE.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CWOE469383:GH82-4956-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577.

Entry informationi

Entry nameiD3FC35_CONWI
AccessioniPrimary (citable) accession number: D3FC35
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3