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D3FC34

- D3FC34_CONWI

UniProt

D3FC34 - D3FC34_CONWI

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Protein
D-alanine--D-alanine ligase
Gene
ddl, Cwoe_4917
Organism
Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi260 – 2601Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi272 – 2721Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi272 – 2721Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi274 – 2741Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi133 – 18856ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCWOE469383:GH82-4955-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Cwoe_4917Imported
OrganismiConexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)Imported
Taxonomic identifieri469383 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeSolirubrobacteralesConexibacteraceaeConexibacter
ProteomesiUP000008229: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3FC34.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 305207ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiFATRENK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3FC34-1 [UniParc]FASTAAdd to Basket

« Hide

MKALVAYGGR SLEREVSARS GQQAAKALRQ LGHAVELIDV GADFVDVVQR    50
AEPDFVFIAL HGVGGEDGTV QDLLEILQVP YTGSDALASA LCLDKHTFKS 100
VCELRGVPTP PWHSFTKQAF ADYGAGKTLD ALWQQFDGRA VVKPARQGSS 150
FGLSVVQERA QLGGAVLGAM SYDDRVLLER YVPGRELAVT VLGRSDAPEP 200
LPVVEIVMAS EEYYSFQAHY EIGQSEVRLA GLPDAVDAHV RAIAAEAYSA 250
AGCRDFARVD IRLEGDEPWV LEINTIPGLT ETGPTPLAAE HAGLTFAQLI 300
ERISARVVG 309
Length:309
Mass (Da):33,185
Last modified:March 23, 2010 - v1
Checksum:i4706E4513E4865D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53329.1.
RefSeqiWP_012936380.1. NC_013739.1.
YP_003396704.1. NC_013739.1.

Genome annotation databases

EnsemblBacteriaiADB53329; ADB53329; Cwoe_4917.
GeneIDi8735383.
KEGGicwo:Cwoe_4917.
PATRICi32051917. VBIConWoe21639_4947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001854 Genomic DNA. Translation: ADB53329.1 .
RefSeqi WP_012936380.1. NC_013739.1.
YP_003396704.1. NC_013739.1.

3D structure databases

ProteinModelPortali D3FC34.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB53329 ; ADB53329 ; Cwoe_4917 .
GeneIDi 8735383.
KEGGi cwo:Cwoe_4917.
PATRICi 32051917. VBIConWoe21639_4947.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi FATRENK.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CWOE469383:GH82-4955-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14684 / JCM 11494 / NBRC 100937 / ID131577.

Entry informationi

Entry nameiD3FC34_CONWI
AccessioniPrimary (citable) accession number: D3FC34
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3