ID   D3FBT8_CONWI            Unreviewed;       683 AA.
AC   D3FBT8;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Diguanylate cyclase and metal dependent phosphohydrolase {ECO:0000313|EMBL:ADB51353.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Cwoe_2934 {ECO:0000313|EMBL:ADB51353.1};
OS   Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC
OS   100937 / ID131577).
OC   Bacteria; Actinomycetota; Thermoleophilia; Solirubrobacterales;
OC   Conexibacteraceae; Conexibacter.
OX   NCBI_TaxID=469383 {ECO:0000313|EMBL:ADB51353.1, ECO:0000313|Proteomes:UP000008229};
RN   [1] {ECO:0000313|EMBL:ADB51353.1, ECO:0000313|Proteomes:UP000008229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577
RC   {ECO:0000313|Proteomes:UP000008229};
RX   PubMed=21304704;
RA   Pukall R., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA   Cheng J.-F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Mavromatis K., Ivanova N., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.-J., Jeffries C.D., Chain P.,
RA   Meincke L., Sims D., Brettin T., Detter J.C., Rohde M., Goeker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Kyrpides N.C., Klenk H.-P.,
RA   Hugenholtz P.;
RT   "Complete genome sequence of Conexibacter woesei type strain (ID131577).";
RL   Stand. Genomic Sci. 2:212-219(2010).
RN   [2] {ECO:0000313|Proteomes:UP000008229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577
RC   {ECO:0000313|Proteomes:UP000008229};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Mikhailova N., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA   Wu D., Pukall R., Steenblock K., Schneider S., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Conexibacter woesei DSM 14684.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001854; ADB51353.1; -; Genomic_DNA.
DR   RefSeq; WP_012934404.1; NC_013739.1.
DR   AlphaFoldDB; D3FBT8; -.
DR   STRING; 469383.Cwoe_2934; -.
DR   KEGG; cwo:Cwoe_2934; -.
DR   eggNOG; COG2199; Bacteria.
DR   eggNOG; COG3437; Bacteria.
DR   HOGENOM; CLU_000445_11_30_11; -.
DR   OrthoDB; 9802066at2; -.
DR   Proteomes; UP000008229; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   PANTHER; PTHR45228:SF4; LIPOPROTEIN-RELATED; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ADB51353.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008229};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        71..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          353..480
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          472..667
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   REGION          655..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  72970 MW;  ED3879F9C92A6F2C CRC64;
     MQLNISGAPL RRLLAVVTAV ALALLFAQAL TDFGGAWADV AIDDVVYFGL ELGGATACLV
     RAALVRDRRP AWICIGLAIL LYAAGDAFWG LQSARGAYPW PADVAYVAFY PLSLGGMALL
     LADGRDQVAA RLWVDGLIAG LAVGAVAVAF AYEPILEATS ASSTQTALHL AYPLTDLMMI
     ALVLTAFATQ AWRPGGVWVL LAIGALIFAV ADTLYAYQSA NGTFDDDSLV SALWPAALVT
     WGWAAWQPWR PRHVDYGFGR QTFALPTVFA ALAVALLLYG QFADVPTAAA LLATAALLLA
     TARAGRTFRE NMRLLRATRE EALTDGLTGL PNRRRLMHDL ERAVALCTAD ERLRRTLVFF
     DLDGFKGYND GFGHAAGDML LDRLAGRLAE VVVGRGRAYR LGGDEFCVLL DGALPADDPL
     ILAAVATLRE QGEGFRVGAS YGVVTIPCEA QSATHALQLA DQRMYAAKDA SRTSSRRQTC
     DVLLQVLRER EPDLHEHLHG VAALVVGVAR ELGLDAEQVD EVARAAELHD IGKIAIPDAI
     LHKPGPLDAD EWRLMREHTV VGDRILGAAP AMRPVARIVR SSHERWDGCG YPDGLAAEQI
     PLGARIVAVC DAYDAMTSER PYQRRLAHAS ALTELRRCAG SQFDPAVVAA FVESSPGGSH
     SIGTTRPGAR APGPSSSEEA ATP
//