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Protein

Homoserine O-acetyltransferase

Gene

metAA

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metAA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111Important for acyl-CoA specificityUniRule annotation1
Active sitei142UniRule annotation1
Active sitei142Acyl-thioester intermediateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Sitei192Important for substrate specificityUniRule annotation1
Active sitei235Proton acceptorUniRule annotation1
Active sitei237UniRule annotation1
Binding sitei249SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metAAUniRule annotation
Ordered Locus Names:GYMC10_5106Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002381 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi481743.GYMC10_5106.

Family & Domainsi

Sequence similaritiesi

Belongs to the MetA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CVG. Bacteria.
COG1897. LUCA.
HOGENOMiHOG000115049.
KOiK00651.
OMAiCWAAHAA.
OrthoDBiPOG091H02LI.

Family and domain databases

CDDicd03131. GATase1_HTS. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr. 1 hit.
InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
IPR033752. HTS_family.
PANTHERiPTHR20919. PTHR20919. 1 hit.
PTHR20919:SF1. PTHR20919:SF1. 1 hit.
PfamiView protein in Pfam
PF04204. HTS. 1 hit.
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

D3EEN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKIPDALP AKEVLAGENI FVMDESHAFH QDIRPLRIAI LNLMPTKETT
60 70 80 90 100
ETQLLRLIGN SPLQVDVVLL HPSSHVSKNT SAEHLKSFYK TFEEVKNRRF
110 120 130 140 150
DGMIITGAPV EQLEFEEVNY WDELTEIFEW TKTHVTSTLH ICWASQAGLY
160 170 180 190 200
YHYGVPKYSL EEKCFGVFPH TINEACTKLL RGFDEMFFVP HSRHTEVRRE
210 220 230 240 250
DITGVDDLVI LSESEEAGIY LVSSRDGKQI FATGHSEYDA DSLKWEYDRD
260 270 280 290 300
VAKGMDIALP RNYYPNDDPT RTPPSIWRAH ANLLFTNWLN YYVYQETPYD

IGPQI
Length:305
Mass (Da):35,219
Last modified:March 23, 2010 - v1
Checksum:i53771583F126F19B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX67318.1.
RefSeqiWP_015737127.1. NC_013406.1.

Genome annotation databases

EnsemblBacteriaiACX67318; ACX67318; GYMC10_5106.
KEGGigym:GYMC10_5106.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3EEN1_GEOS4
AccessioniPrimary (citable) accession number: D3EEN1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported