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Protein

Homoserine O-succinyltransferase

Gene

metA

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421UniRule annotation

GO - Molecular functioni

  1. homoserine O-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP481743:GH8K-5157-MONOMER.
UniPathwayiUPA00051; UER00075.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferaseUniRule annotation (EC:2.3.1.46UniRule annotation)
Alternative name(s):
Homoserine O-transsuccinylaseUniRule annotation
Gene namesi
Name:metAUniRule annotation
Ordered Locus Names:GYMC10_5106Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002381: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the HTS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.
OrthoDBiEOG61P6ST.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomiPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

D3EEN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKIPDALP AKEVLAGENI FVMDESHAFH QDIRPLRIAI LNLMPTKETT
60 70 80 90 100
ETQLLRLIGN SPLQVDVVLL HPSSHVSKNT SAEHLKSFYK TFEEVKNRRF
110 120 130 140 150
DGMIITGAPV EQLEFEEVNY WDELTEIFEW TKTHVTSTLH ICWASQAGLY
160 170 180 190 200
YHYGVPKYSL EEKCFGVFPH TINEACTKLL RGFDEMFFVP HSRHTEVRRE
210 220 230 240 250
DITGVDDLVI LSESEEAGIY LVSSRDGKQI FATGHSEYDA DSLKWEYDRD
260 270 280 290 300
VAKGMDIALP RNYYPNDDPT RTPPSIWRAH ANLLFTNWLN YYVYQETPYD

IGPQI
Length:305
Mass (Da):35,219
Last modified:March 23, 2010 - v1
Checksum:i53771583F126F19B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX67318.1.
RefSeqiYP_003245125.1. NC_013406.1.

Genome annotation databases

EnsemblBacteriaiACX67318; ACX67318; GYMC10_5106.
GeneIDi8519294.
KEGGigym:GYMC10_5106.
PATRICi32158739. VBIGeoSp56627_5077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX67318.1.
RefSeqiYP_003245125.1. NC_013406.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX67318; ACX67318; GYMC10_5106.
GeneIDi8519294.
KEGGigym:GYMC10_5106.
PATRICi32158739. VBIGeoSp56627_5077.

Phylogenomic databases

HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.
OrthoDBiEOG61P6ST.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00075.
BioCyciPSP481743:GH8K-5157-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomiPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Geobacillus sp. Y412MC10."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Brumm P., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC10Imported.

Entry informationi

Entry nameiD3EEN1_GEOS4
AccessioniPrimary (citable) accession number: D3EEN1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.