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Protein

Isocitrate dehydrogenase [NADP]

Gene

GYMC10_4927

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPSP481743:GH8K-4978-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:GYMC10_4927Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002381 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi481743.GYMC10_4927.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ECL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEKFALPT EGEKITIDNG TLQVPNNPVI PFIEGDGTGR DIWKASKRVL
60 70 80 90 100
DAAVEKAYNG SKKIAWYEVF AGEKAYNTYG EWLPNDTLEA IREYIVAIKG
110 120 130 140 150
PLTTPIGGGI RSLNVALRQE LDLYTCLRPV RYFNGVPSPV KRPELVDMVI
160 170 180 190 200
FRENTEDIYA GIEYKEGSDE VKKVIKFLQD EMGANKIRFP ETSGIGIKPV
210 220 230 240 250
SSEGSKRLVR AAVEYAIKHG RKSVTLVHKG NIMKFTEGAF KNWGYEVAEA
260 270 280 290 300
EFGDKVFTWA QYDIIKDKDG VDAANAAQKA AEEAGKIIVK DAIADIALQQ
310 320 330 340 350
VLTRPTDFDV IATLNLNGDY LSDALAAQVG GIGIAPGANI NYVTGHAIFE
360 370 380 390 400
ATHGTAPKYA DKDVVNPGSV ILSGVMLLEH LGWQEAADLI YKGMETSINN
410 420 430
KTVTYDFARL MEGATEVKCS EFADEIIKNL
Length:430
Mass (Da):47,194
Last modified:March 23, 2010 - v1
Checksum:iA76103219E4F013F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX67141.1.
RefSeqiWP_009595069.1. NC_013406.1.
YP_003244948.1. NC_013406.1.

Genome annotation databases

EnsemblBacteriaiACX67141; ACX67141; GYMC10_4927.
KEGGigym:GYMC10_4927.
PATRICi32158373. VBIGeoSp56627_4894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX67141.1.
RefSeqiWP_009595069.1. NC_013406.1.
YP_003244948.1. NC_013406.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi481743.GYMC10_4927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX67141; ACX67141; GYMC10_4927.
KEGGigym:GYMC10_4927.
PATRICi32158373. VBIGeoSp56627_4894.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciPSP481743:GH8K-4978-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Geobacillus sp. Y412MC10."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Brumm P., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC10Imported.

Entry informationi

Entry nameiD3ECL7_GEOS4
AccessioniPrimary (citable) accession number: D3ECL7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.