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D3ECL7

- D3ECL7_GEOS4

UniProt

D3ECL7 - D3ECL7_GEOS4

Protein

Isocitrate dehydrogenase [NADP]

Gene

GYMC10_4927

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciPSP481743:GH8K-4978-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:GYMC10_4927Imported
    OrganismiGeobacillus sp. (strain Y412MC10)Imported
    Taxonomic identifieri481743 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000002381: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiAITIFRE.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ECL7-1 [UniParc]FASTAAdd to Basket

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    MKLEKFALPT EGEKITIDNG TLQVPNNPVI PFIEGDGTGR DIWKASKRVL    50
    DAAVEKAYNG SKKIAWYEVF AGEKAYNTYG EWLPNDTLEA IREYIVAIKG 100
    PLTTPIGGGI RSLNVALRQE LDLYTCLRPV RYFNGVPSPV KRPELVDMVI 150
    FRENTEDIYA GIEYKEGSDE VKKVIKFLQD EMGANKIRFP ETSGIGIKPV 200
    SSEGSKRLVR AAVEYAIKHG RKSVTLVHKG NIMKFTEGAF KNWGYEVAEA 250
    EFGDKVFTWA QYDIIKDKDG VDAANAAQKA AEEAGKIIVK DAIADIALQQ 300
    VLTRPTDFDV IATLNLNGDY LSDALAAQVG GIGIAPGANI NYVTGHAIFE 350
    ATHGTAPKYA DKDVVNPGSV ILSGVMLLEH LGWQEAADLI YKGMETSINN 400
    KTVTYDFARL MEGATEVKCS EFADEIIKNL 430
    Length:430
    Mass (Da):47,194
    Last modified:March 23, 2010 - v1
    Checksum:iA76103219E4F013F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001793 Genomic DNA. Translation: ACX67141.1.
    RefSeqiYP_003244948.1. NC_013406.1.

    Genome annotation databases

    EnsemblBacteriaiACX67141; ACX67141; GYMC10_4927.
    GeneIDi8519115.
    KEGGigym:GYMC10_4927.
    PATRICi32158373. VBIGeoSp56627_4894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001793 Genomic DNA. Translation: ACX67141.1 .
    RefSeqi YP_003244948.1. NC_013406.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX67141 ; ACX67141 ; GYMC10_4927 .
    GeneIDi 8519115.
    KEGGi gym:GYMC10_4927.
    PATRICi 32158373. VBIGeoSp56627_4894.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi AITIFRE.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci PSP481743:GH8K-4978-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Geobacillus sp. Y412MC10."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Brumm P., Mead D.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y412MC10Imported.

    Entry informationi

    Entry nameiD3ECL7_GEOS4
    AccessioniPrimary (citable) accession number: D3ECL7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3