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Protein

Aspartokinase

Gene

GYMC10_4130

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (GYMC10_2089), Aspartokinase (GYMC10_4130)
  2. no protein annotated in this organism
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (GYMC10_2089), Aspartokinase (GYMC10_4130)
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (GYMC10_1550)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (GYMC10_2089), Aspartokinase (GYMC10_4130)
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (GYMC10_1550)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (GYMC10_1551)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPSP481743:G1GGE-4110-MONOMER
UniPathwayiUPA00034; UER00015
UPA00050; UER00461
UPA00051; UER00462

Names & Taxonomyi

Protein namesi
Recommended name:
AspartokinaseUniRule annotation (EC:2.7.2.4UniRule annotation)
Gene namesi
Ordered Locus Names:GYMC10_4130Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002381 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi481743.GYMC10_4130

Structurei

3D structure databases

ProteinModelPortaliD3E6N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 235AA_kinaseInterPro annotationAdd BLAST233
Domaini337 – 397ACT_7InterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the aspartokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFH Bacteria
COG0527 LUCA
HOGENOMiHOG000293093
KOiK00928
OMAiLMSCGEV
OrthoDBiPOG091H0223

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR005260 Asp_kin_monofn
IPR001341 Asp_kinase
IPR018042 Aspartate_kinase_CS
IPR027795 CASTOR_ACT_dom
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF13840 ACT_7, 1 hit
PIRSFiPIRSF000726 Asp_kin, 2 hits
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00656 asp_kin_monofn, 1 hit
TIGR00657 asp_kinases, 1 hit
PROSITEiView protein in PROSITE
PS00324 ASPARTOKINASE, 1 hit

Sequencei

Sequence statusi: Complete.

D3E6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILVQKFGG TSLSTPQART HVIGHIQREL ANHYQLVVVV SAMGRRGEPY
60 70 80 90 100
ATDTLLDWIG HNGNALPDRE RDLLLCCGEI ISASTLCSLL QHEGITATVL
110 120 130 140 150
TGAQAGFLTD DHFGNARIKD VKPERVLKEL ESHQVVIVTG FQGQTDSGDF
160 170 180 190 200
TTLGRGGSDT SATALGAALR AEMVDIYTDV NGILTADPRI VEDAKPLSYV
210 220 230 240 250
SYTEICNMAH QGAKVIHPRA VEIAMQSQIP VRVRSTFSDN EGTLVTQPEG
260 270 280 290 300
FRDIQSGIVD RFVTGVAYVS NITQISVECD RTEGLQLKVF KSMAEHSISV
310 320 330 340 350
DFINVTPTGV LYTVFDSDSE KAIEVLQSLD LKPKSLSGCA KVSVIGGGIN
360 370 380 390 400
GVPGIMAKIV ESLSEHDIPI LQSADSNTTI WVLVKKEDMA QALRALHHKF

ELHR
Length:404
Mass (Da):43,844
Last modified:March 23, 2010 - v1
Checksum:iB2648516E59CD0ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA Translation: ACX66358.1
RefSeqiWP_015736294.1, NC_013406.1

Genome annotation databases

EnsemblBacteriaiACX66358; ACX66358; GYMC10_4130
KEGGigym:GYMC10_4130

Similar proteinsi

Entry informationi

Entry nameiD3E6N5_GEOS4
AccessioniPrimary (citable) accession number: D3E6N5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health