ID D3E5B2_GEOS4 Unreviewed; 597 AA. AC D3E5B2; DT 23-MAR-2010, integrated into UniProtKB/TrEMBL. DT 23-MAR-2010, sequence version 1. DT 27-MAR-2024, entry version 81. DE RecName: Full=L-fucose isomerase {ECO:0000256|HAMAP-Rule:MF_01254}; DE Short=FucIase {ECO:0000256|HAMAP-Rule:MF_01254}; DE EC=5.3.1.25 {ECO:0000256|HAMAP-Rule:MF_01254}; DE AltName: Full=6-deoxy-L-galactose isomerase {ECO:0000256|HAMAP-Rule:MF_01254}; GN Name=fucI {ECO:0000256|HAMAP-Rule:MF_01254}; GN OrderedLocusNames=GYMC10_3924 {ECO:0000313|EMBL:ACX66153.1}; OS Geobacillus sp. (strain Y412MC10). OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus. OX NCBI_TaxID=481743 {ECO:0000313|EMBL:ACX66153.1, ECO:0000313|Proteomes:UP000002381}; RN [1] {ECO:0000313|Proteomes:UP000002381} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Y412MC10 {ECO:0000313|Proteomes:UP000002381}; RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., RA Brumm P., Mead D.; RT "Complete sequence of Geobacillus sp. Y412MC10."; RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACX66153.1, ECO:0000313|Proteomes:UP000002381} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Y412MC10 {ECO:0000313|EMBL:ACX66153.1, RC ECO:0000313|Proteomes:UP000002381}; RX PubMed=23408395; DOI=10.4056/sigs.2605792; RA Mead D.A., Lucas S., Copeland A., Lapidus A., Cheng J.F., Bruce D.C., RA Goodwin L.A., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C.S., RA Tapia R., Land M., Hauser L.J., Chang Y.J., Kyrpides N.C., Ivanova N.N., RA Ovchinnikova G., Woyke T., Brumm C., Hochstein R., Schoenfeld T., Brumm P.; RT "Complete Genome Sequence of Paenibacillus strain Y4.12MC10, a Novel RT Paenibacillus lautus strain Isolated from Obsidian Hot Spring in RT Yellowstone National Park."; RL Stand. Genomic Sci. 6:381-400(2012). CC -!- FUNCTION: Converts the aldose L-fucose into the corresponding ketose L- CC fuculose. {ECO:0000256|HAMAP-Rule:MF_01254}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-fucose = L-fuculose; Xref=Rhea:RHEA:17233, ChEBI:CHEBI:2181, CC ChEBI:CHEBI:17617; EC=5.3.1.25; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01254}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01254}; CC -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-lactaldehyde CC and glycerone phosphate from L-fucose: step 1/3. {ECO:0000256|HAMAP- CC Rule:MF_01254}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01254}. CC -!- SIMILARITY: Belongs to the L-fucose isomerase family. CC {ECO:0000256|HAMAP-Rule:MF_01254}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001793; ACX66153.1; -; Genomic_DNA. DR RefSeq; WP_009592101.1; NZ_VEAV01000002.1. DR AlphaFoldDB; D3E5B2; -. DR STRING; 481743.GYMC10_3924; -. DR KEGG; gym:GYMC10_3924; -. DR HOGENOM; CLU_033326_1_0_9; -. DR UniPathway; UPA00563; UER00624. DR Proteomes; UP000002381; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0008736; F:L-fucose isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0042355; P:L-fucose catabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.50.1070; -; 1. DR Gene3D; 3.20.14.10; L-fucose/L-arabinose isomerase, C-terminal; 1. DR HAMAP; MF_01254; Fucose_iso; 1. DR InterPro; IPR004216; Fuc/Ara_isomerase_C. DR InterPro; IPR038393; Fuc_iso_dom3_sf. DR InterPro; IPR015888; Fuc_isomerase_C. DR InterPro; IPR038391; Fucose_iso_dom1_sf. DR InterPro; IPR012888; Fucose_iso_N1. DR InterPro; IPR005763; Fucose_isomerase. DR InterPro; IPR038392; Fucose_isomerase_dom2_sf. DR InterPro; IPR009015; Fucose_isomerase_N/cen_sf. DR InterPro; IPR012889; Fucose_isomerase_N2. DR NCBIfam; TIGR01089; fucI; 1. DR PANTHER; PTHR37840; L-FUCOSE ISOMERASE; 1. DR PANTHER; PTHR37840:SF1; L-FUCOSE ISOMERASE; 1. DR Pfam; PF02952; Fucose_iso_C; 1. DR Pfam; PF07881; Fucose_iso_N1; 1. DR Pfam; PF07882; Fucose_iso_N2; 1. DR SUPFAM; SSF50443; FucI/AraA C-terminal domain-like; 1. DR SUPFAM; SSF53743; FucI/AraA N-terminal and middle domains; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP- KW Rule:MF_01254}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01254}; KW Fucose metabolism {ECO:0000256|ARBA:ARBA00023253, ECO:0000256|HAMAP- KW Rule:MF_01254}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_01254}; KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01254}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_01254}. FT DOMAIN 14..181 FT /note="L-fucose isomerase N-terminal-1" FT /evidence="ECO:0000259|Pfam:PF07881" FT DOMAIN 182..361 FT /note="L-fucose isomerase N-terminal-2" FT /evidence="ECO:0000259|Pfam:PF07882" FT DOMAIN 397..560 FT /note="L-fucose isomerase C-terminal" FT /evidence="ECO:0000259|Pfam:PF02952" FT ACT_SITE 344 FT /note="Proton acceptor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01254" FT ACT_SITE 368 FT /note="Proton acceptor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01254" FT BINDING 344 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01254" FT BINDING 368 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01254" FT BINDING 534 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01254" SQ SEQUENCE 597 AA; 66324 MW; 153F52302413B30B CRC64; MTIENDYRWR DGFPKIGIRP TIDGRRRGVR ESLEEQTMNL AKAVAEMLTK ELKYPNGEPV ECVIADTCIG GVAEATAAAK KFKNAEVGLT ITVTPCWCYG TETMDADPSR PKAVWGFNGT GRPGAVYLAA VLSAHAQKGL PAFGIYGEDV QDEGDTRIPD DVQEKLLRFA RSGLAAAYMR GQSYLSMGSV SMGIAGSIVD DSFFQEYLGM RNEYVDMSEF TRRLEEGIYD PEEYEKALAW VKENCTEGPD NNPDHLQNSR ERKDLEWETV VKMTLITRDL MIGNPRLKEL GFEEEAQGHS AIASGFQGQR QWTDHSPNGD FLETILNSSF DWNGRRSPYI VATENDSLNG VGMLFGYLLT NTAQIFADVR TYWSPASVER VTGYKLEGKA ENGILHLINS GSAALDGTGE QELDGKPAMK PFWDITDEEV DRTLKATQWR PANLEYFRGG GYSTDYLTRG GMPMTMFRLN LVKGLGPVLQ IAEGYSVDLP SEVHDTLDKR TDPTWPTTWF VPNLTGEGAF SSVYEVMNQW GANHGVISYG HIGADLITLA SVLRIPVNMH NVPANEVFRP RAWGMFGTSD PESADFRACQ NFGPLYK //