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Protein

L-fucose isomerase

Gene

fucI

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mn2+SAAS annotation
  • Mn2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei344 – 3441Proton acceptorUniRule annotation
Metal bindingi344 – 3441ManganeseUniRule annotation
Active sitei368 – 3681Proton acceptorUniRule annotation
Metal bindingi368 – 3681ManganeseUniRule annotation
Metal bindingi534 – 5341ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP481743:GH8K-3971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.25UniRule annotationSAAS annotation)
Short name:
FucIaseUniRule annotation
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:GYMC10_3924Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002381: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3E5B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249674.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

D3E5B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIENDYRWR DGFPKIGIRP TIDGRRRGVR ESLEEQTMNL AKAVAEMLTK
60 70 80 90 100
ELKYPNGEPV ECVIADTCIG GVAEATAAAK KFKNAEVGLT ITVTPCWCYG
110 120 130 140 150
TETMDADPSR PKAVWGFNGT GRPGAVYLAA VLSAHAQKGL PAFGIYGEDV
160 170 180 190 200
QDEGDTRIPD DVQEKLLRFA RSGLAAAYMR GQSYLSMGSV SMGIAGSIVD
210 220 230 240 250
DSFFQEYLGM RNEYVDMSEF TRRLEEGIYD PEEYEKALAW VKENCTEGPD
260 270 280 290 300
NNPDHLQNSR ERKDLEWETV VKMTLITRDL MIGNPRLKEL GFEEEAQGHS
310 320 330 340 350
AIASGFQGQR QWTDHSPNGD FLETILNSSF DWNGRRSPYI VATENDSLNG
360 370 380 390 400
VGMLFGYLLT NTAQIFADVR TYWSPASVER VTGYKLEGKA ENGILHLINS
410 420 430 440 450
GSAALDGTGE QELDGKPAMK PFWDITDEEV DRTLKATQWR PANLEYFRGG
460 470 480 490 500
GYSTDYLTRG GMPMTMFRLN LVKGLGPVLQ IAEGYSVDLP SEVHDTLDKR
510 520 530 540 550
TDPTWPTTWF VPNLTGEGAF SSVYEVMNQW GANHGVISYG HIGADLITLA
560 570 580 590
SVLRIPVNMH NVPANEVFRP RAWGMFGTSD PESADFRACQ NFGPLYK
Length:597
Mass (Da):66,324
Last modified:March 23, 2010 - v1
Checksum:i153F52302413B30B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX66153.1.
RefSeqiYP_003243960.1. NC_013406.1.

Genome annotation databases

EnsemblBacteriaiACX66153; ACX66153; GYMC10_3924.
GeneIDi8518108.
KEGGigym:GYMC10_3924.
PATRICi32156367. VBIGeoSp56627_3895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA. Translation: ACX66153.1.
RefSeqiYP_003243960.1. NC_013406.1.

3D structure databases

ProteinModelPortaliD3E5B2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX66153; ACX66153; GYMC10_3924.
GeneIDi8518108.
KEGGigym:GYMC10_3924.
PATRICi32156367. VBIGeoSp56627_3895.

Phylogenomic databases

HOGENOMiHOG000249674.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.

Enzyme and pathway databases

BioCyciPSP481743:GH8K-3971-MONOMER.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Geobacillus sp. Y412MC10."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Brumm P., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC10Imported.

Entry informationi

Entry nameiD3E5B2_GEOS4
AccessioniPrimary (citable) accession number: D3E5B2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: January 7, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.