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Protein

L-fucose isomerase

Gene

fucI

Organism
Geobacillus sp. (strain Y412MC10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotationSAAS annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationSAAS annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI), L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei344Proton acceptorUniRule annotation1
Metal bindingi344ManganeseUniRule annotation1
Active sitei368Proton acceptorUniRule annotation1
Metal bindingi368ManganeseUniRule annotation1
Metal bindingi534ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processCarbohydrate metabolism, Fucose metabolismUniRule annotationSAAS annotation
LigandManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.25UniRule annotationSAAS annotation)
Short name:
FucIaseUniRule annotation
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:GYMC10_3924Imported
OrganismiGeobacillus sp. (strain Y412MC10)Imported
Taxonomic identifieri481743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002381 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi481743.GYMC10_3924

Structurei

3D structure databases

ProteinModelPortaliD3E5B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 181Fucose_iso_N1InterPro annotationAdd BLAST168
Domaini182 – 361Fucose_iso_N2InterPro annotationAdd BLAST180
Domaini397 – 560Fucose_iso_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EHF Bacteria
COG2407 LUCA
HOGENOMiHOG000249674
KOiK01818
OMAiHAQKGLP
OrthoDBiPOG091H0GT3

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

D3E5B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIENDYRWR DGFPKIGIRP TIDGRRRGVR ESLEEQTMNL AKAVAEMLTK
60 70 80 90 100
ELKYPNGEPV ECVIADTCIG GVAEATAAAK KFKNAEVGLT ITVTPCWCYG
110 120 130 140 150
TETMDADPSR PKAVWGFNGT GRPGAVYLAA VLSAHAQKGL PAFGIYGEDV
160 170 180 190 200
QDEGDTRIPD DVQEKLLRFA RSGLAAAYMR GQSYLSMGSV SMGIAGSIVD
210 220 230 240 250
DSFFQEYLGM RNEYVDMSEF TRRLEEGIYD PEEYEKALAW VKENCTEGPD
260 270 280 290 300
NNPDHLQNSR ERKDLEWETV VKMTLITRDL MIGNPRLKEL GFEEEAQGHS
310 320 330 340 350
AIASGFQGQR QWTDHSPNGD FLETILNSSF DWNGRRSPYI VATENDSLNG
360 370 380 390 400
VGMLFGYLLT NTAQIFADVR TYWSPASVER VTGYKLEGKA ENGILHLINS
410 420 430 440 450
GSAALDGTGE QELDGKPAMK PFWDITDEEV DRTLKATQWR PANLEYFRGG
460 470 480 490 500
GYSTDYLTRG GMPMTMFRLN LVKGLGPVLQ IAEGYSVDLP SEVHDTLDKR
510 520 530 540 550
TDPTWPTTWF VPNLTGEGAF SSVYEVMNQW GANHGVISYG HIGADLITLA
560 570 580 590
SVLRIPVNMH NVPANEVFRP RAWGMFGTSD PESADFRACQ NFGPLYK
Length:597
Mass (Da):66,324
Last modified:March 23, 2010 - v1
Checksum:i153F52302413B30B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001793 Genomic DNA Translation: ACX66153.1
RefSeqiWP_009592101.1, NC_013406.1

Genome annotation databases

EnsemblBacteriaiACX66153; ACX66153; GYMC10_3924
KEGGigym:GYMC10_3924

Similar proteinsi

Entry informationi

Entry nameiD3E5B2_GEOS4
AccessioniPrimary (citable) accession number: D3E5B2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health