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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1) (Methanobacterium ruminantium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRUM634498:GHDG-988-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:mru_0953
OrganismiMethanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1) (Methanobacterium ruminantium)
Taxonomic identifieri634498 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000008680 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2342342-phospho-L-lactate guanylyltransferasePRO_0000398735Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi634498.mru_0953.

Structurei

3D structure databases

ProteinModelPortaliD3E2P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiRAVIPYK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

D3E2P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKIYAIIPV NQFANAKTRL SPFLTPEERR DLLKAMLKDI TDTLKPIVDK
60 70 80 90 100
VVIISRDEEV LAYAEELELT TIVEEEYKKS KAVNSSDDNP LNKALKQAMK
110 120 130 140 150
WSRKKTRKVI ILPSDIPLIG KTNVKLLIDQ AKNFDFIIVP SKGGGTNTLI
160 170 180 190 200
IKPLAIDMKF EGFSFNKHIE EAKRKKLVPI VHDSFYMALD VNTTEDLGEI
210 220 230
MLHGNGTETK KYLESLGIKV ESSHDHERLK VTRD
Length:234
Mass (Da):26,592
Last modified:March 23, 2010 - v1
Checksum:i46EFA283C6040880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001719 Genomic DNA. Translation: ADC46804.1.
RefSeqiWP_012955755.1. NC_013790.1.

Genome annotation databases

EnsemblBacteriaiADC46804; ADC46804; mru_0953.
GeneIDi8770605.
KEGGimru:mru_0953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001719 Genomic DNA. Translation: ADC46804.1.
RefSeqiWP_012955755.1. NC_013790.1.

3D structure databases

ProteinModelPortaliD3E2P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634498.mru_0953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC46804; ADC46804; mru_0953.
GeneIDi8770605.
KEGGimru:mru_0953.

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiRAVIPYK.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciMRUM634498:GHDG-988-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_METRM
AccessioniPrimary (citable) accession number: D3E2P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 23, 2010
Last modified: November 11, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.