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D3E0Q0 (D3E0Q0_METRM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2481N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2461ATP By similarity HAMAP-Rule MF_00407
Binding site2531ATP By similarity HAMAP-Rule MF_00407
Binding site2681ATP By similarity HAMAP-Rule MF_00407
Binding site2981ATP By similarity HAMAP-Rule MF_00407
Binding site4141ATP By similarity HAMAP-Rule MF_00407
Binding site4201ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D3E0Q0 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: 5C33843B98B80B05

FASTA55061,113
        10         20         30         40         50         60 
MKYEELVNVY EALGATTKRL EKTEILADFL KTVELEDLQK ITLMALGRVF PPWSEEEQGI 

        70         80         90        100        110        120 
GDKLVMKAVG DAVGVSVAVV EDAIRDEGDI GAAAEKLYGK KTQMTFFSQP LTVNFVYNQL 

       130        140        150        160        170        180 
RKLAKITGNR STAKKISNIL ELLSSASALE AKYICRTILE ELRIGVGEGI IRDAISQAFG 

       190        200        210        220        230        240 
VDKALAERAH MLTNDLGLVA KVAKEEGEDG LKKLSLIPGR PVKPMLAQLS EGIEISINEM 

       250        260        270        280        290        300 
GCALCETKYD GIRMQVHKKD DEITIFTRRL ENVTMALPEA VDLIREAFPD EDFIAEGEII 

       310        320        330        340        350        360 
AIRDGKPTTF QNILQRVRRK HNIEEAMEKV PIKIYLYDLL YFKEPTIDEP IIKRREILES 

       370        380        390        400        410        420 
VVDCSNPNLA LSSLVKVGPD NIDDAVDLFN KSIEGGHEGI MIKDCDEPYI PGIRGKKMLK 

       430        440        450        460        470        480 
LKAEPETLDA VVIGGVKGIG KRGDFIGSYV IALRDENDQL QPIAHVGTGL SDDDLANLTE 

       490        500        510        520        530        540 
KMEALKITEK GTRITVHPKI VFEIAYSEIV KSPEYSAGYS LRFPVVKRIR DDKGVDDIDT 

       550 
IERLESMFKG

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References

[1]"The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions."
Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J., Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C., Janssen P.H., Dey D., Attwood G.T.
PLoS ONE 5:E8926-E8926(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35063 / DSM 1093 / JCM 13430 / M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001719 Genomic DNA. Translation: ADC46296.1.
RefSeqYP_003423188.1. NC_013790.1.

3D structure databases

ProteinModelPortalD3E0Q0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC46296; ADC46296; mru_0445.
GeneID8770085.
KEGGmru:mru_0445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.
OMAARVQVHK.

Enzyme and pathway databases

BioCycMRUM634498:GHDG-468-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3E0Q0_METRM
AccessionPrimary (citable) accession number: D3E0Q0
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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