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D3DYU7 (HPRT_METRM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine/guanine phosphoribosyltransferase

Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:mru_0165
OrganismMethanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / M1) (Methanobacterium ruminantium) [Complete proteome] [HAMAP]
Taxonomic identifier634498 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_01467

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. HAMAP-Rule MF_01467

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01467

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01467.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Hypoxanthine/guanine phosphoribosyltransferase HAMAP-Rule MF_01467
PRO_0000415465

Sequences

Sequence LengthMass (Da)Tools
D3DYU7 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: CA07E7E9D84AA1C9

FASTA18820,346
        10         20         30         40         50         60 
MLENLVESLR NAPVVKKGDY DYFVHGISDG IPALNPCVLK EISEVLAERI DLDKVDKIVG 

        70         80         90        100        110        120 
VEAMGIHIAT ALSLETGLPL LVIRKREYGL EGEHEILKHT GYATSKLYIN DLNEGDNIVL 

       130        140        150        160        170        180 
VDDVVSTGGT LSVVINELKA IGVNILDTFV VVEKGEGKKI VEDKTGENIV TLVKLDVVDG 


KVVADSLI 

« Hide

References

[1]"The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions."
Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J., Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C., Janssen P.H., Dey D., Attwood G.T.
PLoS ONE 5:E8926-E8926(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35063 / DSM 1093 / JCM 13430 / M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001719 Genomic DNA. Translation: ADC46017.1.
RefSeqYP_003422909.1. NC_013790.1.

3D structure databases

ProteinModelPortalD3DYU7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC46017; ADC46017; mru_0165.
GeneID8769784.
KEGGmru:mru_0165.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228520.
KOK00759.
OMAIATDIPY.

Enzyme and pathway databases

BioCycMRUM634498:GHDG-167-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01467. Hypx_phosphoribosyltr.
InterProIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_METRM
AccessionPrimary (citable) accession number: D3DYU7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 23, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways