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Protein
Submitted name:

Leucine zipper-EF-hand containing transmembrane protein 1, isoform CRA_a

Gene

LETM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi496 – 507PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine zipper-EF-hand containing transmembrane protein 1, isoform CRA_aImported
Gene namesi
Name:LETM1Imported
ORF Names:hCG_1818300Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 49HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, MitochondrionPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000168924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 357Letm1 RBD (ribosome-binding)InterPro annotationAdd BLAST286
Domaini483 – 518EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 416Sequence analysisAdd BLAST59
Coiled coili531 – 559Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
PfamiView protein in Pfam
PF07766. LETM1. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS51758. LETM1_RBD. 1 hit.

Sequencei

Sequence statusi: Complete.

D3DVQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWRILNGHS LTRRERRQFL RICADLFRLV PFLVFVVVPF MEFLLPVAVK
60 70 80 90 100
LFPNMLPSTF ETQSLKEERL KKELRVKLEL AKFLQDTIEE MALKNKAAKG
110 120 130 140 150
SATKDFSVFF QKIRETGERP SNEEIMRFSK LFEDELTLDN LTRPQLVALC
160 170 180 190 200
KLLELQSIGT NNFLRFQLTM RLRSIKADDK LIAEEGVDSL NVKELQAACR
210 220 230 240 250
ARGMRALGVT EDRLRGQLKQ WLDLHLHQEI PTSLLILSRA MYLPDTLSPA
260 270 280 290 300
DQLKSTLQTL PEIVAKEAQV KVAEVEGEQV DNKAKLEATL QEEAAIQQEH
310 320 330 340 350
REKELQKRSE VAKDFEPERV VAAPQRPGTE PQPEMPDTVL QSETLKDTAP
360 370 380 390 400
VLEGLKEEEI TKEEIDILSD ACSKLQEQKK SLTKEKEELE LLKEDVQDYS
410 420 430 440 450
EDLQEIKKEL SKTGEEKYVE ESKASKRLTK RVQQMIGQID GLISQLEMDQ
460 470 480 490 500
QAGKLAPANG MPTGENVISV AELINAMKQV KHIPESKLTS LAAALDENKD
510 520 530 540 550
GKVNIDDLVK VIELVDKEDV HISTSQVAEI VATLEKEEKV EEKEKAKEKA

EKEVAEVKS
Length:559
Mass (Da):63,541
Last modified:March 23, 2010 - v1
Checksum:iF591ABA877FD3D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471131 Genomic DNA. Translation: EAW82560.1.
CH471131 Genomic DNA. Translation: EAW82561.1.
RefSeqiXP_016863676.1. XM_017008187.1.
UniGeneiHs.120165.

Genome annotation databases

GeneIDi3954.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3DVQ1_HUMAN
AccessioniPrimary (citable) accession number: D3DVQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 5, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.