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Protein
Submitted name:

Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_a

Gene

ARHGEF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_aImported
Gene namesi
Name:ARHGEF2Imported
ORF Names:hCG_1996334Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiD3DVA5.
PeptideAtlasiD3DVA5.
PRIDEiD3DVA5.

Expressioni

Gene expression databases

BgeeiENSG00000116584.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354837.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 131Phorbol-ester/DAG-typeInterPro annotationAdd BLAST48
Domaini279 – 476DH (DBL-homology)InterPro annotationAdd BLAST198
Domaini516 – 615PHInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili876 – 910Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IR0Y. Eukaryota.
ENOG410XT68. LUCA.
HOGENOMiHOG000236361.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DVA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKSVPVSG INCLLDRSDT DGNVSQSSAI DLRKRCSQLE GHSGTRVGSS
60 70 80 90 100
LRQTFSFLSG MTGKAKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA
110 120 130 140 150
CNKSITAKEA LICPTCNVTI HNRCKDTLAN CTKVKQKQQK AALLKNNTAL
160 170 180 190 200
QSVSLRSKTT IRERPSSAIY PSDSFRQSLL GSRRGRSSLS LAKSVSTTNI
210 220 230 240 250
AGHFNDESPL GLRRILSQST DSLNMRNRTL SVESLIDEEV IYSELMSDFE
260 270 280 290 300
MDEKDFAADS WSLAVDSSFL QQHKKEVMKQ QDVIYELIQT ELHHVRTLKI
310 320 330 340 350
MTRLFRTGML EELHLEPGVV QGLFPCVDEL SDIHTRFLSQ LLERRRQALC
360 370 380 390 400
PGSTRNFVIH RLGDLLISQF SGPSAEQMCK TYSEFCSRHS KALKLYKELY
410 420 430 440 450
ARDKRFQQFI RKVTRPAVLK RHGVQECILL VTQRITKYPL LISRILQHSH
460 470 480 490 500
GIEEERQDLT TALGLVKELL SNVDEGIYQL EKGARLQEIY NRMDPRAQTP
510 520 530 540 550
VPGKGPFGRE ELLRRKLIHD GCLLWKTATG RFKDVLVLLM TDVLVFLQEK
560 570 580 590 600
DQKYIFPTLD KPSVVSLQNL IVRDIANQEK GMFLISAAPP EMYEVHTASR
610 620 630 640 650
DDRSTWIRVI QQSVRTCPSR EDFPLIETED EAYLRRIKME LQQKDRALVE
660 670 680 690 700
LLREKVGLFA EMTHFQAEED GGSGMALPTL PRGLFRSESL ESPRGERLLQ
710 720 730 740 750
DAIREVEGLK DLLVGPGVEL LLTPREPALP LEPDSGGNTS PGVTANGEAR
760 770 780 790 800
TFNGSIELCR ADSDSSQRDR NGNQLRSPQE EALQRLVNLY GLLHGLQAAV
810 820 830 840 850
AQQDTLMEAR FPEGPERREK LCRANSRDGE AGRAGAAPVA PEKQATELAL
860 870 880 890 900
LQRQHALLQE ELRRCRRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEA
910 920 930 940 950
RRQLAALGQT EPLPAEAPWA RRPVDPRRRS LPAGDALYLS FNPPQPSRGT
960 970 980 990 1000
DRLDLPVTTR SVHRNFEDRE RQELGSPEER LQDSSDPDTG SEEEGSSRLS
1010 1020 1030
PPHSPRDFTR MQDIPEETES RDGEAVASES
Length:1,030
Mass (Da):116,000
Last modified:March 23, 2010 - v1
Checksum:i1973CF7ADEE91D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471121 Genomic DNA. Translation: EAW53012.1.
CH471121 Genomic DNA. Translation: EAW53017.1.
UniGeneiHs.743352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471121 Genomic DNA. Translation: EAW53012.1.
CH471121 Genomic DNA. Translation: EAW53017.1.
UniGeneiHs.743352.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354837.

Proteomic databases

MaxQBiD3DVA5.
PeptideAtlasiD3DVA5.
PRIDEiD3DVA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

CTDi9181.

Phylogenomic databases

eggNOGiENOG410IR0Y. Eukaryota.
ENOG410XT68. LUCA.
HOGENOMiHOG000236361.

Miscellaneous databases

ChiTaRSiARHGEF2. human.
GenomeRNAii9181.

Gene expression databases

BgeeiENSG00000116584.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3DVA5_HUMAN
AccessioniPrimary (citable) accession number: D3DVA5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.